Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

Autor: Tsehai A.J. Grell, Mark Mason, Aaron A. Thompson, Jose Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth Steele, Rodrigo F. Ortiz-Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu

Publikováno v: Heliyon, Vol 8, Iss 12, Pp e12392- (2022)

Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-charac

Externí odkaz: https://doaj.org/article/0f71dae03abd4550a60deb71f7723386

Structures of human Malic Enzyme 3

Autor: Tsehai A.J. Grell, Mark Mason, Aaron A. Thompson, Jose Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth Steele, Rodrigo F. Ortiz-Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu

SummaryMalic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50095029d8863dba9d06b7ecf173a2ab
https://doi.org/10.1101/2022.08.25.505315

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

Autor: Jeroen van Ameijde, Trevin Holland, Hanna Inganäs, Ian A. Wilson, Gabriel Pascual, Hanneke Verveen, Roosmarijn Janson, Donata de Marco, Jeroen J.M. Hoozemans, Esther J. M. Stoop, Stefan Steinbacher, Renske Taggenbrock, Berdien Siregar, Rosa Crespo, Jay Wadia, Wouter Koudstaal, Margot van Winsen, Koen Dockx, Adrian Constantin Apetri, Jaap Goudsmit, Wenli Yu, David Zuijdgeest, Marianne Borgers, Jarek Juraszek, Heng Zhang, Elissa Keogh, Kristof Van Kolen, Kimberley Ummenthum, Martin H. Koldijk, Marc Mercken, Xueyong Zhu, Els C. M. Brinkman-Van der Linden, Michael Mrosek

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Apetri, A, Crespo, R, Juraszek, J, Pascual, G, Janson, R, Zhu, X, Zhang, H, Keogh, E, Holland, T, Wadia, J, Verveen, H, Siregar, B, Mrosek, M, Taggenbrock, R, Ameijde, J, Inganäs, H, van Winsen, M, Koldijk, M H, Zuijdgeest, D, Borgers, M, Dockx, K, Stoop, E J M, Yu, W, Brinkman-van der Linden, E C, Ummenthum, K, van Kolen, K, Mercken, M, Steinbacher, S, de Marco, D, Hoozemans, J J, Wilson, I A, Koudstaal, W & Goudsmit, J 2018, ' A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities ', Acta Neuropathologica Communinications, vol. 6, no. 1, 43, pp. 43 . https://doi.org/10.1186/s40478-018-0543-z, https://doi.org/10.1186/s40478-018-0543-z
Acta Neuropathologica Communinications, 6(1):43. BioMed Central

Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG + memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cc3ef318c798400926689fc83aaa11
http://link.springer.com/article/10.1186/s40478-018-0543-z

Evidence for breathing of a class I fusion protein at the cell surface

Autor: Jennifer Lum, Angelique van 't Wout, Jerome Custer, Polina Furmanova, Anthony Williamson, Jason S. McLellan, Gabriel Pasqual, Jay Wadia, Johannes P. M. Langedijk, Morgan S.A. Gilman

Publikováno v: Acta Crystallographica Section A Foundations and Advances. 74:a312-a312

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f0de50d45e700ddc2170eecd97232c3
https://doi.org/10.1107/s0108767318096885