Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jayajit Das"'
BioNetGMMFit: estimating parameters of a BioNetGen model from time-stamped snapshots of single cells
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Mechanistic models are commonly employed to describe signaling and gene regulatory kinetics in single cells and cell populations. Recent advances in single-cell technologies have produced multidimensional datasets where snapshots of copy num
Externí odkaz:
https://doaj.org/article/b035828b037b46c8b533329d18eb43e5
Autor:
Zihai Li, Yuanquan Yang, Amir Mortazavi, Mingjia Li, Daniel Spakowicz, Komal Das, Jayajit Das, Giuseppe Giuliani, Anil Parwani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/18668a75766a496696a1fcb19c01e7c6
Autor:
Yi Wang, David Carbone, Zihai Li, Yiping Yang, Kai He, Anqi Li, Qin Ma, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Brian P Riesenberg, Maria Velegraki, Giuseppe D Giuliani, Komal Das, Tamio Okimoto, Hyunwoo Kwon, Karthik B Chakravarthy, Chelsea Bolyard, Jayajit Das, Daniel T Gewirth
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most patients with cancer fail to respond clinically. One potential reason is the accumulation of immunosuppressive transforming growth factor β (TGFβ) in
Externí odkaz:
https://doaj.org/article/03ec713396c14deca3b91ccdcc04d832
Autor:
Rajdeep Kaur Grewal, Jayajit Das
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010114 (2022)
Natural Killer (NK) cells provide key resistance against viral infections and tumors. A diverse set of activating and inhibitory NK cell receptors (NKRs) interact with cognate ligands presented by target host cells, where integration of dueling signa
Externí odkaz:
https://doaj.org/article/ecdbc2c4f850458ba6d1ad0848547cf3
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009931 (2022)
Cytometry experiments yield high-dimensional point cloud data that is difficult to interpret manually. Boolean gating techniques coupled with comparisons of relative abundances of cellular subsets is the current standard for cytometry data analysis.
Externí odkaz:
https://doaj.org/article/a8882e979b7d4715acc9a9a6eec8a863
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/ff114394d8c140b78f4b5ba8992a9572
Autor:
Jonathan R. Brown, Joseph Jurcisek, Vinal Lakhani, Ali Snedden, William C. Ray, Elaine M. Mokrzan, Lauren O. Bakaletz, Jayajit Das
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Biofilms formed by nontypeable Haemophilus influenzae (NTHI) bacteria play an important role in multiple respiratory tract diseases. Visual inspection of the morphology of biofilms formed during chronic infections shows distinct differences
Externí odkaz:
https://doaj.org/article/febc5233e12b4408b9af5d6b26c90fba
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural Killer (NK) cell activation requires integration of inhibitory and activating signaling. Inhibitory signals are determined by members of the killer cell immunoglobulin-like receptor (KIR) family, which have major histocompatibility complex (M
Externí odkaz:
https://doaj.org/article/9fd8b8a0ae2c4ec9a81f19d63122c0c0
Publikováno v:
Royal Society Open Science, Vol 5, Iss 11 (2018)
Otitis media (OM) is a common polymicrobial infection of the middle ear in children under the age of 15 years. A widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of OM is to study changes in co-infectio
Externí odkaz:
https://doaj.org/article/48eeb41e3bfc481bae6f9068c1bf39e1
Autor:
Jayajit Das, Elaine Mokrzan, Vinal Lakhani, Lucia Rosas, Joseph A. Jurcisek, William C. Ray, Lauren O. Bakaletz
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Biofilms formed in the middle ear by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and refractive nature of otitis media (OM). However, mechanisms that underlie the emergence of specific NTHI biofilm st
Externí odkaz:
https://doaj.org/article/269d60c2a31d4aa6abd25f344b89f542