Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jay George"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123312 (2015)
Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do not reflect the complex extracellular matrix, chemical, and cellular microenvironment of the
Externí odkaz:
https://doaj.org/article/55f7a83ab69040f4972fa455d8dc9b8a
Autor:
Jay, George
Publikováno v:
National Journal of Education, 1877 Jul 01. 6(3), 25-26.
Externí odkaz:
https://www.jstor.org/stable/44958291
Publikováno v:
Angiogenesis. 12:267-274
It has been more than 20 years since it was first demonstrated that endothelial cells will rapidly form capillary-like structures in vitro when plated on top of a reconstituted basement membrane extracellular matrix (BME, Matrigel, EHS matrix, etc.).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb1d904b770cc439cf43d86d9a8b43
https://doi.org/10.1007/s10456-009-9146-4
https://doi.org/10.1007/s10456-009-9146-4
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123312 (2015)
PLoS ONE
PLoS ONE
Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do not reflect the complex extracellular matrix, chemical, and cellular microenvironment of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d5576ab6b769b6bf00f98c0f0e786f
http://europepmc.org/articles/PMC4391795?pdf=render
http://europepmc.org/articles/PMC4391795?pdf=render
Autor:
Kyoichi A. Watanabe, Dorothy Conklin, Alexander Khorlin, Jay George, Wu-Yun Ren, David Brown, Krystyna Lesiak, Michael M. Seidman
Publikováno v:
Journal of Investigative Dermatology. 110:428-437
We have found that several aliphatic and alicyclic diols induce melanogenesis in cultured S91 mouse melanoma cells and normal human epidermal melanocytes (NHEM). In addition, these compounds induce melanogenesis when applied to guinea pig skin, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5f30047db53fe02d8063c56c343747
https://doi.org/10.1046/j.1523-1747.1998.00160.x
https://doi.org/10.1046/j.1523-1747.1998.00160.x
Publikováno v:
The Journal of Organic Chemistry. 63:1906-1909
2-(4-Nitrophenyl)ethyl methylenebis(phosphonate) (6) was prepared by reaction of equimolar amounts of 2-(4-nitrophenyl)ethyl alcohol and methylenebis(phosphonyl) tetrachloride in the presence of tetrazole. Compound 6 was further converted into the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98968004ffc90a002bffc979b6d26528
https://doi.org/10.1021/jo971859a
https://doi.org/10.1021/jo971859a
Publikováno v:
Nucleic Acids Research. 25:1930-1934
3-Nitropyrrole (M) was introduced as a non-discriminating 'universal' base in nucleic acid duplexes by virtue of small size and a presumed tendency to stack but not hydrogen bond with canonical bases. However, the absence of thermally-induced hyperch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5d6a77345c657feaf1f453f194b01d
https://doi.org/10.1093/nar/25.10.1930
https://doi.org/10.1093/nar/25.10.1930
Publikováno v:
Advanced drug delivery reviews.
The basement membrane is an important extracellular matrix that is found in all epithelial and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to molecules, separates different tissue types, transduces mechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c4543e41b48797a4ef2669e2309cd1
https://pubmed.ncbi.nlm.nih.gov/24997339
https://pubmed.ncbi.nlm.nih.gov/24997339
Publikováno v:
Cancer Research. 76:4274-4274
Currently, extracellular matrix hydrogels derived from the Engelbreth-Holmes-Swarm murine tumor (Cultrex BME, Matrigel) are used for stem cell maintenance and differentiation of both normal and tumor organoid culture models. While this matrix is suit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8f436949c5a490053fdb12fecfc729
https://doi.org/10.1158/1538-7445.am2016-4274
https://doi.org/10.1158/1538-7445.am2016-4274
Publikováno v:
Cancer Research. 76:3600-3600
The mechanism of action of many classes of chemotherapeutic agents involves either the repression of DNA repair or an increase in DNA damage. However the measurement of DNA damage levels within a cell has been notoriously difficult and current method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1835996edf524a9b66378b513e8d64bb
https://doi.org/10.1158/1538-7445.am2016-3600
https://doi.org/10.1158/1538-7445.am2016-3600