Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Jay M, Baltz"'
Publikováno v:
Cells, Vol 12, Iss 20, p 2500 (2023)
Early preimplantation mouse embryos are sensitive to increased osmolarity, which can block their development. To overcome this, they accumulate organic osmolytes to maintain cell volume. The main organic osmolyte used by early mouse embryos is glycin
Externí odkaz:
https://doaj.org/article/bde4555eb1b24d27a5aa92e13c11bff3
Autor:
Samantha Richard, Jay M. Baltz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract GLYT1-mediated glycine transport is the main cell volume-homeostatic mechanism in mouse eggs and early preimplantation embryos. It is unique to these developmental stages and key to their healthy development. GLYT1 first becomes activated in
Externí odkaz:
https://doaj.org/article/4a5037159ee54eedb418b20f0fb8cadd
Autor:
Kyla Young, Allison K. Tscherner, Baohua Zhang, Megan Meredith, Taylor McClatchie, Jacquetta M. Trasler, Jay M. Baltz
Publikováno v:
Zygote. 30:674-688
SummaryThe enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) links the folate cycle that produces one-carbon units with the methionine cycle that converts these into S-adenosylmethionine (SAM), the universal methyl donor for almost all methyltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a47e866a840bb42dff0c8e8feed602c
https://doi.org/10.1017/s0967199422000156
https://doi.org/10.1017/s0967199422000156
Publikováno v:
Biology of reproduction.
The fully grown mammalian oocyte is tightly attached to its extracellular matrix shell, the zona pellucida (ZP), but the oocyte detaches from the ZP shortly after ovulation is signaled. The mechanism by which the oocyte detaches from the ZP is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcfdcfb9aad08fffa3a3b4bb5366d00
https://pubmed.ncbi.nlm.nih.gov/36179245
https://pubmed.ncbi.nlm.nih.gov/36179245
Publikováno v:
Journal of Cellular Physiology. 236:7117-7133
The period beginning with the signal for ovulation, when a fully-grown oocyte progresses through meiosis to become a mature egg that is fertilized and develops as a preimplantation embryo, is crucial for healthy development. The early preimplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5068c72e36ecfe5e8332fcf877b5bfd7
https://doi.org/10.1002/jcp.30352
https://doi.org/10.1002/jcp.30352
Autor:
Gurbet Karahan, Kenjiro Shirane, Jay M. Baltz, Matthew C. Lorincz, Taylor McClatchie, Sanne M. Janssen, Jacquetta M. Trasler, Donovan Chan
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c3b783c67ef5dfe7337c62b41c51f
http://europepmc.org/articles/PMC8276981
http://europepmc.org/articles/PMC8276981
Publikováno v:
Zygote. 27:173-179
SummaryRecovery from decreased cell volume is accomplished by a regulated increase of intracellular osmolarity. The acute response is activation of inorganic ion transport into the cell, the main effector of which is the Na+/H+ exchanger NHE1. NHE1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0434b9c70d6514431b31743de9b4959e
https://doi.org/10.1017/s0967199419000212
https://doi.org/10.1017/s0967199419000212
Autor:
Taylor McClatchie, Megan Meredith, Mariame O. Ouédraogo, Sandy Slow, Michael Lever, Mellissa R.W. Mann, Steven H. Zeisel, Jacquetta M. Trasler, Jay M. Baltz
Publikováno v:
The Journal of biological chemistry. 295(31)
Betaine (N,N,N-trimethylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of cell volume regulation and second as a major methyl donor in blastocysts, but its origin is unknown. Here, we determined that end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07672e5a9aa7a9bf490ee7e09d1f1fc2
https://pubmed.ncbi.nlm.nih.gov/28663368
https://pubmed.ncbi.nlm.nih.gov/28663368
Publikováno v:
Journal of cellular physiologyREFERENCES. 235(11)
Serine has roles in cell metabolism besides protein synthesis including providing one-carbon units to the folate cycle. Since growing mouse oocytes undergo a burst of folate accumulation as they near full size, we have investigated whether oocytes tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6616a45a2b2f306a6e9ac55e6eb3237
https://pubmed.ncbi.nlm.nih.gov/32329057
https://pubmed.ncbi.nlm.nih.gov/32329057
Autor:
Zubin Master, Arthur Leader, Patrick Bedford, Maeghan Toews, Minh Thu Nguyen, Andrea Jurisicova, Yonida Koukio, Insoo Hyun, Erika Kleiderman, Ubaka Ogbogu, Amy Zarzeczny, Vardit Ravitsky, Yasmeen Jaafar, Jay M. Baltz, Forough Noohi, Jenny Du, Bartha Maria Knoppers
Publikováno v:
Healthcare Policy
Scopus-Elsevier
Scopus-Elsevier
Research involving human embryos and reproductive materials, including certain forms of stem cell and genetic research, is a fast-moving area of science with demonstrated clinical relevance. Canada's current governance framework for this field of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe2bee6fad3762627c12e03b8a25e1e
http://europepmc.org/articles/PMC5863866
http://europepmc.org/articles/PMC5863866