Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jay G. Forsythe"'
Autor:
Thomas D. Campbell, Rio Febrian, Jack T. McCarthy, Holly E. Kleinschmidt, Jay G. Forsythe, Paul J. Bracher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Wet–dry cycling is regarded as a possible driving force of condensation reactions under prebiotic conditions. Here, the authors propose that water uptake by deliquescent minerals could have facilitated the wet phase and simulate this scenario using
Externí odkaz:
https://doaj.org/article/433ffe88753d4667b27ac33067272f45
Autor:
Moran Frenkel-Pinter, Kaitlin C. Jacobson, Jonathan Eskew-Martin, Jay G. Forsythe, Martha A. Grover, Loren Dean Williams, Nicholas V. Hud
Publikováno v:
Life, Vol 12, Iss 2, p 265 (2022)
The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids. It is likely that the prebiotic forerunners of proteins, or protopeptid
Externí odkaz:
https://doaj.org/article/b72948f0feba4f9bbc863250f99e04f8
Publikováno v:
ACS Earth and Space Chemistry. 4:1349-1359
The amino acid proline plays critical roles in polypeptide structure and function. However, the influence of proline residues on proto-peptide evolution is unknown. In order to begin exploring this...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da07eb5cfa3746746f3d416a2d133527
https://doi.org/10.1021/acsearthspacechem.0c00119
https://doi.org/10.1021/acsearthspacechem.0c00119
Autor:
Jay G. Forsythe, Anyin Li, Marcos Bouza, Anton S. Petrov, Facundo M. Fernández, Zhong Lin Wang
Publikováno v:
Rapid Communications in Mass Spectrometry. 33:1293-1300
RATIONALE Understanding of the molecular processes that led to the first biomolecules on Earth is one of the key aspects of origins-of-life research. Depsipeptides, or polymers with mixed amide and ester backbones, have been proposed as plausible pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be302c274b3ccf08b95c83c3285ed344
https://doi.org/10.1002/rcm.8469
https://doi.org/10.1002/rcm.8469
Autor:
Jody C. May, Tiffany M. Crescentini, Sarah M. Stow, John A. McLean, Jay G. Forsythe, David M. Hercules
Publikováno v:
Analytical Chemistry. 90:14453-14461
Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) is used to characterize methylenedianiline (MDA) 3-ring and 4-ring species. Building on our previous MALDI-MS 2-ring MDA isomer study, here we compare 3-ring and 4-ring electros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f494b3e10e7f8cc6c9da821e902ed4e
https://doi.org/10.1021/acs.analchem.8b04103
https://doi.org/10.1021/acs.analchem.8b04103
Autor:
Jay G. Forsythe, Sloane L. English
Publikováno v:
Rapid Communications in Mass Spectrometry. 32:1507-1513
RATIONALE Depsipeptides, or peptides with a mixture of amide and ester linkages, may have evolved into peptides on primordial Earth. Previous studies on depsipeptides utilized electrospray ionization ion mobility quadrupole time-of-flight (ESI-IM-QTO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15da9f89944e0bbd8d5eb0a1c52a1e9d
https://doi.org/10.1002/rcm.8201
https://doi.org/10.1002/rcm.8201
Autor:
Tiffany M. Crescentini, John A. McLean, Jay G. Forsythe, Sarah M. Stow, David M. Hercules, Jody C. May
Publikováno v:
Analytical Chemistry. 89:9900-9910
Characterization of methylenedianiline (MDA) 2-ring isomers (2,2′-, 2,4′- and 4,4′-MDA) is reported using matrix assisted laser desorption/ionization-mass spectrometry (MALDI-MS), a common technique used for characterizing synthetic polymers. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e7871b057cecb1418f06d15a04011c
https://doi.org/10.1021/acs.analchem.7b02133
https://doi.org/10.1021/acs.analchem.7b02133
Autor:
Holly E. Kleinschmidt, Rio Febrian, Thomas D. Campbell, Jack T. McCarthy, Jay G. Forsythe, Paul J. Bracher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Nature Communications
Nature Communications
Wet–dry cycling is widely regarded as a means of driving condensation reactions under prebiotic conditions to generate mixtures of prospective biopolymers. A criticism of this model is its reliance on unpredictable rehydration events, like rainstor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec733add46a6679c2bb441c9ec5dfa3b
https://doi.org/10.1038/s41467-019-11834-1
https://doi.org/10.1038/s41467-019-11834-1
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 48(2)
A one-pot method was developed for the preparation of a series of β-alanine standards of moderate size (2 to ≥12 residues) for studies concerning the prebiotic origins of peptides. The one-pot synthesis involved two sequential reactions: (1) dry-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb694a458b15d78e1d77cacd11f401e0
https://pubmed.ncbi.nlm.nih.gov/29796877
https://pubmed.ncbi.nlm.nih.gov/29796877