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Akademický článek

Dysregulation of club cell biology in idiopathic pulmonary fibrosis.

Autor: Wu-Lin Zuo, Mahboubeh R Rostami, Michelle LeBlanc, Robert J Kaner, Sarah L O'Beirne, Jason G Mezey, Philip L Leopold, Karsten Quast, Sudha Visvanathan, Jay S Fine, Matthew J Thomas, Ronald G Crystal

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0237529 (2020)

Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of lung function. "Bronchiolization", characterized by ectopic appearance of airway epithelial cells in the alveolar regions, is one of t

Externí odkaz: https://doaj.org/article/0145c5d89b5d45929b0413cd0eb395e9

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Akademický článek

Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation.

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0120824 (2015)

Even after quitting smoking, the risk of the development of chronic obstructive pulmonary disease (COPD) and lung cancer remains significantly higher compared to healthy nonsmokers. Based on the knowledge that COPD and most lung cancers start in the

Externí odkaz: https://doaj.org/article/1b6f44e9a64d47daab4df117cf0df208

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Akademický článek

Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for 'active' disease.

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e59348 (2013)

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As

Externí odkaz: https://doaj.org/article/f1de7e184b004255ba62f718b13adc00

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Akademický článek

Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity.

Autor: Debra A Cockayne, Donavan T Cheng, Benjamin Waschki, Sriram Sridhar, Palanikumar Ravindran, Holly Hilton, Galina Kourteva, Hans Bitter, Sreekumar G Pillai, Sudha Visvanathan, Kai-Christian Müller, Olaf Holz, Helgo Magnussen, Henrik Watz, Jay S Fine

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38629 (2012)

The identification and validation of biomarkers to support the assessment of novel therapeutics for COPD continues to be an important area of research. The aim of the current study was to identify systemic protein biomarkers correlated with measures

Externí odkaz: https://doaj.org/article/d670836d162341129c02f54fff4b294d

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Imbalance between IL-36 receptor agonist and antagonist drives neutrophilic inflammation in COPD

Autor: H. B. Owles, P. J. Barnes, Sarah L. Elkin, M.J. Thomas, K. C. El-Kasmi, C. K. Coss, Louise E. Donnelly, Peter Fenwick, Jay S. Fine, Jonathan R. Baker

Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating novel therapies. Here, we show that COPD patients have increased IL-36γ and decreased IL-36 recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66a6bbdf52c71b8395014de9ed717e7
http://hdl.handle.net/10044/1/97997

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The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 321(5)

Mouse and human data implicate the NOD1 and NOD2 sensors of the intestinal microbiome and the associated signal transduction via the receptor interacting protein kinase 2 (RIPK2) as a potential key signaling node for the development of inflammatory b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249fa75449d8f623e54320bcf73b527e
https://pubmed.ncbi.nlm.nih.gov/34494462

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