Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jay Spampanato"'
Autor:
Yueqi Wang, Simone Chiola, Guang Yang, Chad Russell, Celeste J. Armstrong, Yuanyuan Wu, Jay Spampanato, Paisley Tarboton, H. M. Arif Ullah, Nicolas U. Edgar, Amelia N. Chang, David A. Harmin, Vittoria Dickinson Bocchi, Elena Vezzoli, Dario Besusso, Jun Cui, Elena Cattaneo, Jan Kubanek, Aleksandr Shcheglovitov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Our understanding of human brain development in health and disease is limited. The authors generated human brain organoids from stem cell-derived isolated single neural rosettes to study human cortico-striatal development and deficits caused by an au
Externí odkaz:
https://doaj.org/article/d1806db84e9849f5a38b0040f1ac1b0d
Autor:
Timothy B. C. Johnstone, Hilary S. McCarren, Jay Spampanato, F. Edward Dudek, John H. McDonough, Derk Hogenkamp, Kelvin W. Gee
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extr
Externí odkaz:
https://doaj.org/article/25d1ae99c446488ba9de5d89a56a1187
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e41029 (2012)
The dentate gyrus is a neurogenic zone where neurons continue to be born throughout life, mature and integrate into the local circuitry. In adults, this generation of new neurons is thought to contribute to learning and memory formation. As newborn n
Externí odkaz:
https://doaj.org/article/8c83ca49987b4a2388a89cc6d85aa342
Autor:
Jay Spampanato, Kyle Berger, Cecelia E. Jackson, John H. McDonough, Hilary S. McCarren, F. Edward Dudek, Bryan S. Barker, David T. Yeung
Publikováno v:
Neuroscience. 463:143-158
Benzodiazepines are the primary treatment option for organophosphate (OP)-induced status epilepticus (SE), but these antiseizure drugs (ASDs) lose efficacy as treatment is delayed. In the event of a mass civilian or military exposure, significant tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e9bf76b1e29464d43dcbd1c8607ea5
https://doi.org/10.1016/j.neuroscience.2021.03.029
https://doi.org/10.1016/j.neuroscience.2021.03.029
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:59-68
Organophosphate (OP) exposure induces status epilepticus (SE), a medical emergency with high morbidity and mortality. Current standard medical countermeasures lose efficacy with time so that treatment delays, in the range of tens of minutes, result i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e2915ba9f7513de36872c1e26b8bf9
https://doi.org/10.1124/jpet.120.000175
https://doi.org/10.1124/jpet.120.000175
Autor:
David T. Yeung, Jay Spampanato, Bryan S. Barker, Cecelia Jackson, F. Edward Dudek, John H. McDonough, Hilary S. McCarren, Melissa Smolik, Eden N. Hornung
Publikováno v:
Neuroscience
Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an excess of peripheral ailments, OP intoxication induces status epilepticus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a183ea9a758cd65879acd4ba3a50be5
https://doi.org/10.1016/j.neuroscience.2019.11.020
https://doi.org/10.1016/j.neuroscience.2019.11.020
Autor:
Bryan S, Barker, Jay, Spampanato, Hilary S, McCarren, Kyle, Berger, Cecelia E, Jackson, David T, Yeung, F Edward, Dudek, John H, McDonough
Publikováno v:
Neuroscience
Benzodiazepines are the primary treatment option for organophosphate (OP)-induced status epilepticus (SE), but these antiseizure drugs (ASDs) lose efficacy as treatment is delayed. In the event of a mass civilian or military exposure, significant tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::392ec4cba73e3e000586b148bdaa97c5
https://pubmed.ncbi.nlm.nih.gov/33836243
https://pubmed.ncbi.nlm.nih.gov/33836243
Autor:
John H. McDonough, Derk J. Hogenkamp, Hilary S. McCarren, Timothy B C Johnstone, Kelvin W. Gee, F. Edward Dudek, Jay Spampanato
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2a3410da40e39e8052d60d7c68080c
http://europepmc.org/articles/PMC6543275
http://europepmc.org/articles/PMC6543275
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4932214ba285884ef98d0bb6ad6debc3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.205.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.205.3
Publikováno v:
Epilepsia
Objective Exposure to organophosphates (OPs) and OP nerve agents (NAs) causes status epilepticus (SE) and irreversible brain damage. Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab91896a6d314d9cd148f348031ff3c
https://pubmed.ncbi.nlm.nih.gov/31125451
https://pubmed.ncbi.nlm.nih.gov/31125451