Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jay R Gibson"'
Publikováno v:
eLife, Vol 10 (2021)
Reduced structural and functional interhemispheric connectivity correlates with the severity of Autism Spectrum Disorder (ASD) behaviors in humans. Little is known of how ASD-risk genes regulate callosal connectivity. Here, we show that Fmr1, whose l
Externí odkaz:
https://doaj.org/article/cbcb8f96294c4adb9f85553155a47986
Publikováno v:
eLife, Vol 6 (2017)
Experience and activity refine cortical circuits through synapse elimination, but little is known about the activity patterns and downstream molecular mechanisms that mediate this process. We used optogenetics to drive individual mouse CA1 hippocampa
Externí odkaz:
https://doaj.org/article/e59d3ffd427649028d0db9d4c3b414c7
Autor:
Cara Jean Westmark, Shih-Chieh Chuang, Seth A Hays, Mikolaj J Filon, Brian C Ray, Pamela R Westmark, Jay R Gibson, Kimberly M Huber, Robert KS Wong
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1KO mice. Normalization of APP levels in Fmr1KO mice (Fmr1KO/APPHET mice) rescues many disease phen
Externí odkaz:
https://doaj.org/article/d4bdf3c5289c432ea68a2eeea7089524
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140638 (2015)
A single, maternally inherited, X-linked point mutation leading to an arginine to cysteine substitution at amino acid 451 (R451C) of Neuroligin 3 (NLGN3R451C) is a likely cause of autism in two brothers. Knockin mice expressing the Nlgn3R451C mutatio
Externí odkaz:
https://doaj.org/article/672808c055e142e080869cdecd078b5a
Autor:
Newaz I. Ahmed, Nitin Khandelwal, Ashley G. Anderson, Emily Oh, Rachael M. Vollmer, Ashwinikumar Kulkarni, Jay R. Gibson, Genevieve Konopka
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114257- (2024)
Summary: Spiny projection neurons (SPNs) of the striatum are critical in integrating neurochemical information to coordinate motor and reward-based behavior. Mutations in the regulatory transcription factors expressed in SPNs can result in neurodevel
Externí odkaz:
https://doaj.org/article/42976b5dd11e443caac22465340ef25b
Autor:
Gemma Molinaro, Jacob E. Bowles, Katilynne Croom, Darya Gonzalez, Saba Mirjafary, Shari G. Birnbaum, Khaleel A. Razak, Jay R. Gibson, Kimberly M. Huber
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114056- (2024)
Summary: Little is known of the brain mechanisms that mediate sex-specific autism symptoms. Here, we demonstrate that deletion of the autism spectrum disorder (ASD)-risk gene, Pten, in neocortical pyramidal neurons (NSEPten knockout [KO]) results in
Externí odkaz:
https://doaj.org/article/7c73a4c9eb664f3cb970e1280a5f33cf
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 563-572 (2019)
Electroencephalogram (EEG) recordings in Fragile X syndrome (FXS) patients have revealed enhanced sensory responses, enhanced resting “gamma frequency” (30–100 Hz) activity, and a decreased ability for sensory stimuli to modulate cortical activ
Externí odkaz:
https://doaj.org/article/e312ec1af5f24dbfa8dde270e61044ce
Autor:
Tori L. Schaefer, Amy A. Ashworth, Durgesh Tiwari, Madison P. Tomasek, Emma V. Parkins, Angela R. White, Andrew Snider, Matthew H. Davenport, Lindsay M. Grainger, Robert A. Becker, Chandler K. Robinson, Rishav Mukherjee, Michael T. Williams, Jay R. Gibson, Kimberly M. Huber, Christina Gross, Craig A. Erickson
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability. FXS is caused by functional loss of the Fragile X Protein (FXP), also known as Fragile X Mental Retardation Protein (FMRP). In humans and animal models, loss of F
Externí odkaz:
https://doaj.org/article/33d1af00c9a14d4d9325ec5c3d066655
Autor:
Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Jay R. Gibson, Yingfei Wang
Publikováno v:
Mol Psychiatry
The excitatory neurotransmitter glutamate shapes learning and memory, but the underlying epigenetic mechanism of glutamate regulation in neuron remains poorly understood. Here, we showed that lysine demethylase KDM6B was expressed in excitatory neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee03c8866b63477c51bbd88598435f9
https://europepmc.org/articles/PMC10108576/
https://europepmc.org/articles/PMC10108576/
Autor:
Ashley G. Anderson, Genevieve Konopka, Ashwinikumar Kulkarni, Jay R. Gibson, Volodymyr Rybalchenko, Sheridan Cavalier, Nitin Khandelwal
Publikováno v:
Mol Psychiatry
Heterozygous loss-of-function mutations in the transcription factor FOXP1 are strongly associated with autism. Dopamine receptor 2 expressing (D2) striatal projection neurons (SPNs) in heterozygous Foxp1 (Foxp1+/−) mice have higher intrinsic excita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28f469cd241323724f404c1b2c756f9
https://doi.org/10.1038/s41380-020-00995-x
https://doi.org/10.1038/s41380-020-00995-x