Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jay S. Trivedi"'
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)
Autor:
Miller Raymond E, Wei Huang, Horng-Chih Huang, Jay S. Trivedi, Scott R. Both, Nigam P. Rath, David B. Reitz, Deborah A. Mischke, Len F. Lee, Samuel J. Tremont, Steve R. Rapp, Danny J. Garland, Claude Jones, Banerjee Shyamal C, Matthew W. Mahoney, Theresa Fletcher, Michael B. Tollefson, Karen Regina, Emily J. Reinhard, Grace M. Wagner, Mark E. Smith, Judy Beaudry, J.-H Li, Kevin C. Glenn, Bradley T. Keller, Robert E. Manning, Kevin J. Koeller, Joe R. Schuh, Kolodziej Steve A, William F. Vernier, Carpenter Andrew J, Ching-Cheng Wang
Publikováno v:
Journal of Medicinal Chemistry. 48:5853-5868
In the preceding paper several compounds were reported as potent apical sodium-codependent bile acid transporter (ASBT) inhibitors. Since the primary site for active bile acid reabsorption is via ASBT, which is localized on the luminal surface of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8126ad3914a164ee565779032f3a9bd
https://doi.org/10.1021/jm0402162
https://doi.org/10.1021/jm0402162
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)
Autor:
Len F. Lee, James C. B. Li, William F. Vernier, Samuel J. Tremont, Miller Raymond E, Claude Jones, Wei Huang, Kevin J. Koeller, Robert E. Manning, Andrew J. Carpenter, Mark E. Smith, Scott R. Both, Nigam P. Rath, Joe R. Schuh, Michael B. Tollefson, Jay S. Trivedi, Danny J. Garland, Emily J. Reinhard, Deborah A. Mischke, Karen Regina, David B. Reitz, Grace M. Wagner, Ching-Cheng Wang, Kolodziej Steve A, Kevin C. Glenn, Keller Bradley T, Steve R. Rapp, Banerjee Shyamal C, Theresa R. Fletcher, Horng-Chih Huang, Judy Beaudry, Matthew W. Mahoney
Publikováno v:
Journal of Medicinal Chemistry. 48:5837-5852
Elevated plasma levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for atherosclerosis leading to coronary artery disease (CAD), which remains the main cause of mortality in Western society. We believe that by preventing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb4d79f2a819622faa896314c94f38
https://doi.org/10.1021/jm040215+
https://doi.org/10.1021/jm040215+
Publikováno v:
Drug Development Research. 63:151-160
Subcutaneous insulin has been used to treat diabetes since the discovery of insulin itself. However, despite a number of different formulations and routes of administration, intensive insulin therapy without limitations, such as too low bioavailabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f35cfe0fa5d556a5954a31c6c505f5d
https://doi.org/10.1002/ddr.10426
https://doi.org/10.1002/ddr.10426
Autor:
Jay S. Trivedi, Stephen P. Arneric, Sherry Carroll, Steven L. Krill, Yihong Qiu, Kennan C. Marsh, Kolette M. Flood
Publikováno v:
International Journal of Pharmaceutics. 157:43-52
ABT-089 is a potent cholinergic channel modulator under investigation for treatment of cognitive disorders. It is a highly water soluble compound with a short elimination half-life of 1.7 h in dogs. Hydrophilic and hydrophobic matrix systems were des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45c4d194ae80b0f960a4d2acb93bf52
https://doi.org/10.1016/s0378-5173(97)00215-9
https://doi.org/10.1016/s0378-5173(97)00215-9
Autor:
Mark W. Holladay, Kennan C. Marsh, Jay S. Trivedi, Jeffrey E. Campbell, Philip J. Johnson, Ellen M. Roberts, Yihong Qui, James P. Sullivan, Nan-Horng Lin, Bud Peterson, Michael Williams, A. David Rodrigues, Sherry Carroll, Stephen P. Arneric, Jerome F. Daanen
Publikováno v:
Drug Development Research. 41:31-43
ABT-089 [3-(2(S)-pyrrolidinylmethoxy)-2-methylpyridine] is a cholinergic channel modulator (ChCM) that selectively affects the function of neuronal nicotine acetylcholine receptor (nAChR) subtypes, enhances cognitive performance and has neuroprotecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4530762cfa61e1f92659ee5cc75172
https://doi.org/10.1002/(sici)1098-2299(199705)41:1<31::aid-ddr4>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199705)41:1<31::aid-ddr4>3.0.co
Publikováno v:
Journal of Pharmaceutical Sciences. 85:773-780
The crystal polymorphism of Abbott-79175, a potent second-generation 5-lipoxygenase inhibitor, has been studied. Crystallization from an ethyl acetate/heptane system in which moisture content was not controlled and from an ethanol/water system produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a140e6514084e1497abf816547ed53a
https://doi.org/10.1021/js950055c
https://doi.org/10.1021/js950055c
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:109-116
Zileuton (ABT-077) is a 5-lipoxygenase inhibitor with poor aqueous solubility. Using an extreme vertices experimental design and an empirical response surface analysis, both the solubility and pseudo-first-order degradation rate constants of zileuton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5bab0803250de89589edef51297c1de
https://doi.org/10.1016/0928-0987(95)00038-0
https://doi.org/10.1016/0928-0987(95)00038-0
Autor:
Jay S. Trivedi, James J. Fort
Publikováno v:
International Journal of Pharmaceutics. 123:217-227
The degradation kinetics of Abbott-79175 in aqueous solution have been studied as a function of pH. Concentration/time plots indicated a pseudo-first order nature of reactions throughout the pH range studied. Additionally, the effects of temperature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d70433ee61aeed3a85cf99afcb2c608
https://doi.org/10.1016/0378-5173(95)00063-o
https://doi.org/10.1016/0378-5173(95)00063-o
Publikováno v:
European Journal of Pharmaceutical Sciences. 3:241-243
Vitamin E (α-tocopherol) has demonstrated effectiveness as a human skin penetration enhancer by increasing the permeability coefficient of radiolabeled hydrocortisone approximately two-fold in excised cadaver skin. Skin permeability experiments were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d6678950883e86f2cfd94ce040035ce
https://doi.org/10.1016/0928-0987(95)00014-5
https://doi.org/10.1016/0928-0987(95)00014-5
Autor:
Jay S. Trivedi, Peter T. Mayer, Armin H. Gerhardt, Robert J. Schilling, James J. Fort, Yihong Qiu, Jacqueline Briskin
Publikováno v:
Drug development and industrial pharmacy. 28(3)
ABT-761 is a 5-lipoxygenase inhibitor developed for the treatment of asthma. The present study was undertaken to evaluate different crystal forms of ABT-761 and their impact on in vitro and in vivo performance in capsule formulations. Two crystal for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3d0fddcadea3d8b951e31214620106
https://pubmed.ncbi.nlm.nih.gov/12026221
https://pubmed.ncbi.nlm.nih.gov/12026221