Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jay Jayakumar"'
Autor:
Raghavan Jay Jayakumar
Publikováno v:
Fusion Science and Technology. 46:225-233
Achieving high performance for long duration is a key goal of advanced tokamak research around the world. To this end, tokamak experiments are focusing on obtaining (a) a high fraction of well-aligned noninductive plasma current, (b) internal transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bbf4b445273d8085669ac73ecb572f4
https://doi.org/10.13182/fst04-a559
https://doi.org/10.13182/fst04-a559
Autor:
Jay Jayakumar, Andrew T. Goodwin, Magdi H. Yacoub, Caroline C. Gray, Adrian Marchbank, Mohamed Amrani
Publikováno v:
Clinical Science. 103:189S-193S
Endothelin (ET) may have both detrimental (reduced coronary flow) and beneficial effects (positive inotrope, reduced arrhythmogenesis) following ischaemia. We examined the effects of ET on cardiac function during reperfusion following prolonged hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdb7a1ef62d85cf83925d8f166a7192
https://doi.org/10.1042/cs103s189s
https://doi.org/10.1042/cs103s189s
Autor:
Magdi H. Yacoub, Jay Jayakumar, Caroline C. Gray, Mohamed Amrani, Andrew T. Goodwin, Ryszard T. Smolenski
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 122(6):1167-1173
Objective: Endothelin plays a role in the regulation of basal coronary tone. We hypothesized that low coronary reflow and reduced cardiac function after prolonged ischemia may be due to increased release of endogenous endothelin. Methods: Using an is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584266a170d46e1b8e9fb749f368a306
Autor:
Caroline C. Gray, Adrian Marchbank, Jay Jayakumar, Andrew T. Goodwin, Magdi H. Yacoub, Mohamed Amrani
Publikováno v:
Cardiovascular Research. 41:554-562
Ageing is known to be associated with changes within the heart. We investigated whether the coronary response to endothelin-1 (ET) and sarafotoxin S6c (S6c) is altered with increasing age, before and after cardioplegic arrest.Using an isolated rat he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d927df1ef2b3e5318b538234d69c51
https://doi.org/10.1016/s0008-6363(98)00253-3
https://doi.org/10.1016/s0008-6363(98)00253-3
Publikováno v:
The Journal of Physiology. 511:549-557
1. Coronary vascular tone is a vital factor that regulates the delivery of oxygen to cardiac muscle. We tested the hypothesis that basal coronary tone may depend on the release of an endogenous vasoconstrictor peptide, endothelin (ET). 2. Using an is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7600bbb6a7348d7aed60981616bd938
https://doi.org/10.1111/j.1469-7793.1998.549bh.x
https://doi.org/10.1111/j.1469-7793.1998.549bh.x
Autor:
Magdi H. Yacoub, Kameljit K. Kalsi, Jay Jayakumar, Andrew T. Goodwin, Ryszard T. Smolenski, Mohamed Amrani, Caroline C. Gray
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 13:467-474
Objecti6e: Heat stress and induction of heat shock proteins confer protection against myocardial ischemia-reperfusion injury; however the precise mechanisms of this effect remain unknown. We investigated the influence of heat stress on metabolic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c5e589b65ce8799e142b4c939d30c4a
https://doi.org/10.1016/s1010-7940(98)00031-1
https://doi.org/10.1016/s1010-7940(98)00031-1
Autor:
Simon Ledingham, Mohamed Amrani, Steven Rothery, Magdi H. Yacoub, Nicholas J. Severs, Osamu Katayama, Ryszard T. Smolenski, Jay Jayakumar
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 11:751-762
Objective: Monitoring of cardioplegia infusion pressure may be important, particularly in immature hearts and in hearts without coronary artery disease. We have investigated the effects of infusion pressure on the preservation of the isolated rat hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8018f65be470ef4dd0bb6074ba642494
https://doi.org/10.1016/s1010-7940(96)01134-7
https://doi.org/10.1016/s1010-7940(96)01134-7
Functional and Metabolic Effects of Adenosine in Cardioplegia: Role of Temperature and Concentration
Autor:
Mohamed Amrani, David R. Lachno, Jay Jayakumar, Ryszard T. Smolenski, Osamu Katayama, Frcs Magdi H Yacoub, Simon Ledingham
Publikováno v:
The Annals of Thoracic Surgery. 63:449-454
Addition of adenosine to cardioplegic fluid has been shown to improve myocardial tolerance to ischemia. This study was designed to investigate further this phenomenon to evaluate the dose-response and the temperature dependence of the effect of addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf3809297ea818b0491dc6007090c1a
https://doi.org/10.1016/s0003-4975(96)01230-1
https://doi.org/10.1016/s0003-4975(96)01230-1
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 111(1):238-245
The aging process is known to be associated with profound changes in the heart. To determine whether resistance of coronary endothelial and vascular smooth muscle function to ischemia may be related to age, four groups of rats ( n = 6 in each group)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55be96329f0baa5c64296cd61864b45
Publikováno v:
Cardiovascular Research. 30:200-204
Objective: To evaluate the effect of l-arginine, the physiological substrate of nitric oxide (NO), upon coronary flow (CF) and mechanical function during reperfusion following cardioplegic arrest. Methods: Two groups of isolated rat hearts were subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a764fabfd5774de83afc2df53795b48c
https://doi.org/10.1016/s0008-6363(95)00021-6
https://doi.org/10.1016/s0008-6363(95)00021-6