Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Jay L, Zweier"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: CD38 is a transmembrane glycoprotein that catabolizes nicotinamide adenine dinucleotide (NAD+) and is the main source for the age-dependent decrease in NAD+ levels. Increased CD38 enzymatic activity has been implicated in several neurolog
Externí odkaz:
https://doaj.org/article/2000f9805f9d49a2bf2beea6d965b34a
Autor:
Yousef Hannawi, Eder Caceres, Mohamed G. Ewees, Kimerly A. Powell, Anna Bratasz, Jan M. Schwab, Cameron L. Rink, Jay L. Zweier
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Introduction: Spontaneously hypertensive stroke-prone rats (SHRSP) are used to model clinically relevant aspects of human cerebral small vessel disease (CSVD). To decipher and understand the underlying disease dynamics, assessment of the temporal pro
Externí odkaz:
https://doaj.org/article/c75e0ce9ae514406b9dc62b33ea64d93
Autor:
Jason V Evans, Shankar Suman, Mounika Uttam L Goruganthu, Elena E Tchekneva, Shuxiao Guan, Rajeswara Rao Arasada, Anneliese Antonucci, Longzhu Piao, Irina Ilgisonis, Andrey A Bobko, Benoit Driesschaert, Roman V Uzhachenko, Rebecca Hoyd, Alexandre Samouilov, Joseph Amann, Ruohan Wu, Lai Wei, Aaditya Pallerla, Sergey V Ryzhov, Igor Feoktistov, Kyungho P Park, Takefumi Kikuchi, Julio Castro, Alla V Ivanova, Thanigaivelan Kanagasabai, Dwight H Owen, Daniel J Spakowicz, Jay L Zweier, David P Carbone, Sergey V Novitskiy, Valery V Khramtsov, Anil Shanker, Mikhail M Dikov
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Background We investigated the role of A2B-adenosine receptor (A2BAR) in regulating immunosuppressive metabolic stress in the tumor microenvironment (TME). Novel A2BAR antagonist PBF-1129 was tested for anti-tumor activity in animals and evaluated fo
Autor:
Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensit
Externí odkaz:
https://doaj.org/article/7c48b88ebe1f45628a4d604983c1bc11
Publikováno v:
Stroke. 54
Introduction: CD38 enzymatic activity is the main determinant of the age-dependent decline in nicotinamide adenine dinucleotide (NAD + ) levels and the loss of CD38 function has been associated with increased longevity in rodents. Therefore, we hypot
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 96-104 (2016)
In humans, sulfite is generated endogenously by the metabolism of sulfur containing amino acids such as methionine and cysteine. Sulfite is also formed from exposure to sulfur dioxide, one of the major environmental pollutants. Sulfite is used as an
Externí odkaz:
https://doaj.org/article/09c8347e3c8041cd90d32ad4b6cc5b7c
Autor:
Yalan Feng, Xiaoli Tan, Zhaojun Shi, Frederick A. Villamena, Jay L. Zweier, Yuguang Song, Yangping Liu
Publikováno v:
Analytical Chemistry.
Electron paramagnetic resonance (EPR) spectroscopy and imaging coupled with the use of suitable probes is a promising tool for assessment of the tumor microenvironment (TME). Measurement of multiple TME parameters by EPR is very desirable but challen
Publikováno v:
Applied Magnetic Resonance. 53:233-246
Autor:
Saradhadevi Varadharaj, Owen J. Kelly, Rami N. Khayat, Purnima S. Kumar, Naseer Ahmed, Jay L. Zweier
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 4 (2017)
In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eN
Externí odkaz:
https://doaj.org/article/61496ceda7184cc7b329df99a6bfbcab
Publikováno v:
Magn Reson Med
PURPOSE To develop a novel resonator for high-quality fast scan electron paramagnetic resonance (EPR) and EPR/NMR co-imaging of the head and brain of mice at 1.25 GHz. METHODS Resonator dimensions were scaled to fit the mouse head with maximum fillin