Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jay P, Ross"'
Autor:
Zoe Schmilovich, Vincent-Raphaël Bourque, Elise Douard, Guillaume Huguet, Cécile Poulain, Jay P. Ross, Paria Alipour, Charles-Étienne Castonguay, Nadine Younis, Martineau Jean-Louis, Zohra Saci, Zdenka Pausova, Tomas Paus, Gunter Schuman, David Porteous, Gail Davies, Paul Redmond, Sarah E. Harris, Ian J. Deary, Heather Whalley, Caroline Hayward, Patrick A. Dion, Sébastien Jacquemont, Guy A. Rouleau
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionRare copy number variants (CNVs) and polygenic risk for intelligence (PRS-IQ) both confer susceptibility for autism spectrum disorder (ASD) but have opposing effects on cognitive ability. The field has struggled to disentangle the effects
Externí odkaz:
https://doaj.org/article/9d42e1c4950f40a680ea76ab28d013fb
Autor:
Paria Alipour, Konstantin Senkevich, Jay P. Ross, Dan Spiegelman, Despoina Manousaki, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-7 (2022)
Abstract Background Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disorders and ALS using Men
Externí odkaz:
https://doaj.org/article/b1f43af7833e4a98946c077590106e80
Autor:
Charles-Etienne Castonguay, Calwing Liao, Anouar Khayachi, Yumin Liu, Miranda Medeiros, Gabrielle Houle, Jay P. Ross, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified. Recent advances in pharmacogenomics have previously be
Externí odkaz:
https://doaj.org/article/a039ede0ce6a42c794df849f2ee72262
Autor:
Calwing Liao, Veikko Vuokila, Hélène Catoire, Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-6 (2022)
Calwing Liao and Veikko Vuokila et al. report a transcriptome-wide association study (TWAS) of Tourette’s Syndrome. They find increased expression of FLT3 in the dorsolateral prefrontal cortex and the lymphoblastoid cell lines in patients with Tour
Externí odkaz:
https://doaj.org/article/c55de6f7799640e488bf9c601ff989c6
Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.
Autor:
Yoshitaka Tamaki, Jay P Ross, Paria Alipour, Charles-Étienne Castonguay, Boting Li, Helene Catoire, Daniel Rochefort, Makoto Urushitani, Ryosuke Takahashi, Joshua A Sonnen, Stefano Stifani, Patrick A Dion, Guy A Rouleau
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010606 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43)
Externí odkaz:
https://doaj.org/article/95522895ecef4007a675cea94277e3f9
Autor:
Rossella Spataro, Maria Kousi, Sali M. K. Farhan, Jason R. Willer, Jay P. Ross, Patrick A. Dion, Guy A. Rouleau, Mark J. Daly, Benjamin M. Neale, Vincenzo La Bella, Nicholas Katsanis
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-10 (2019)
Abstract Background Amyotrophic lateral sclerosis [1] is a genetically heterogeneous neurodegenerative disorder, characterized by late-onset degeneration of motor neurons leading to progressive limb and bulbar weakness, as well as of the respiratory
Externí odkaz:
https://doaj.org/article/2ca1793b76fd4a3483f28594050062e2
Publikováno v:
F1000Research, Vol 9 (2020)
Over the past decade, exome sequencing (ES) has allowed significant advancements to the field of disease research. By targeting the protein-coding regions of the genome, ES combines the depth of knowledge on protein-altering variants with high-throug
Externí odkaz:
https://doaj.org/article/0924038d36b64010b97a86bed6d2f676
Autor:
Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Calwing Liao, Daniel Rochefort, Maria Thereza Drumond Gama, Marie-Josée Dicaire, Orlando G. Barsottini, Bernard Brais, José Luiz Pedroso, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
A biallelic pentanucleotide expansion in the RFC1 gene has been reported to be a common cause of late-onset ataxia. In the general population, four different repeat conformations are observed: wild type sequence AAAAG (11 repeats) and longer expansio
Externí odkaz:
https://doaj.org/article/3196f93a42ed4362ba5f64f66a72f8a3
Autor:
Faezeh Sarayloo, Alexandre Dionne-Laporte, Helene Catoire, Daniel Rochefort, Gabrielle Houle, Jay P Ross, Fulya Akçimen, Rachel De Barros Oliveira, Gustavo Turecki, Patrick A Dion, Guy A Rouleau
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225186 (2019)
Restless legs syndrome is a common complex disorder with different genetic and environmental risk factors. Here we used human cell lines to conduct an RNA-Seq study and observed how the gene showing the most significant association with RLS, MEIS1, a
Externí odkaz:
https://doaj.org/article/c09c9e6260a54b268d5adb635aca985a
Autor:
Zoe Schmilovich, Vincent-Raphaël Bourque, Guillaume Huguet, Qin He, Jay P. Ross, Martineau Jean-Louis, Zohra Saci, Boris Chaumette, Patrick A. Dion, Sébastien Jacquemont, Guy A. Rouleau
Compared to disorders of similar heritability and contribution of common variants, few genome-wide significant loci have been implicated in autism spectrum disorder (ASD). This undermines the use of polygenic risk scores (PRSs) to investigate the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9232f135258d0e5820c20fb91f54807
https://doi.org/10.1101/2023.05.23.23290405
https://doi.org/10.1101/2023.05.23.23290405
