Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jay Gibbons"'
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Purpose: Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e9c231d90692706480e995eac2927b
https://doi.org/10.1158/1078-0432.c.6524297
https://doi.org/10.1158/1078-0432.c.6524297
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 9: Summary of Gene Set Enrichment analysis results performed on expression data upon ALK inhibition in 10 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ba2b9fbd5cfbaa48dbc06a331da43
https://doi.org/10.1158/1078-0432.22459751.v1
https://doi.org/10.1158/1078-0432.22459751.v1
Autor:
Jay Gibbons, Semiramis Ayral-Kaloustian, Osvaldo dos Santos, Zecheng Chen, Efren Delos Santos, Christoph Dehnhardt, Aranapakam Venkatesan, Veronica Soloveva, Judy Lucas, Larry Feldberg, Irwin Hollander, Robert Mallon
Adobe PDF - Supplementary_Data.pdf from Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709b28e2f7bf6d37c791b4af89125c81
https://doi.org/10.1158/1535-7163.22485176
https://doi.org/10.1158/1535-7163.22485176
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 13: Summary of Gene Set Enrichment analysis results obtained on expression profiling data of CLB-Ââ€�GA on different time points (10' - 30'- 60' - 2h - 4h - 6h) after pharmacological inhibition using TAE-Ââ€�684.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25178759ac101de20553303d661c8c67
https://doi.org/10.1158/1078-0432.22459757.v1
https://doi.org/10.1158/1078-0432.22459757.v1
Autor:
Jay Gibbons, Semiramis Ayral-Kaloustian, Osvaldo dos Santos, Zecheng Chen, Efren Delos Santos, Christoph Dehnhardt, Aranapakam Venkatesan, Veronica Soloveva, Judy Lucas, Larry Feldberg, Irwin Hollander, Robert Mallon
PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-α mutants, and mammalian target of rapamycin (mTOR; IC50 versus PI3K-α = 2 nmol/L). PKI-402 inhibited growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f1cc874f1a18d6a1152eb720ccdae
https://doi.org/10.1158/1535-7163.c.6531812
https://doi.org/10.1158/1535-7163.c.6531812
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 1: Cell line information: Summary of the characteristics of cell lines used in this study including origin, tumor type, ALK and MYCN status (wt = wild type, NA = non amplified, A = amplified). Supplemental data 2: GI50 concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3d207cd2c5d9d3ddc79d0dc2c9a918
https://doi.org/10.1158/1078-0432.22459748
https://doi.org/10.1158/1078-0432.22459748
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 5: Differential expression analysis upon ALK inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259ac911c3c0e63378435357663b5dc6
https://doi.org/10.1158/1078-0432.22459754.v1
https://doi.org/10.1158/1078-0432.22459754.v1
Autor:
Ker Yu, Tarek S. Mansour, Judy Lucas, Aranapakam Mudumbai Venkatesan, Efren Guillermo Delos Santos, Matthew Gregory Bursavich, Osvaldo Dos Santos, Adam M. Gilbert, Semiramis Ayral-Kaloustian, Zecheng Chen, John W. Ellingboe, Larry Feldberg, Christoph Martin Dehnhardt, Jay Gibbons, Gulnaz Khafizova, Robert T. Abraham, Natasja Brooijmans, Irwin Hollander, Robert Mallon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:653-656
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7271065fafcaf67af5b39a4ea4358a8
https://doi.org/10.1016/j.bmcl.2009.11.057
https://doi.org/10.1016/j.bmcl.2009.11.057
Autor:
Robert Mallon, Semiramis Ayral-Kaloustian, Irwin Hollander, Zecheng Chen, Judy Lucas, Aranapakam Mudumbai Venkatesan, Tarek S. Mansour, Christoph Martin Dehnhardt, Ker Yu, Natasja Brooijmans, Efren Guillermo Delos Santos, Inder Chaudhary, Jay Gibbons, Osvaldo Dos Santos, Larry Feldberg, Robert T. Abraham
Publikováno v:
Journal of Medicinal Chemistry. 53:798-810
Herein we describe the identification and lead optimization of triazolopyrimidines as a novel class of potent dual PI3K/mTOR inhibitors, resulting in the discovery of 3 (PKI-402). Compound 3 exhibits good physical properties and PK parameters, low na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d276d951cd1ddfc627844bd76e54113a
https://doi.org/10.1021/jm9014982
https://doi.org/10.1021/jm9014982
Autor:
Yi Zhu, Martin Hegen, Qin Wang, Jeremy I. Levin, Guixian Jin, Jay Gibbons, Xuemei Du, Lih-Ling Lin, James C. Keith, Rebecca Cowling, LinHong Sun, Terri Cummons, Yuhua Zhang, Jun Xu, Barbara J. Sheppard, J.S. Skotnicki, Cheryl Nickerson-Nutter, Weixin Xu, Vikram R. Rao
Publikováno v:
International Immunopharmacology. 4:1845-1857
TNF-alpha converting enzyme (TACE) is a validated therapeutic target for the development of oral tumor necrosis factor-alpha (TNF-alpha) inhibitors. Here we report the pre-clinical results and characterization of a selective and potent TACE inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8691e7118874ae5ef15857cee8889d8e
https://doi.org/10.1016/j.intimp.2004.08.003
https://doi.org/10.1016/j.intimp.2004.08.003