Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Jay R, Kostman"'
Autor:
Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Radwa Sharaf, Behzad Etemad, Mohammad Damra, Aaron R. Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Alan Landay, Luis J. Montaner, Jeffrey M. Jacobson, Jonathan Z. Li, Mohamed Abdel-Mohsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning
Externí odkaz:
https://doaj.org/article/8389144aeb1a4d6d950f9fd144f01fe1
Autor:
Jessie Torgersen, Kaku So-Armah, Matthew S. Freiberg, Matthew B. Goetz, Matthew J. Budoff, Joseph K. Lim, Tamar Taddei, Adeel A. Butt, Maria C. Rodriguez-Barradas, Amy C. Justice, Jay R. Kostman, Vincent Lo Re
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Hepatic steatosis is prevalent in Western countries, but few studies have evaluated whether the frequency and severity of steatosis are greater in the setting of HIV infection. We compared the prevalence and severity of hepatic st
Externí odkaz:
https://doaj.org/article/a2833d9f2cee4f8da1c8cf136ad3f112
Autor:
Leila B. Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron R. Goldman, Hsin-Yao Tang, Clovis S. Palmer, Alan L. Landay, Jonathan Z. Li, John R. Koethe, Karam Mounzer, Jay R. Kostman, Qin Liu, Luis J. Montaner, Mohamed Abdel-Mohsen
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs. Therefore, there is a
Externí odkaz:
https://doaj.org/article/0fa9e9d892ae46d3801779a44629a2bb
Autor:
Leila B. Giron, Florent Colomb, Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Matthew Fair, Alitzel Anzurez, Mohammad Damra, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Una O'Doherty, Hiroaki Tateno, Qin Liu, Michael R. Betts, Luis J. Montaner, Mohamed Abdel-Mohsen
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102945- (2020)
Background: A comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding its detrimental side-effects during HIV infection. Cytokines modula
Externí odkaz:
https://doaj.org/article/fab31996f60c46fa9d6c34db3d611550
Autor:
Pablo Tebas, Kenn Lynn, Livio Azzoni, Giorgio Cocchella, Emmanouil Papasavvas, Matthew Fair, Brijesh Karanam, Paridhima Sharma, Jacqueline D. Reeves, Christos J. Petropoulos, Linden Lalley-Chareczko, Jay R. Kostman, Willian Short, Karam Mounzer, Luis J. Montaner
Publikováno v:
AIDS.
Autor:
Emmanouil Papasavvas, Mohamed Abdel-Mohsen, Livio Azzoni, Brian N Ross, Bonnie J Howell, Pablo Tebas, Karam Mounzer, Matthew Fair, Qingsheng Li, Jay R. Kostman, Luis J. Montaner, Nicolas Chomont, Daria J. Hazuda, Amélie Pagliuzza
Publikováno v:
AIDS Res Hum Retroviruses
In the pilot NCT01935089 trial, we tested whether pegylated interferon alpha2b (Peg-IFN-α2b) with antiretroviral therapy (ART) was safe and could impact HIV and immune measures in blood and in gut-associated lymphoid tissue (GALT). Twenty HIV-1(+) A
Publikováno v:
In Hepatology 2001 34(4) Part 2:A330-A330
Autor:
Nicolas Chomont, Shih Lin Goh, Carolyn Bahnck-Teets, Paul Zuck, Bonnie J. Howell, Steven M. Lada, Amanda C Sciorillo, Douglas D. Richman, Mohammad Damra, Mohamed Abdel-Mohsen, Agnieszka Mackiewicz, Jay R. Kostman, Emmanouil Papasavvas, Amélie Pagliuzza, Pablo Tebas, Kwasi Gyampoh, Matthew Fair, Kenneth Lynn, Zhe Yuan, Karam Mounzer, Livio Azzoni, Guoxin Wu, Brian N Ross, Luis J. Montaner, Daniel J. Holder
Publikováno v:
Clin Infect Dis
Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays
Autor:
Mohamed Abdel-Mohsen, Livio Azzoni, Ian Sanne, Mohammad Damra, Xiangfan Yin, Luis J. Montaner, Cynthia Firnhaber, Leila B. Giron, Qin Liu, Hiroaki Tateno, Alitzel Anzurez, Emmanouil Papasavvas, Jay R. Kostman, Karam Mounzer
Publikováno v:
AIDS
Objective HIV cure research urgently needs to identify pre-analytic treatment interruption (ATI) biomarkers of time-to-viral-rebound and viral setpoint to mitigate the risk of ATI and accelerate development of a cure. We previously reported that gala
Autor:
Rowena Johnston, Aaron R. Goldman, Mohamed Abdel-Mohsen, Qin Liu, Jay R. Kostman, Clovis S. Palmer, Leila B. Giron, Emmanouil Papasavvas, Luis J. Montaner, Radwa Sharaf, Jonathan Z. Li, Pablo Tebas, Karam Mounzer, Jeffrey M. Jacobson, Xiangfan Yin, Mohammad Damra, Behzad Etemad, Hsin-Yao Tang, Alan L. Landay
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the host pat