Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Jay M. McDonald"'
Autor:
Shan-zhong Yang, Tong Zhou, Jay M. McDonald, Yabing Chen, Xinyang Zhao, Yong Sun, Kaiyu Yuan, Fei Xu
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
TRAIL-activating therapy is promising in treating various cancers, including pancreatic cancer, a highly malignant neoplasm with poor prognosis. However, many pancreatic cancer cells are resistant to TRAIL-induced apoptosis despite their expression o
Publikováno v:
The Journal of biological chemistry. 292(25)
Pancreatic cancer is a malignant neoplasm with a high mortality rate. Therapeutic agents that activate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis have shown promising efficacy, but many pancreatic cancers are resistant to TRAIL t
Autor:
Tong Zhou, Tiara Napier, Yuhua Song, Gu Jing, Romone M. Fancy, Jay M. McDonald, Lingyun Wang, Aaron L. Lucius, JiaBei Lin
Publikováno v:
Biochemistry
The Fas death receptor-activated death-inducing signaling complex (DISC) regulates apoptosis in many normal and cancer cells. Qualitative biochemical experiments demonstrate that calmodulin (CaM) binds to the death domain of Fas. The interaction betw
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:377-385
Fas binding to Fas-associated death domain (FADD) activates FADD-caspase-8 binding to form death-inducing signaling complex (DISC) that triggers apoptosis. The Fas-Fas association exists primarily as dimer in the Fas-FADD complex, and the Fas-FADD te
Publikováno v:
Laboratory Investigation. 92:82-90
We have previously demonstrated that calmodulin (CaM) binds directly to c-FLIP(L) in a Ca(2+)-dependent manner. Deletion of the CaM-binding region (amino acid 197-213) results in reduced CaM binding, and increased Fas-mediated apoptosis and decreased
Autor:
Paul Spearman, George Pan, Jianzhong Liu, PingAr Yang, John P. Clancy, Xu Feng, David A. Garber, Rui Zheng, Jay M. McDonald, Yao Li
Publikováno v:
Journal of Bone and Mineral Research. 26:1913-1925
The innate immune system and its components play an important role in the pathogenesis of inflammatory bone destruction. Blockade of inflammatory cytokines does not completely arrest bone erosion, suggesting that other mediators also may be involved
Autor:
Yabing Chen, Kaiyu Yuan, Yuebin Li, Hui Wu, Jay M. McDonald, Kui Zhang, Jianfeng Chen, Hui Liu, Gu Jing
Publikováno v:
Journal of Biological Chemistry. 286:24776-24784
Pancreatic cancer remains a devastating malignancy with a poor prognosis and is largely resistant to current therapies. To understand the resistance of pancreatic tumors to Fas death receptor-induced apoptosis, we investigated the molecular mechanism
Autor:
Gu Jing, Juan Pablo Arnoletti, Amy N. Turk, Jay M. McDonald, Yabing Chen, Nirag Jhala, Kui Zhang, Kaiyu Yuan
Publikováno v:
Laboratory Investigation. 91:896-904
Cholangiocarcinoma is a highly malignant tumor with limited therapeutic options. We have previously reported that tamoxifen (TMX) induces apoptosis of cholangiocarcinoma cells and reduces cholangiocarcinoma tumorigenesis in mice. In the present studi
Autor:
Xu Feng, Jay M. McDonald
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 6:121-145
The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone r
Publikováno v:
Annals of the New York Academy of Sciences. 1192:358-364
Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review,