Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jay T Evans"'
Autor:
Stephanie K. Lathrop, Jordan J. Clark, Karthik Siram, Robert Andreata-Santos, Jeremy Yong, Rebekah D. Tee, Clara J. Davison, Gagandeep Singh, David Burkhart, Florian Krammer, Jay T. Evans
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-12 (2024)
Abstract Many different platforms have been used to develop highly protective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans. However, protection has eroded over time due to the emergence of antigenically dive
Externí odkaz:
https://doaj.org/article/691de1013f4746969e948200a1fa7aec
Autor:
Viktoria Rungelrath, Mushtaq Ahmed, Linda Hicks, Shannon M. Miller, Kendal T. Ryter, Kyle Montgomery, George Ettenger, Alexander Riffey, Walid M. Abdelwahab, Shabaana Abdul Khader, Jay T. Evans
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the top infectious killers in the world. The only licensed vaccine against TB, Bacille Calmette-Guérin (BCG), provides variable protection against pulmonary TB, especi
Externí odkaz:
https://doaj.org/article/e64a5807aee049cf945f9fb7b0aaa82f
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003875 (2014)
Influenza disease is a global health issue that causes significant morbidity and mortality through seasonal epidemics. Currently, inactivated influenza virus vaccines given intramuscularly or live attenuated influenza virus vaccines administered intr
Externí odkaz:
https://doaj.org/article/3d5f6fdb3b4047659ce3c2f9a0f85daf
Autor:
Konner J. Jackson, Cassandra Buhl, Shannon M. Miller, Juhienah K. Khalaf, Janine Ward, Cherrokee Sands, Lois Walsh, Margaret Whitacre, David J. Burkhart, Hélène G. Bazin-Lee, Jay T. Evans
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAtopic diseases have been steadily increasing over the past decades and effective disease-modifying treatment options are urgently needed. These studies introduce a novel synthetic Toll-like receptor 4 (TLR4) agonist, INI-2004, with remar
Externí odkaz:
https://doaj.org/article/9b60a2eb358d47ecbea880c10933a65d
Autor:
Asia Marie S. Riel, Viktoria Rungelrath, Tamer A. Elwaie, Omer K. Rasheed, Linda Hicks, George Ettenger, Dai-Chi You, Mira Smith, Cassandra Buhl, Walid Abdelwahab, Shannon M. Miller, Alyson J. Smith, David Burkhart, Jay T. Evans, Kendal T. Ryter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10031 (2024)
The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, and therefore represents a promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pha
Externí odkaz:
https://doaj.org/article/2dcbd9569bd64307b41ca36f7193a98b
Autor:
Bethany Crouse, Shannon M. Miller, Peter Muelken, Linda Hicks, Jennifer R. Vigliaturo, Cheryl L. Marker, Alonso G. P. Guedes, Paul R. Pentel, Jay T. Evans, Mark G. LeSage, Marco Pravetoni
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Opioid use disorders (OUD) and overdose are public health threats worldwide. Widespread access to highly potent illicit synthetic opioids such as fentanyl is driving the recent rise in fatal overdoses. Vaccines containing fentanyl-based hapt
Externí odkaz:
https://doaj.org/article/84711b1689474c11879e5e0dec9e620c
Autor:
Shannon M. Miller, Bethany Crouse, Linda Hicks, Hardik Amin, Shelby Cole, Helene G. Bazin, David J. Burkhart, Marco Pravetoni, Jay T. Evans
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Opioid use disorders (OUD) and opioid-related fatal overdoses are a public health concern in the United States. Approximately 100,000 fatal opioid-related overdoses occurred annually from mid-2020 to the present, the majority of which involv
Externí odkaz:
https://doaj.org/article/1da1be1405e24b4a9876d785eb6244f4
Autor:
David J. Dowling, Soumik Barman, Alyson J. Smith, Francesco Borriello, Danielle Chaney, Spencer E. Brightman, Gandolina Melhem, Byron Brook, Manisha Menon, Dheeraj Soni, Simone Schüller, Karthik Siram, Etsuro Nanishi, Hélène G. Bazin, David J. Burkhart, Ofer Levy, Jay T. Evans
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and childhood, but in some cases the fu
Externí odkaz:
https://doaj.org/article/664c1c1f13a04a379a816fa55d3b47b1
Autor:
Valery C. Román-Cruz, Shannon M. Miller, Roman A. Schoener, Chase Lukasiewicz, Amelia K. Schmidt, Blair L. DeBuysscher, David Burkhart, Patrick R. Secor, Jay T. Evans
Publikováno v:
Vaccines, Vol 12, Iss 2, p 115 (2024)
Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, resulted in approximately 559,000 deaths globally in 2019. Pa has a multitude of host-immune evasion strategies that enhance Pa virulence. Most clinical isolates of Pa are infected by a phage ca
Externí odkaz:
https://doaj.org/article/9528f8ec464343d482cb4702bfdba912
Autor:
Walid M. Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G. Bazin, Howard B. Cottam, Tomoko Hayashi, Jay T. Evans, David J. Burkhart
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 107 (2024)
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery plat
Externí odkaz:
https://doaj.org/article/26544322b0c64072a9ae66274353b9af