P1228: GENOME-WIDE CRISPR-CAS9 SCREENING IDENTIFIES THERAPEUTIC TARGETS FOR MATURE T-CELL MALIGNANCIES

Autor: Sanna Timonen, Vanessa Rebecca Gasparini, Ella Piekkari, Olli Dufva, Shady Awad, Yevhen Akimov, Jana von Jan, Till Braun, Aleksandr Ianevski, Matti Kankainen, Jay Klievink, Marco Herling, Tero Aittokallio, Satu Mustjoki

Publikováno v: HemaSphere, Vol 7, p e0412416 (2023)

Externí odkaz: https://doaj.org/article/9484c3ef8db5473d9347097be160c21a

IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia

Autor: Jani Huuhtanen, Mette Ilander, Bhagwan Yadav, Olli M.J. Dufva, Hanna Lähteenmäki, Tiina Kasanen, Jay Klievink, Ulla Olsson-Strömberg, Jesper Stentoft, Johan Richter, Perttu Koskenvesa, Martin Höglund, Stina Söderlund, Arta Dreimane, Kimmo Porkka, Tobias Gedde-Dahl, Björn T. Gjertsen, Leif Stenke, Kristina Myhr-Eriksson, Berit Markevärn, Anna Lübking, Andreja Dimitrijevic, Lene Udby, Ole Weis Bjerrum, Henrik Hjorth-Hansen, Satu Mustjoki

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)

In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising candidate, as it has long-las

Externí odkaz: https://doaj.org/article/41296f647a1141389dad7968d6690e57

Loss-of-function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly.

Autor: Huang Y; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA., Jay KL; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX., Yen-Wen Huang A; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA., Wan J; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA., Jangam SV; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX., Chorin O; Institute for Rare Diseases, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel., Rothschild A; Institute for Rare Diseases, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel., Barel O; Genomics Unit, The Center for Cancer Research, Sheba Medical Center, Tel HaShomer, Israel; Sheba Medical Center, Wohl Institute of Translational Medicine, Ramat Gan, Israel., Mariani M; Pediatric Department, ASST Lariana, Santa Anna General Hospital, Italy., Iascone M; Laboratorio di Genetica Medica, ASST Papa Giovanni XXIII, Bergamo, Italy., Xue H; Shanghai Institute of Precision Medicine at Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Huang J; Shanghai Institute of Precision Medicine at Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Mignot C; AP-HP Sorbonne Université, Département de Génétique, France; Centre de Référence Déficiences Intellectuelles de Causes Rares, France., Keren B; Genetic Department, GCS SeqOIA, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France., Saillour V; Laboratoire de biologie médicale multisites Seqoia - FMG2025, Paris, France., Mah-Som AY; Harvard Medical School Genetics Training Program, Boston, MA., Sacharow S; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA., Rajabi F; Section of Clinical Genetics and Metabolism, Department of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO., Costin C; Division of Medical Genetics, Akron Children's Hospital, Akron, OH., Yamamoto S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX., Kanca O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX., Bellen HJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX., Rosenfeld JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Baylor Genetics Laboratories, Houston, TX., Palmer CGS; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA., Nelson SF; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA., Wangler MF; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston TX. Electronic address: michael.wangler@bcm.edu., Martinez-Agosto JA; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: julianmartinez@mednet.ucla.edu.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2024 Nov; Vol. 26 (11), pp. 101218. Date of Electronic Publication: 2024 Jul 19.

A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins.

Autor: Guichard A; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA., Lu S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Kanca O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Bressan D; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA; Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Huang Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Ma M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Sanz Juste S; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA; Department of Epigenetics & Molecular Carcinogenesis at MD Anderson, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX, USA., Andrews JC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Jay KL; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Sneider M; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA., Schwartz R; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA., Huang MC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Bei D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Pan H; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Ma L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Lin WW; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Auradkar A; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA., Bhagwat P; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Park S; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Wan KH; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Ohsako T; Advanced Technology Center, Kyoto Institute of Technology, Kyoto 606-8585, Japan., Takano-Shimizu T; Kyoto Drosophila Stock Center and Faculty of Applied Biology, Kyoto Institute of Technology, Kyoto 616-8354, Japan., Celniker SE; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Wangler MF; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA., Yamamoto S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Development, Disease Models & Therapeutics Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: yamamoto@bcm.edu., Bellen HJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hbellen@bcm.edu., Bier E; Section of Cell and Developmental Biology, University of California, San Diego (UCSD), La Jolla, CA 92093, USA; Tata Institute for Genetics and Society - UCSD, La Jolla, CA 92093, USA. Electronic address: ebier@ucsd.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112842. Date of Electronic Publication: 2023 Jul 20.

A child's garden of curses: a gender, historical, and age-related evaluation of the taboo lexicon.

Autor: Jay KL; Psychology Department, Marist College, Poughkeepsie, NY 12601, USA. Kristin.Jay@marist.edu, Jay TB; Massachusetts College of Liberal Arts, USA.

Publikováno v: The American journal of psychology [Am J Psychol] 2013 Winter; Vol. 126 (4), pp. 459-75.