Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jay H Konieczka"'
Autor:
Dawn A Thompson, Sushmita Roy, Michelle Chan, Mark P Styczynski, Jenna Pfiffner, Courtney French, Amanda Socha, Anne Thielke, Sara Napolitano, Paul Muller, Manolis Kellis, Jay H Konieczka, Ilan Wapinski, Aviv Regev
Publikováno v:
eLife, Vol 2 (2013)
Externí odkaz:
https://doaj.org/article/6af4fc673c904cc0a0ec5bd29202ae3a
Autor:
Dawn A Thompson, Sushmita Roy, Michelle Chan, Mark P Styczynsky, Jenna Pfiffner, Courtney French, Amanda Socha, Anne Thielke, Sara Napolitano, Paul Muller, Manolis Kellis, Jay H Konieczka, Ilan Wapinski, Aviv Regev
Publikováno v:
eLife, Vol 2 (2013)
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along
Externí odkaz:
https://doaj.org/article/6c41a8412cae4405bcabcd5acc8a0273
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18077 (2011)
Efficient and precise genome manipulations can be achieved by the Flp/FRT system of site-specific DNA recombination. Applications of this system are limited, however, to cases when target sites for Flp recombinase, FRT sites, are pre-introduced into
Externí odkaz:
https://doaj.org/article/7480bb0f6d874e59a16cc11e9413f295
Autor:
Kristin J. Adolfsen, Isolde Callihan, Catherine E. Monahan, Per Jr. Greisen, James Spoonamore, Munira Momin, Lauren E. Fitch, Mary Joan Castillo, Lindong Weng, Lauren Renaud, Carl J. Weile, Jay H. Konieczka, Teodelinda Mirabella, Andres Abin-Fuentes, Adam G. Lawrence, Vincent M. Isabella
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
PKU patients have elevated phenylalanine levels which can result in neurological impairment. Here the authors utilize biosensor-based ultra-high-throughput screening to optimize PAL activity in a synthetic biotic platform for improved in vivo perform
Externí odkaz:
https://doaj.org/article/026a2581af754d8aa8526f2be41ac1f4
Autor:
Lauren E Fitch, Vincent M. Isabella, Kristin J. Adolfsen, Munira Momin, Teodelinda Mirabella, Adam G Lawrence, James E. Spoonamore, Per Jr Greisen, Andres Abin-Fuentes, Isolde Callihan, Mary Castillo, Lauren Renaud, Carl J Weile, Catherine E Monahan, Lindong Weng, Jay H Konieczka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
In phenylketonuria (PKU) patients, a genetic defect in the enzyme phenylalanine hydroxylase (PAH) leads to elevated systemic phenylalanine (Phe), which can result in severe neurological impairment. As a treatment for PKU, Escherichia coli Nissle (EcN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d852ca494f7c8b8506758e360ce645
https://doaj.org/article/026a2581af754d8aa8526f2be41ac1f4
https://doaj.org/article/026a2581af754d8aa8526f2be41ac1f4
Publikováno v:
Computers & Industrial Engineering. 58:680-690
Network elucidation is the problem of inferring all parameters of a network from a subset of those parameters. We introduce the Network Elucidation Template (NET), which provides a framework upon which algorithms for such problems can be built. NET a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca18e96ddc83ba8ecd6d8ae3348b8497
https://doi.org/10.1016/j.cie.2010.01.013
https://doi.org/10.1016/j.cie.2010.01.013
Autor:
Derrick Broka, Jay H. Konieczka, Parker B. Antin, Scott E. Klewer, Alejandro Lencinas, Todd D. Camenisch, Raymond B. Runyan
Publikováno v:
Toxicological Sciences. 116:273-285
Arsenic is a naturally occurring metalloid and environmental contaminant. Arsenic exposure in drinking water is reported to cause cancer of the liver, kidneys, lung, bladder, and skin as well as birth defects, including neural tube, facial, and vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2543d42dc3fcae4c781d97472928b52
https://doi.org/10.1093/toxsci/kfq086
https://doi.org/10.1093/toxsci/kfq086
Autor:
Simran Kaur, Parker B. Antin, Tatiana A. Yatskievych, Sean Davey, Stacey Stanislaw, Diana K. Darnell, Jay H. Konieczka
Publikováno v:
Poultry Science. 86:1472-1477
With sequencing of the chicken genome largely completed, significant effort is focusing on gene annotation, including acquiring information about the patterns of gene expression. The chicken embryo is ideally suited to provide detailed temporal and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c255c15b1e5ec4e61495a2a4072c3953
https://doi.org/10.1093/ps/86.7.1472
https://doi.org/10.1093/ps/86.7.1472
Autor:
Tatiana A. Yatskievych, Parker B. Antin, Jay H. Konieczka, Stacey Stanislaw, Diana K. Darnell, Sean Davey, Simran Kaur
Publikováno v:
Cytogenetic and Genome Research. 117:30-35
An important and ongoing focus of biomedical and agricultural avian research is to understand gene function, which for a significant fraction of genes remains unknown. A first step is to determine when and where genes are expressed during development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc5a2a29385340b245efb4753289b5d
https://doi.org/10.1159/000103162
https://doi.org/10.1159/000103162
Autor:
Makkuni Jayaram, Jay H. Konieczka, Yuri Voziyanov, Andrew L. Paek, Chien-Hui Ma, Swetha Bolusani
Publikováno v:
Nucleic Acids Research
As a tool in directed genome manipulations, site-specific recombination is a double-edged sword. Exquisite specificity, while highly desirable, makes it imperative that the target site be first inserted at the desired genomic locale before it can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8551fe5413b936fb2e2a27497375a0
https://doi.org/10.1093/nar/gkl548
https://doi.org/10.1093/nar/gkl548