Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jay W. Wright"'
Publikováno v:
Human Reproduction. 26:1408-1421
Background Epithelial ovarian cancer (EOC) risk correlates strongly with the number of ovulations that a woman experiences. The primary source of EOC in women is the ovarian surface epithelium (OSE). Mechanistic studies on the etiology of OSE transfo
Autor:
Michaele Peters, Tim Wintermantel, Micaela Sims, Alistair Bahar, Melissa Thorne, Bernhard Lindenthal, Jay W. Wright, Jon D. Hennebold, Richard L. Stouffer, Fuhua Xu, Jörg Müller, Gabriele Leder
Publikováno v:
MHR: Basic science of reproductive medicine. 17:152-165
Experiments were designed to evaluate changes in the transcriptome (mRNA levels) in the ovulatory, luteinizing follicle of rhesus monkeys, using a controlled ovulation model that permits analysis of the naturally selected, dominant follicle at specif
Autor:
Leigh Jurevic, Richard L. Stouffer, Maralee S. Lawson, Theodore R. Hobbs, Jay W. Wright, Tanja Pejovic
Publikováno v:
Biology of Reproduction. 82:599-605
The ovarian surface epithelium (OSE) has a prominent role in ovarian cancer in women, but no studies have been conducted to evaluate its role in normal ovarian function. Data from other species suggest the OSE is needed for ovulation. We have tested
Publikováno v:
Human Reproduction. 23:129-138
BACKGROUND Epithelial ovarian cancer (EOC) is the primary ovarian malignancy affecting women. Proposed etiologies of EOC resist direct testing due to the absence of a suitable animal model, as EOC affects only primates, not other mammals. The role of
Autor:
Philip F. Copenhaver, Jay W. Wright
Publikováno v:
Developmental Biology. 234(1):24-41
During the formation of the insect peripheral nervous system (PNS), the cell adhesion receptor fasciclin II has been shown to play a prominent role in axonal fasciculation and synapse formation during motor neuron outgrowth. In the moth Manduca , fas
Publikováno v:
Journal of Cardiac Failure. 1:155-160
Based on in vitro data suggesting an interaction between methylxanthines and doxorubicin in regulating Ca2+ across muscle sarcoplasmic reticulum, this study was designed to test the hypothesis that a commonly used methylxanthine, caffeine, might infl
Autor:
Paulette Mhawech-Fauceglia, Weiya Z. Wysham, Laura E. Hays, Hong Li, Jay W. Wright, Maureen E. Hoatlin, Tanja Pejovic, Nupur T. Pande, Tijana Skrepnik, Suzanna Syriac
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30042 (2012)
PLoS ONE
PLoS ONE
BackgroundThe consequences of defective homologous recombination (HR) are not understood in sporadic ovarian cancer, nor have the potential role of HR proteins other than BRCA1 and BRCA2 been clearly defined. However, it is clear that defects in HR a
Autor:
Jay W. Wright, Richard L. Stouffer, Tanja Pejovic, Theodore R. Hobbs, Cecily V. Bishop, Leigh Jurevic
Publikováno v:
Human reproduction (Oxford, England). 26(6)
background: The fifth leading cause of cancer deaths among women is ovarian cancer (OC), which originates primarily in the ovarian surface epithelium (OSE) that surrounds the ovary. Permanent removal of the OSE could provide a novel strategy to subst
Publikováno v:
Journal of Biological Chemistry. 268:18844-18849
This study reports the first demonstration of a marked reduction in alpha-crystallin chaperone activity in an experimental model of cataract, and the study implicates activation of the cysteine protease calpain II (EC 3.4.22.17) as the in vivo protea
Autor:
Jay W, Wright, Tanja, Pejovic, Maralee, Lawson, Leigh, Jurevic, Theodore, Hobbs, Richard L, Stouffer
Publikováno v:
Biology of reproduction. 82(3)
The ovarian surface epithelium (OSE) has a prominent role in ovarian cancer in women, but no studies have been conducted to evaluate its role in normal ovarian function. Data from other species suggest the OSE is needed for ovulation. We have tested