Výsledky vyhledávání - "Jay M J R, Carr"

Cerebral endothelium-dependent function and reactivity to hypercapnia: the role of α1-adrenoreceptors

Autor: Jay M. J. R. Carr, Connor A. Howe, Travis D. Gibbons, Michael M. Tymko, Andrew R. Steele, Gustavo A. Vizcardo-Galindo, Joshua C. Tremblay, Philip N. Ainslie

Publikováno v: Journal of Applied Physiology. 133:1356-1367

We assessed steady-state hypercapnic cerebrovascular reactivity and cerebral endothelium-dependent function, with and without α1-adrenergic blockade (Prazosin), in a placebo-controlled, double-blind, and randomized study, to assess the contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf6c1d4ec9d556f2b8ec924615ffbd43
https://doi.org/10.1152/japplphysiol.00400.2022

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The stability of cerebrovascular CO 2 reactivity following attainment of physiological steady‐state

Autor: Ryan L. Hoiland, Kurt J. Smith, Michael M. Tymko, Philip N. Ainslie, Hannah G. Caldwell, Jay M. J. R. Carr, Daniel J. Green, Howard H. Carter

Publikováno v: Experimental Physiology. 106:2542-2555

New findings What is the central question of this study? During a steady-state cerebrovascular CO2 reactivity test, do different data extraction time points change the outcome for cerebrovascular CO2 reactivity? What is the main finding and its impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9345e298885c2be03574a8f0b342d86
https://doi.org/10.1113/ep089982

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Alterations in arterial CO 2 rather than pH affect the kinetics of neurovascular coupling in humans

Autor: Thompson G. Robinson, Connor A. Howe, Philip N. Ainslie, Courtney V. Brown, Jay M. J. R. Carr, Alexander Patrician, Jatinder S. Minhas, Ronney B. Panerai, Hannah G. Caldwell, Carter J. Chalifoux, Joshua C. Tremblay, Ryan L. Hoiland

Publikováno v: The Journal of Physiology. 599:3663-3676

KEY POINTS We investigated the influence of arterial PCO2 ( PaCO2 ) with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC). We assessed stepwise iso-oxic alterations in PaCO2 prior to and following intravenous NaHCO3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f844a71e8783cb033ea71d4def2306ac
https://doi.org/10.1113/jp281615

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Brachial artery responses to acute hypercapnia: The roles of shear stress and adrenergic tone

Autor: Jay M. J. R. Carr, Philip N. Ainslie, Connor A. Howe, Travis D. Gibbons, Michael M. Tymko, Andrew R. Steele, Ryan L. Hoiland, Gustavo A. Vizcardo‐Galindo, Alex Patrician, Courtney V. Brown, Hannah G. Caldwell, Joshua C. Tremblay

Publikováno v: Experimental physiologyREFERENCES. 107(12)

What is the central question of this study? What are the contributions of shear stress and adrenergic tone to brachial artery vasodilatation during hypercapnia? What is the main finding and its importance? In healthy young adults, shear-mediated vaso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c86be34d8b47b92987544665f4aabdf
https://pubmed.ncbi.nlm.nih.gov/36114662

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Cerebral blood flow, cerebrovascular reactivity and their influence on ventilatory sensitivity

Autor: Philip N. Ainslie, Jay M. J. R. Carr, Hannah G. Caldwell

Publikováno v: Experimental Physiology. 106:1425-1448

New findings What is the topic of this review? Cerebrovascular reactivity to CO2 is a principle factor in determining ventilatory responses to CO2 through the role reactivity plays in determining cerebral extra- and intra-cellular pH. What advances d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599868c5db24a1aa6924b3098d800552
https://doi.org/10.1113/ep089446

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Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia

Autor: Geoff B. Coombs, Connor A. Howe, Michael M. Tymko, Rachel Stone, Kaitlyn Tymko, Courtney Tymko, Jay M. J. R. Carr, Ryan L. Hoiland, Alexander Patrician, Philip N. Ainslie

Publikováno v: High Altitude Medicine & Biology. 21:297-302

Carr, Jay, Rachel Stone, Courtney Tymko, Kaitlyn Tymko, Geoff B. Coombs, Ryan L. Hoiland, Connor A. Howe, Michael M. Tymko, Philip N. Ainslie, and Alexander Patrician. Global REACH 2018: the effect...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c173fd1c792c02bac802c0c7a21635c5
https://doi.org/10.1089/ham.2019.0124

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Shearing the brain

Autor: Jay M. J. R. Carr, Philip N. Ainslie

Publikováno v: J Appl Physiol (1985)

Cyclic intermittent hypoxia (IH) increases cerebral blood velocity. This enhanced velocity augments the commensurate shear stimulus and may subsequently increase cerebrovascular endothelial function. This study aimed to examine the effects of cyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee97763726f6cc37b4a7bca0cbcd247
https://doi.org/10.1152/japplphysiol.00658.2020

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Cerebrovascular reactivity to carbon dioxide is not influenced by variability in the ventilatory sensitivity to carbon dioxide

Autor: Connor A. Howe, Ryan L. Hoiland, Daniela Nowak-Flück, Jay M. J. R. Carr, Philip N. Ainslie, Hannah G. Caldwell

Publikováno v: Experimental Physiology. 105:904-915

New findings What is the central question of this study? Do differing magnitudes of ventilation influence cerebrovascular CO2 reactivity and the cerebral blood flow response to increases in arterial carbon dioxide? What is the main finding and its im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c27c3a16f0808221de3874a94e8c692
https://doi.org/10.1113/ep088192

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