Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jay W. Constantine"'
Autor:
Frank E. Ewing, Jon Bordner, Wesley Lebel, Heidi A. Woody, R. Michael Snider, Kelly P. Longo, Jay W. Constantine, John A. Lowe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:839-842
The synthesis and SAR of a series of 2-aryl-1-azabicyclo[2.2.2]octanes structurally related to the nonpeptide substance P antagonists CP-96,345 and CP-99,994 are described. The novel SAR observed at the 2-position in these derivatives represents a hy
Autor:
Wesley Lebel, Delvin R. Knight, Eric A. Wolfgang, Jay W. Constantine, Heidi A. Woody, Patricia A. Benoit
Publikováno v:
European Journal of Pharmacology. 252:275-282
CP-96,345, a non-peptide, selective tachykinin NK1 receptor blocker and its inactive enantiomer, CP-96,344, inhibit ligand binding of phenylalkylamine but not dihydropyridine Ca2+ channel antagonists. Whether these Ca2+ channel antagonist properties
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 342:722-724
Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9, and 6.0, respectively. [D-Pro2, D-Trp7, 9]-substance P, a competitive tachykinin antagonist, had pA2 values of
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 344
The effects of substance P, neurokinin A, neurokinin B, [Sar9, Met(O2)11]-substance P, [Nle10]-neurokinin A (4-10) and senktide (succinyl-[Asp6, MePhe8]-substance P (6-11)) on blood pressure and heart rate were studied in anesthetized dogs. Dose-depe
Publikováno v:
European Journal of Pharmacology. 85:325-329
Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenozybenzamine-resistant responses to clonidine were not affected by prazosin or by
Publikováno v:
American Heart Journal. 106:1216-1221
As part of an ongoing investigation into the cardiovascular properties of trimazosin, 99 male Sprague-Dawley rats were anesthetized and cannulas were placed in jugular veins for administration of drugs. The rats were injected with phenylephrine and t
Publikováno v:
European Journal of Pharmacology. 66:281-286
Prazosin inhibited contractions o isolated-electrically stimulated dog pulmonary artery preincubated with (−)-7- 3 H-norepinephrine, but had no effect on 3 H-overflow, whereas yohimbine enhanced both responses. In pithed dogs the cumulative doses o
Autor:
Kenneth J. Blackburn, Mary S. Ghaly, Laurie G. Pullman, Michael L. Hayden, David S. Salsburg, Jay W. Constantine, David Cambridge, Sharat Shevde, Colin R. Taylor, Adeoye Y. Olukotun, Peter F. Moore, Hugh M. McIhenny, James R.C. Baird, Craig Allan Paul Dance Saxton
Publikováno v:
American Heart Journal. 102:515-532
The animal and human pharmacology of several new drugs (prazosin, trimazosin, pirbuterol, and carbazeran) useful in the treatment of congestive heart failure (CHF) is delineated in relation to the pharmacology of other agents employed for CHF managem
Autor:
Jay W. Constantine, Hans-Jurgen Hess
Publikováno v:
Journal of Medicinal Chemistry. 7:602-606
Publikováno v:
The Journal of New Drugs. 4:249-257