Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jay I. Koepke"'
Autor:
Gheorghe Proteasa, Bradley C. Logsdon, Jay I. Koepke, Stanley R. Terlecky, Thomas C. Merigan, Mark A. Winters, Ladislau C. Kovari, Philip D. Martin, Zdzislaw Wawrzak, John F. Vickrey
Publikováno v:
Journal of Virology. 78:3123-3132
The goal of this study was to use X-ray crystallography to investigate the structural basis of resistance to human immunodeficiency virus type 1 (HIV-1) protease inhibitors. We overexpressed, purified, and crystallized a multidrug-resistant (MDR) HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170875d6e2ab5205f637234d68e62d3c
https://doi.org/10.1128/jvi.78.6.3123-3132.2004
https://doi.org/10.1128/jvi.78.6.3123-3132.2004
Publikováno v:
Nucleic Acids Research. 28:4460-4466
The Ino4 protein belongs to the basic helix–loop–helix (bHLH) family of proteins. It is known to form a dimer with Ino2p, which regulates phospholipid biosynthetic genes. Mammalian bHLH proteins have been shown to form multiple dimer combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83407cb66bb9bfeaff47c618fa1b5f94
https://doi.org/10.1093/nar/28.22.4460
https://doi.org/10.1093/nar/28.22.4460
Autor:
Savoy L. Boyd, Chen N. Young, Jay I. Koepke, Laura J. Terlecky, Michael S. Borkin, Stanley R. Terlecky
The multifunctional cytokine tumor necrosis factor-alpha (TNF-alpha) is known to play an important role in inflammatory and immunological responses in human skin. Although it has been documented that reactive oxygen species (ROS) are involved in TNF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af23e671873ba1671a9d6bbd808f1e0
https://europepmc.org/articles/PMC4102307/
https://europepmc.org/articles/PMC4102307/
Publikováno v:
Toxicology and applied pharmacology. 232(1)
Peroxisomes generate hydrogen peroxide, a reactive oxygen species, as part of their normal metabolism. A number of pathological situations exist in which the organelle's capacity to degrade the potentially toxic oxidant is compromised. It is the pero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c7801f541225363be9f21b0922b060
https://pubmed.ncbi.nlm.nih.gov/18634817
https://pubmed.ncbi.nlm.nih.gov/18634817
Autor:
Jay I. Koepke, Paul A. Walton, Krissy K. Boucher, Christopher S. Wood, Laura J. Terlecky, Stanley R. Terlecky, Kerry Ann Nakrieko
Publikováno v:
Traffic (Copenhagen, Denmark). 8(11)
Peroxisomes play an important role in human cellular metabolism by housing enzymes involved in a number of essential biochemical pathways. Many of these enzymes are oxidases that transfer hydrogen atoms to molecular oxygen forming hydrogen peroxide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29fa5efe5c29ec48cfd0c361995ea2f
https://pubmed.ncbi.nlm.nih.gov/17822396
https://pubmed.ncbi.nlm.nih.gov/17822396
Drug delivery to peroxisomes: employing unique trafficking mechanisms to target protein therapeutics
Autor:
Jay I. Koepke, Stanley R. Terlecky
Publikováno v:
Advanced drug delivery reviews. 59(8)
Peroxisomes are multifunctional organelles of all human cells, responsible for a variety of essential biochemical and metabolic processes including alpha- and beta-oxidation of specific fatty acids, plasmalogen biosynthesis and glyoxylate detoxificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e339b58566f206ba68601683f4d735e
https://pubmed.ncbi.nlm.nih.gov/17659806
https://pubmed.ncbi.nlm.nih.gov/17659806
Peroxisomes are indispensable for proper functioning of human cells. They efficiently compartmentalize enzymes responsible for a number of metabolic processes, including the absolutely essential β-oxidation of specific fatty acid chains. These and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29668b7ee38e44b3ce91fe47d2d4d262
https://europepmc.org/articles/PMC2997701/
https://europepmc.org/articles/PMC2997701/
Autor:
Christopher S, Wood, Jay I, Koepke, Hua, Teng, Krissy K, Boucher, Sharon, Katz, Patrick, Chang, Laura J, Terlecky, Irene, Papanayotou, Paul A, Walton, Stanley R, Terlecky
Publikováno v:
Traffic (Copenhagen, Denmark). 7(1)
Human epidemiological studies point to an association of hypocatalasemia and an increased risk of age-related disease. Unfortunately, the cellular and molecular manifestations of hypocatalasemia are only poorly understood. In this analysis, we have e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afd8c3f6ce554a105a20b1c73cfa025b
https://pubmed.ncbi.nlm.nih.gov/16445690
https://pubmed.ncbi.nlm.nih.gov/16445690
Autor:
Ferdous Barlaskar, Jay I. Koepke, Laura J. Terlecky, Stanley R. Terlecky, Julie E. Legakis, Holly Edwards, Christopher Jedeszko, Paul A. Walton
Publikováno v:
Molecular biology of the cell. 13(12)
The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. In this report, we characterize age-related changes in peroxisomes of human cells. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc23bad5b1fbdfbefb4202004fa7a72
https://pubmed.ncbi.nlm.nih.gov/12475949
https://pubmed.ncbi.nlm.nih.gov/12475949