Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jay K Trautman"'
Autor:
Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e128 (2005)
We have implemented an unbiased cell morphology-based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system. This assay format provides unbiased analysis of morphological ef
Externí odkaz:
https://doaj.org/article/793028f6ead843649a23bfd14fe7747d
Autor:
Jay K. Trautman, X. Sunney Xie
Publikováno v:
Annual Review of Physical Chemistry. 49:441-480
▪ Abstract Recent developments in optical studies of single molecules at room temperature are reviewed, with an emphasis on the underlying principles and the potential of single-molecule experiments. Examples of single-molecule studies are given, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb1ef3b6cd0c9b2d564cbf26113779a
https://doi.org/10.1146/annurev.physchem.49.1.441
https://doi.org/10.1146/annurev.physchem.49.1.441
Publikováno v:
Science. 272:255-258
Far-field microscopy was used to noninvasively measure the room-temperature optical properties of single dye molecules located on a polymer-air interface. Shifts in the fluorescence spectrum, due to perturbation by the locally varying molecular envir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b748c4e116c6d64ecab0144601a3f24c
https://doi.org/10.1126/science.272.5259.255
https://doi.org/10.1126/science.272.5259.255
Publikováno v:
Review of Scientific Instruments. 65:626-631
The design and implementation of a low temperature (T≥1.5 K), near‐field scanning optical microscope are described herein. This microscope, which is based on the recently developed tapered fiber probe, is optimized for luminescence imaging and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8690b7ebf73f8727b1dc22054f8cae35
https://doi.org/10.1063/1.1145128
https://doi.org/10.1063/1.1145128
Publikováno v:
Applied Spectroscopy. 48:14A-21A
Among the remaining challenges facing chemical analysis is the capability of extending to micro-scale samples the spectacular detection limits that have been achieved for a variety of spectroscopic methods. In such samples, a vanishingly small quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3958e636bcc04121f1202087cef18895
https://doi.org/10.1366/0003702944027589
https://doi.org/10.1366/0003702944027589
Publikováno v:
Applied optics. 31(22)
Recent advances in probe design have led to enhanced resolution (currently as significant as ~ 12 nm) in optical microscopes based on near-field imaging. We demonstrate that the polarization of emitted and detected light in such microscopes can be ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fee7f3f7346931303b03c7aeb772b8
https://pubmed.ncbi.nlm.nih.gov/20725460
https://pubmed.ncbi.nlm.nih.gov/20725460
Autor:
Eric Betzig, Jay K. Trautman
Publikováno v:
Science. 257:189-195
The near-field optical interaction between a sharp probe and a sample of interest can be exploited to image, spectroscopically probe, or modify surfaces at a resolution (down to approximately 12 nm) inaccessible by traditional far-field techniques. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5904ae148afa3ac76e6a433d48cc6346
https://doi.org/10.1126/science.257.5067.189
https://doi.org/10.1126/science.257.5067.189
Autor:
Jay K. Trautman, Frances Hellman, Eric Betzig, Timothy D. Harris, E. M. Gyorgy, J. S. Weiner, David J. DiGiovanni
Publikováno v:
Journal of Applied Physics. 71:4659-4663
The resolution of optical microscopy can be extended beyond the diffraction limit by placing a source or detector of visible light having dimensions much smaller than the wavelength, λ, in the near‐field of the sample (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e0a8ca82ea9f3880e8dcbe7d2bda69
https://doi.org/10.1063/1.350655
https://doi.org/10.1063/1.350655
Autor:
Cynthia L, Adams, Vadim, Kutsyy, Daniel A, Coleman, Ge, Cong, Anne Moon, Crompton, Kathleen A, Elias, Donald R, Oestreicher, Jay K, Trautman, Eugeni, Vaisberg
Publikováno v:
Methods in enzymology. 414
Compounds with similar target specificities and modes of inhibition cause similar cellular phenotypes. Based on this observation, we hypothesized that we could quantitatively classify compounds with diverse mechanisms of action using cellular phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eabc13c78e8520fced990475ea434b48
https://pubmed.ncbi.nlm.nih.gov/17110206
https://pubmed.ncbi.nlm.nih.gov/17110206
Publikováno v:
Nature. 369:40-42
THE ability to observe the optical spectrum of a single molecule can afford insights into the interactions that distinguish one molecular environment from another. Such sensitivity has recently been achieved at liquid-helium temperatures1–5. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e1a849110e738a329cb2bfebb331ee
https://doi.org/10.1038/369040a0
https://doi.org/10.1038/369040a0