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The Hepatitis C Care Cascade During the Direct-Acting Antiviral Era in a United States Commercially Insured Population

Autor: Nicole D Ferrante, Craig W Newcomb, Kimberly A Forde, Charles E Leonard, Jessie Torgersen, Benjamin P Linas, Sarah E Rowan, David L Wyles, Jay Kostman, Stacey B Trooskin, Vincent Lo Re

Publikováno v: Open forum infectious diseases. 9(9)

Background Periodic surveillance of the hepatitis C virus (HCV) care cascade is important for tracking progress toward HCV elimination goals, identifying gaps in care, and prioritizing resource allocation. In the pre-direct-acting antiviral (DAA) era

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e600078face79fd23feee164b13f471
https://pubmed.ncbi.nlm.nih.gov/36092829

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Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

Autor: Leila Giron, Clovis Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas, Mohammad Damra, Aaron Goldman, Hsin-Yao Tang, Rowena Johnston, Karam Mounzer Mounzer, Jay Kostman, Pablo Tebas, Alan Landay, Luis Montaner, Jeffrey Jacobson, Jonathan Li, Mohamed Abdel-Mohsen

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c0dd9c39d043f0b19f271de2ce2f89
https://doi.org/10.21203/rs.3.rs-132507/v1

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Retinoblastoma protein induction by HIV viremia or CCR5 in monocytes exposed to HIV-1 mediates protection from activation-induced apoptosis: ex vivo and in vitro study

Autor: Bethsebah Gekonge, Karam Mounzer, Luis J. Montaner, Louise C. Showe, Jay Kostman, Ronald G. Collman, Andrea D. Raymond, Xiangfan Yin

Publikováno v: Journal of Leukocyte Biology. 92:397-405

Identification of Rb1 induction in chronic asymptomatic HIV-1 infection as a mediator of apoptosis resistance in monocytes, in association with protective autophagy. We have previously described an antiapoptotic steady-state gene expression profile i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da334dd8354d119718913921187b31a1
https://doi.org/10.1189/jlb.1111552

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Pain and Physical and Psychological Symptoms in Ambulatory HIV Patients in the Current Treatment Era

Autor: Aura Obando, Craig Alpert, Liyi Cen, Sophie Woolston, Amy Praestgaard, Robert Gross, Jessica S. Merlin, Michelle Turner, David Casarett, Ian Frank, Jay Kostman

Publikováno v: Journal of Pain and Symptom Management. 43:638-645

HIV infection has become a manageable chronic disease. There are few studies of pain and symptoms in the current treatment era.Our primary objective was to determine the prevalence of and risk factors for pain and physical and psychological symptoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a6003d08aa5fdf82a5624b69b09138
https://doi.org/10.1016/j.jpainsymman.2011.04.019

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Inability of Plasmacytoid Dendritic Cells To Directly Lyse HIV-Infected Autologous CD4 + T Cells despite Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Autor: Kavita Vinekar, Costin Tomescu, Maxwell Pistilli, Jihed Chehimi, Shaheed A. Abdulhaqq, Griffin Reynolds, Aidan Hancock, Craig Carty, Emmanouil Papasavvas, Andrea D. Raymond, Karam Mounzer, Luis J. Montaner, Jay Kostman, Bethsebah Gekonge

Publikováno v: Journal of Virology. 84:2762-2773

The function of plasmacytoid dendritic cells (PDC) in chronic human immunodeficiency virus type 1 (HIV-1) infection remains controversial with regard to its potential for sustained alpha interferon (IFN-α) production and induction of PDC-dependent t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad179b69050076e12095cbeb8d694c7
https://doi.org/10.1128/jvi.01350-09

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Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance

Autor: Andrea D. Raymond, Shenoa Creer, Bethsebah Gekonge, Ronald G. Collman, Malavika S. Giri, Jane Shull, Louise C. Showe, Karam Mounzer, Aidan Hancock, Calen Nicols, Guido Silvestri, Luis J. Montaner, Malik Yousef, Jay Kostman, Michael Nebozyhn, Andrea S. Foulkes

Publikováno v: The Journal of Immunology. 182:4459-4470

Mechanisms that may allow circulating monocytes to persist as CD4 T cells diminish in HIV-1 infection have not been investigated. We have characterized steady-state gene expression signatures in circulating monocytes from HIV-infected subjects and ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35388c067a989bcca7fcc9dab34122d3
https://doi.org/10.4049/jimmunol.0801450

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Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia

Autor: Calen Nicols, Jay Kostman, Jane Shull, Louise C. Showe, Bethsebah Gekonge, Emmanouil Papasavvas, Andrew V. Kossevkov, Andrea D. Raymond, Malik Yousef, Aidan Hancock, Malavika S. Giri, Karam Mounzer, Jihed Chehimi, Luis J. Montaner

Publikováno v: Journal of leukocyte biology. 88(3)

Differential expression of metallothionein genes and high intracellular zinc promote monocyte survival during HIV infection. Circulating monocytes exhibit an apoptotic resistance phenotype during HIV viremia in association with increased MT expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5927eb0447c4659f32a98ca0bf40216b
https://pubmed.ncbi.nlm.nih.gov/20551211

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