Zobrazeno 1 - 10
of 588
pro vyhledávání: '"Jay S. Wunder"'
Autor:
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112578- (2023)
Summary: Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, sug
Externí odkaz:
https://doaj.org/article/9cb3c9ca6c2240379dd61634e40c1c8c
Autor:
Kim M. Tsoi, Nalan Gokgoz, Paige Darville-O'Quinn, Patrick Prochazka, Ainaz Malekoltojari, Anthony M. Griffin, Peter C. Ferguson, Jay S. Wunder, Irene L. Andrulis
Publikováno v:
Bone & Joint Research, Vol 10, Iss 9, Pp 602-610 (2021)
Aims: Cell-free DNA (cfDNA) and circulating tumour DNA (ctDNA) are used for prognostication and monitoring in patients with carcinomas, but their utility is unclear in sarcomas. The objectives of this pilot study were to explore the prognostic signif
Externí odkaz:
https://doaj.org/article/a6e0838cdcba4748a65761405ec7b170
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su
Externí odkaz:
https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
Autor:
Axel Sahovaler, MD, Michael J. Daly, PhD, Harley H.L. Chan, PhD, Prakash Nayak, MD, Sharon Tzelnick, MD, Michelle Arkhangorodsky, BSc, Jimmy Qiu, MASc, Robert Weersink, PhD, Jonathan C. Irish, MD, MSc, FRCSC, Peter Ferguson, MD, MSc, FRCSC, Jay S. Wunder, MD, MSc, FRCSC
Publikováno v:
JBJS Open Access, Vol 7, Iss 2 (2022)
Background:. Computer-assisted surgery (CAS) can improve surgical precision in orthopaedic oncology. Accurate alignment of the patient’s imaging coordinates with the anatomy, known as registration, is one of the most challenging aspects of CAS and
Externí odkaz:
https://doaj.org/article/76a280ec3bd64bc7bc24d40e9ecf2f48
Autor:
Sinthu Pathmanapan, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzymes on cellular meta
Externí odkaz:
https://doaj.org/article/748bddafda024403a2e65a48d6597085
Autor:
Ahmed Aoude, David Nikomarov, Jonathan R. Perera, Izuchukwu K. Ibe, Anthony M. Griffin, Kim M. Tsoi, Peter C. Ferguson, Jay S. Wunder
Publikováno v:
The Bone & Joint Journal. :559-567
AimsGiant cell tumour of bone (GCTB) is a locally aggressive lesion that is difficult to treat as salvaging the joint can be associated with a high rate of local recurrence (LR). We evaluated the risk factors for tumour relapse after treatment of a G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a8a4438bf8e9f305393c59d69f246
https://doi.org/10.1302/0301-620x.105b5.bjj-2022-1231.r1
https://doi.org/10.1302/0301-620x.105b5.bjj-2022-1231.r1
Autor:
Alexander L. Lazarides, Harrison R. Ferlauto, Zachary D. C. Burke, Anthony M. Griffin, Bruce D. Leckey, Nicholas M. Bernthal, Jay S. Wunder, Peter C. Ferguson, Julia D. Visgauss, Brian E. Brigman, William C. Eward
Publikováno v:
Sarcoma, Vol 2021 (2021)
Synopsis. For ALTs, the utility of chest surveillance has not been well defined. This study suggests that chest imaging does not have a significant role in the surveillance of ALTs. Advanced local imaging and more intensive chest surveillance may be
Externí odkaz:
https://doaj.org/article/0714ad67646f473ab52d82be9bf8c10e
Autor:
Rostislav Novak, Jennifer L. Nevin, Philip D. Rowell, Anthony Griffin, Sergey Mazin, Stefan O. P. Hofer, Anne C. O’Neill, Kim Tsoi, Peter C. Ferguson, Jay S. Wunder
Publikováno v:
Annals of Surgical Oncology. 30:3701-3711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58480071e17038030c5e87aea0e00a29
https://doi.org/10.1245/s10434-023-13261-5
https://doi.org/10.1245/s10434-023-13261-5
Autor:
Ibrahim Alshaygy, Jean-Camille Mattei, Georges Basile, Anthony M. Griffin, Rebecca A. Gladdy, Carol J. Swallow, Brendan C. Dickson, Jay S. Wunder, Peter C. Ferguson
Publikováno v:
Annals of Surgical Oncology. 30:3106-3113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70bf65e078c5e187549efdec3d9601f1
https://doi.org/10.1245/s10434-022-12953-8
https://doi.org/10.1245/s10434-022-12953-8
Autor:
Jay S. Wunder, Minji J. Lee, Junghyun Nam, Beatrice Y. Lau, Brendan C. Dickson, Dushanthi Pinnaduwage, Shelley B. Bull, Peter C. Ferguson, Andrew Seto, Nalan Gokgoz, Irene L. Andrulis
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immune checkpoint proteins, such as PD-L1 and PD-1, are important in several cancers; however, their role in osteosarcoma (OSA) and soft tissue sarcoma (STS) remains unclear. Our aims were to determine whether subsets of OSA/STS harbor tumor-infiltra
Externí odkaz:
https://doaj.org/article/0026928f059a4331a52a64db61b3b10a