Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jay S Lillquist"'
Autor:
Diego Alvarado, Gwenda F Ligon, Jay S Lillquist, Scott B Seibel, Gerald Wallweber, Veronique M Neumeister, David L Rimm, Gerald McMahon, Theresa M LaVallee
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181356 (2017)
Head and neck squamous cell carcinoma (HNSCC) accounts for 3-5% of all tumor types and remains an unmet medical need with only two targeted therapies approved to date. ErbB3 (HER3), the kinase-impaired member of the EGFR/ErbB family, has been implica
Externí odkaz:
https://doaj.org/article/c695b6e9947349e89cb6ca4cd1d6440e
Autor:
Tibor Keler, Lawrence J. Thomas, Colleen Patterson, Edward J. Natoli, Russell A. Hammond, Joel Goldstein, Laura Mills-Chen, Taylor Mathieu, Jeffrey Weidlick, Michael B. Murphy, Crystal Sisson, Diego Alvarado, Eric Forsberg, James M. Boyer, Li-Zhen He, Linda Crew, Jay S. Lillquist, Jenifer Widger, Thomas O'Neill, Henry March, Andrea Crocker, Amelia Fields, Anna Wasiuk, April R. Baronas, Laura Vitale
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Axl is a member of the TAM (Tyro3/Axl/MerTK) family of receptor tyrosine kinases and a negative regulator of innate immunity. Activation of Axl through its ligand Gas6 leads to suppression of myeloid cell activity, while its activation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5894ba27b16d12cef0d11b14ce02d5
https://doaj.org/article/c5b3f02237404c0b84026e473386f585
https://doaj.org/article/c5b3f02237404c0b84026e473386f585
Autor:
Linda Crew, Zeyu Peng, Thomas O'Neill, James L. Boyer, Mark Z. Ma, Michael T. Murphy, Lawrence J. Thomas, Jeff Weidlick, Colleen Patterson, Russell A. Hammond, Diego Alvarado, Anna Wasiuk, April R. Baronas, Joel Goldstein, Laura Mills-Chen, Tibor Keler, Andrea Crocker, Jay S. Lillquist, Jenifer Widger, Laura Vitale, Ed Natoli, Collin Xia, Henry C. Marsh, Hugh Davis
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A833-A833
BackgroundActivation of the ITIM-bearing ILT4/LILRB2 receptor by its cognate ligands (HLA-G and HLA Class I) has been postulated as a resistance mechanism for checkpoint blockade of PD-1 and CTLA-4. Dual inhibition of receptors that suppress myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a46fa79c93a7939d7fedcd55b405b1
https://doi.org/10.1136/jitc-2021-sitc2021.798
https://doi.org/10.1136/jitc-2021-sitc2021.798
Autor:
Tibor Keler, Colleen Patterson, Laura Mills-Chen, James L. Boyer, Thomas O'Neill, Anna Wasiuk, Diego Alvarado, Andrea Crocker, Michael T. Murphy, Joel Goldstein, Lawrence J. Thomas, Linda Crew, Jay S. Lillquist, Jenifer Widger, Edward J. Natoli, Henry C. Marsh, Jeff Weidlick, Laura Vitale
Publikováno v:
Cancer Research. 81:1865-1865
Activation of innate immunity using targeted therapies has become an attractive approach to stimulate antitumor responses. Dual inhibition of receptors that suppress myeloid and T cell compartments through the generation of bispecific antibodies (bsA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7b3817e4b60b31879adf5e36e81fc0
https://doi.org/10.1158/1538-7445.am2021-1865
https://doi.org/10.1158/1538-7445.am2021-1865
Autor:
Yael P. Mosse, Colleen Larmour, Jay S. Lillquist, Bruce R. Pawel, Ulisse Cucchi, Kateryna Krytska, Diego Alvarado, Paolo Orsini, Pichai Raman, Daniel Martinez, Simona Rizzi, Gwenda F. Ligon, Renata Sano
Publikováno v:
Sci Transl Med
Enthusiasm for the use of antibody-drug conjugates (ADCs) in cancer therapy has risen over the past few years. The success of this therapeutic approach relies on the identification of cell surface antigens that are widely and selectively expressed on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114a7581e07926f87809156fd324426d
