Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jay S. Barbor"'
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7
Autor:
Divya Hosangadi, Lucas R. Morin, Kristie L. Connolly, Terry L. Bowlin, Michelle M. Butler, Christine M. Dunham, Atousa Mehrani, Zachary D. Aron, Jay S. Barbor, John N. Alumasa, Pooja Srinivas, Kenneth C. Keiler, Eric D. Hoffer, Mynthia Cabrera, Matthew C. Torhan, Scott M. Stagg, Steven M. Kwasny, Timothy J. Opperman, Ann E. Jerse, Steven C. Cardinale
The trans-translation pathway for rescuing stalled ribosomes is conserved and essential in bacterial pathogens but has no mammalian homolog, making it an ideal target for new antibiotics. We previously reported the discovery of a family of acylaminoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c60f516b4139e9bac172634fa60d14b
https://doi.org/10.1101/2020.06.04.132530
https://doi.org/10.1101/2020.06.04.132530
