Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jay W. Schaub"'
Autor:
Katie T. Freeman, Jay W. Schaub, Stacey L. Wilber, Carrie Haskell-Luevano, Cody J. Lensing, Marvin L. Dirain, Srinivasa R. Tala, Viktor Flores, Mark D. Ericson, Erica M. Haslach, Branden A. Smeester, Robert C. Speth, Natalie Eick, Anamika Singh, Danielle N. Adank
Publikováno v:
Journal of Medicinal Chemistry. 61:3738-3744
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agoni
Autor:
Amy Andreasen, Glenn A. Walter, Kim R. Haskell, Lorraine M. Koerper, William J. Millard, Sally A. Litherland, Henry V. Baker, Francois Rouzaud, Marcus C. Moore, Carrie Haskell-Luevano, Jay W. Schaub, Zhimin Xiang
Publikováno v:
The FASEB Journal. 23:642-655
Exercise is a mechanism for maintenance of body weight in humans. Morbidly obese human patients have been shown to possess single nucleotide polymorphisms in the melanocortin-4 receptor (MC4R). MC4R knockout mice have been well characterized as a gen
Publikováno v:
Advances in experimental medicine and biology. 681
As the percentage of obese humans expands, new options for weight loss are being explored. Body weight homeostasis is the result of a balance between energy intake (food) and expenditure (activity). A shift in homeostasis into a negative balance resu
Publikováno v:
Peptides. 31(12)
Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781441963536
As the percentage of obese humans expands, new options for weight loss are being explored. Body weight homeostasis is the result of a balance between energy intake (food) and expenditure (activity). A shift in homeostasis into a negative balance resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d0afc78ff83574f8298cdca0075448
https://doi.org/10.1007/978-1-4419-6354-3_4
https://doi.org/10.1007/978-1-4419-6354-3_4
Publikováno v:
Bioorganicmedicinal chemistry. 17(3)
The melanocortin pathway has emerged during this past decade as an important target area for the discovery and development of therapeutic agents related to obesity and type 2 diabetes. This peptide-G-protein coupled receptor (GPCR) pathway has evolve