https://doi.org/10.1126/scitranslmed.aau9732
https://doi.org/10.1126/scitranslmed.aau9732
Autor:
Gwenda F. Ligon, Theresa LaVallee, Veronique Neumeister, David L. Rimm, Diego Alvarado, Jay S. Lillquist, Gerald McMahon, Scott Seibel, Gerald J. Wallweber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181356 (2017)
PLoS ONE, Vol 12, Iss 7, p e0181356 (2017)
Head and neck squamous cell carcinoma (HNSCC) accounts for 3-5% of all tumor types and remains an unmet medical need with only two targeted therapies approved to date. ErbB3 (HER3), the kinase-impaired member of the EGFR/ErbB family, has been implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20649fc7fae54c2c592716730cc57e8b
http://europepmc.org/articles/PMC5517012
http://europepmc.org/articles/PMC5517012
Autor:
Andrew Proffitt, Komal Patel, Anna Wasiuk, Li-Zhen He, Richard Gedrich, Colleen Patterson, Andrea Crocker, Gwenda F. Ligon, Laura Mills-Chen, Russell A. Hammond, Tibor Keler, Henry C. Marsh, Lawrence J. Thomas, Diego Alvarado, Jay S. Lillquist, Jenifer Widger, Thomas O'Neill, Joel Goldstein, Michael T. Murphy, Jeff Weidlick, Laura Vitale
Publikováno v:
Cancer Research. 79:1555-1555
The TAM receptors (Tyro3/Axl/MerTK) family of receptor tyrosine kinases (RTKs) are important negative regulators of innate immunity. TAM receptor activation in myeloid cells by its ligands Gas6 or Protein S (PROS) promotes phosphatidylserine-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d67f5089c153da3e398bc4bfe975807
https://doi.org/10.1158/1538-7445.am2019-1555
https://doi.org/10.1158/1538-7445.am2019-1555
Autor:
Joel Goldstein, Laura Mills-Chen, Li-Zhen He, Lawrence J. Thomas, Michael T. Murphy, Richard Gedrich, Andrew Proffitt, Karuna Sundarapandiyan, Biwei Zhao, Diego Alvarado, Venky Ramakrishna, Colleen Patterson, James R. Storey, Craig Polson, Russell A. Hammond, Henry C. Marsh, Thomas O'Neill, Laura Vitale, Gwenda F. Ligon, Jay S. Lillquist, Jenifer Widger, Andrea Crocker, Tibor Keler
Publikováno v:
Molecular Cancer Therapeutics. 17:B194-B194
Members of the TAM family of receptor tyrosine kinases (RTKs) play important roles in tumorigenesis and homeostatic regulation of the immune system. Two closely related ligands, Protein S (PROS1) and Growth Arrest Specific 6 (GAS6), bind and activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1c5dd9a0f8c8ae61ff4e1bd806566a9
https://doi.org/10.1158/1535-7163.targ-17-b194
https://doi.org/10.1158/1535-7163.targ-17-b194
Autor:
Sangwon Lee, Diego Alvarado, Jay S. Lillquist, Gwenda F. Ligon, Edward J. Natoli, Yaron R. Hadari, Joseph Amick, Joseph Schlessinger, Etienne B Greenlee
ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231fbe8e10bf4d048f380dff10a0a5b7
https://europepmc.org/articles/PMC4629334/
https://europepmc.org/articles/PMC4629334/
Autor:
Edward J. Natoli, Gwenda F. Ligon, Xiarong Shi, Irit Lax, Ewa Folta-Stogniew, Joseph Schlessinger, Andrey V. Reshetnyak, Jay S. Lillquist, Diego Alvarado, Murat Gunel, Phillip B. Murray
Publikováno v:
Science Signaling. 8
Anaplastic lymphoma kinase (ALK) is one of the few remaining "orphan" receptor tyrosine kinases (RTKs) in which the ligands are unknown. Ligand-mediated activation of RTKs is important throughout development. ALK is particularly relevant to the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c7d90cd088b481b277dec5579eb096
https://doi.org/10.1126/scisignal.2005916
https://doi.org/10.1126/scisignal.2005916