Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Jay R Hesselberth"'
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001077 (2021)
Single-cell RNA sequencing (scRNA-seq) provides an unprecedented view of cellular diversity of biological systems. However, across the thousands of publications and datasets generated using this technology, we estimate that only a minority (
Externí odkaz:
https://doaj.org/article/42d096b161074f7ea67e1fd927da2edb
Autor:
Shannon M Walsh, Ryan M Sheridan, Erin D Lucas, Thu A Doan, Brian C Ware, Johnathon Schafer, Rui Fu, Matthew A Burchill, Jay R Hesselberth, Beth Ann Jiron Tamburini
Publikováno v:
eLife, Vol 10 (2021)
The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a com
Externí odkaz:
https://doaj.org/article/e1a779a5cbfd4b2eb30dfea75847fa35
Publikováno v:
eLife, Vol 8 (2019)
In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity. During the budding yeast UPR, Ire1 excises an intron from the HAC1 mRNA and the exon products
Externí odkaz:
https://doaj.org/article/12d9e817893c4dc38211a946456a18cd
Autor:
Erik C Hansen, Monica Ransom, Jay R Hesselberth, Nina N Hosmane, Adam A Capoferri, Katherine M Bruner, Ross A Pollack, Hao Zhang, Michael Bradley Drummond, Janet M Siliciano, Robert Siliciano, James T Stivers
Publikováno v:
eLife, Vol 5 (2016)
We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mut
Externí odkaz:
https://doaj.org/article/db3a368d8fbf4bbfb556874b4bc89f4b
Publikováno v:
eLife, Vol 4 (2015)
During hibernation, animals cycle between torpor and arousal. These cycles involve dramatic but poorly understood mechanisms of dynamic physiological regulation at the level of gene expression. Each cycle, Brown Adipose Tissue (BAT) drives periodic a
Externí odkaz:
https://doaj.org/article/7233250cf5484fa4bff6f9e462b93b4e
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-3 (2010)
Externí odkaz:
https://doaj.org/article/1d627887ed5f4156ba4ef538e55139b5
Publikováno v:
RNA. 29:847-861
Ligation by plant and fungal RNA ligases yields an internal 2′-phosphate group on each RNA ligation product. In budding yeast, this covalent mark occurs at the splice junction of two targets of ligation: intron-containing tRNAs and the messenger RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b6866fcef3d6bad8f94ead8e648a42
https://doi.org/10.1261/rna.079290.122
https://doi.org/10.1261/rna.079290.122
Autor:
Austin E. Gillen, Kent A. Riemondy, Vladimir Amani, Andrea M. Griesinger, Ahmed Gilani, Sujatha Venkataraman, Krishna Madhavan, Eric Prince, Bridget Sanford, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Ken L. Jones, Siddhartha Mitra, Jay R. Hesselberth, Nicholas K. Foreman, Andrew M. Donson
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108023- (2020)
Summary: Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development
Externí odkaz:
https://doaj.org/article/86aaa43b961a406abbb08113d63ce8d6
Autor:
Beth A. Jiron Tamburini, Jeffrey M. Finlon, Austin E. Gillen, Michael S. Kriss, Kent A. Riemondy, Rui Fu, Ronald P. Schuyler, Jay R. Hesselberth, Hugo R. Rosen, Matthew A. Burchill
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Liver lymphatic vessels support liver function by draining interstitial fluid, cholesterol, fat, and immune cells for surveillance in the liver draining lymph node. Chronic liver disease is associated with increased inflammation and immune cell infil
Externí odkaz:
https://doaj.org/article/d29ecb98b02b49bc805850487ed15d2d
Autor:
Laura K. White, Jay R. Hesselberth
Publikováno v:
Frontiers in genetics. 13
Next generation sequencing (NGS) has provided biologists with an unprecedented view into biological processes and their regulation over the past 2 decades, fueling a wave of development of high throughput methods based on short read DNA and RNA seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf06537cf42cbe34d8d91aa8c262d8
https://pubmed.ncbi.nlm.nih.gov/36386798
https://pubmed.ncbi.nlm.nih.gov/36386798