Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jay M. Short"'
Autor:
Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTEpithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors. However, targeting EpCAM has been
Externí odkaz:
https://doaj.org/article/7fc31e7a3b674b338e4ac1b2672d0edf
Autor:
Wei Zhou, Ana Paula G Cugnetti, Mathew Lucas, Haizhen Liu, Charles Xing, Solimarie Joyner, Kyrie Johnson, Kathryn Woodard, Cathy Chang, Gerhard Frey, William J Boyle, Jay M Short, Patricia McNeeley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c6858652b2444bd089373159245edfe0
Autor:
Ana Paula Cugnetti, Haizhen Liu, Patricia McNeeley, Christina Wheeler, Matthew Lucas, Charles Xing, Solmarie Joyner, Kyrie Johnson, Kathryn Woodard, Wei Zhou, Cathy Chang, Gerhard Frey, William J. Boyle, Jay M. Short
Publikováno v:
Cancer Research. 83:1871-1871
Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers and is associated with poor prognosis. Despite the outstanding improvement in survival with the introduction of anti-HER2 therapies, therapeutic benefit is limited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a2926a3277340680bc66d79359b9725
https://doi.org/10.1158/1538-7445.am2023-1871
https://doi.org/10.1158/1538-7445.am2023-1871
Autor:
Jian Chen, Christina Wheeler, Jing Wang, Matt Lucas, Haizhen Liu, Kyrie Johnson, Kathryn Woodard, Solmarie Joyner, Cathy Chang, William J. Boyle, Jay M. Short
Publikováno v:
Cancer Research. 83:4795-4795
The aberrant accumulation of senescent cells in aged and cancerous tissue triggers inflammatory signaling through a senescence-associated secretory phenotype (SASP), promoting aging and tumor progression. Pharmacologically, clearing senescent cells h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3dd9d9e576ec46304cf176eec76a36c
https://doi.org/10.1158/1538-7445.am2023-4795
https://doi.org/10.1158/1538-7445.am2023-4795
Autor:
Matthew Lucas, Ana Paula Cugnetti, Haizhen Liu, Charles Xing, Jing Wang, Patricia McNeeley, Christina Wheeler, Solmarie Joyner, Kyrie Johnson, Kathryn Woodard, Wei Zhou, Cathy Chang, Gerhard Frey, William J. Boyle, Jay M. Short
Publikováno v:
Cancer Research. 83:1879-1879
Nectin-4 is a Ca2+ independent immunoglobulin-like protein that is primarily involved in cell-cell adhesion. Nectin-4 is overexpressed in several tumor types, including breast, lung, urothelial, colorectal, pancreatic, and ovarian cancers. Overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a44eab30e236b73c28c0d9faba07adee
https://doi.org/10.1158/1538-7445.am2023-1879
https://doi.org/10.1158/1538-7445.am2023-1879
Autor:
Jian Chen, Jing Wang, Matt Lucas, Haizhen Liu, Christina Wheeler, Kyrie Johnson, Kathryn Woodard, Cathy Chang, Gerhard Frey, William J. Boyle, Jay M. Short
Publikováno v:
Cancer Research. 83:B022-B022
Cellular senescence is characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment. The aberrant accumulation of senescent cells in aged and cancerous tissue triggers inflammatory signaling through a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cabda2af71c148b6a06b92afdb424331
https://doi.org/10.1158/1538-7445.agca22-b022
https://doi.org/10.1158/1538-7445.agca22-b022
Publikováno v:
Recombinant DNA Principles and Methodologies ISBN: 9781003067658
Recombinant DNA Principles and Methodologies
Recombinant DNA Principles and Methodologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee378f6b6d04fd78053a840c0d575f0
https://doi.org/10.1201/9781003067658-13
https://doi.org/10.1201/9781003067658-13
Autor:
Haizhen Liu, Hwai Wen Chang, Jay M. Short, Lawrence Steinman, Charles Xing, Gerhard Frey, William J. Boyle
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance On-target, off-tumor toxicity of anti-CTLA4 checkpoint inhibitors leads to severe adverse events, restricting therapeutic efficacy. We engineered anti-CTLA4 antibodies and generated a new class of antibodies referred to as conditionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4c6bbda6a8919c42326f6ffd949a00
https://doi.org/10.1073/pnas.2020606118
https://doi.org/10.1073/pnas.2020606118
Autor:
Christina Wheeler, Jing Wang, Haizhen Liu, Ana Paula G. Cugnetti, William J. Boyle, Jay M. Short, Cathy Chang, Charles Xing, Gerhard Frey, Matthew Lucas
Publikováno v:
Cancer Research. 81:1870-1870
The use of CD3/target bispecific molecules has great therapeutic potential in oncology. This potential, however, is diminished due to severe cytokine release effects as well as serious on-target off-tumor toxicities. Conditionally Active Biologic (CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a86cc1d4eff879c84e5f5eb2e44c3d
https://doi.org/10.1158/1538-7445.am2021-1870
https://doi.org/10.1158/1538-7445.am2021-1870
Autor:
Ana Paula G. Cugnetti, Matthew Lucas, Christina Wheeler, Haizhen Liu, Cathy Chang, Charles Xing, William J. Boyle, Jay M. Short, Jing Wang, Gerhard Frey
Publikováno v:
Cancer Research. 80:5698-5698
The use of CD3/target bispecific molecules has great therapeutic potential in oncology. This potential, however, is diminished due to serious on-target drug-related toxicities, restricting the development of bispecific T cell engagers to targets that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aed4097ea84080b9a75e849502e0ee6
https://doi.org/10.1158/1538-7445.am2020-5698
https://doi.org/10.1158/1538-7445.am2020-5698