Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jay E. Brenman"'
Autor:
Rob U. Onyenwoke, Jay E. Brenman
Publikováno v:
Journal of Experimental Neuroscience, Vol 2015, Iss Suppl. 2, Pp 81-91 (2016)
Externí odkaz:
https://doaj.org/article/cfca7e20a1c847a5be720f2d37a55d32
Autor:
Rob U. Onyenwoke, Jay E. Brenman
Publikováno v:
Journal of Experimental Neuroscience, Vol 9s2 (2015)
Autophagy is a complex pathway regulated by numerous signaling events that recycles macromolecules and can be perturbed in lysosomal storage diseases (LSDs). The concept of LSDs, which are characterized by aberrant, excessive storage of cellular mate
Externí odkaz:
https://doaj.org/article/7a1a3e05f8d746faa5e1f7c57a4af89c
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1321-1323 (2013)
Summary The maintenance of energetic homeostasis in the face of limited available nutrients is a complex problem faced by all organisms. One important mechanism to maintain energetic homeostasis involves the activation of the energy sensor AMP-activa
Externí odkaz:
https://doaj.org/article/93e768c7ae824be9907a0e617e8cd267
Autor:
Christopher Patrick Laudeman, Lidia S. Nierobisz, Na Young Yi, Jonathan Z. Sexton, Lawrence J. Forsberg, David Lee Musso, Hiral A. Bhagat, Sarah A. Compton, Jay E. Brenman, Kimberly M. P. Jackson
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204605 (2018)
PLoS ONE
PLOS ONE
PLoS ONE
PLOS ONE
Obesity and insulin resistance are primary risk factors for Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD is generally exhibited by non-progressive simple steatosis. However, a significant subset of patient's progress to nonalcoholic steatohepatit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834e165107d91829e89cb332b0727aab
https://doaj.org/article/6351b1f11d1e45c7bf7374679a1fea1a
https://doaj.org/article/6351b1f11d1e45c7bf7374679a1fea1a
Autor:
Na Young Yi, Thomas B. Caligan, Ginger R. Smith, Jonathan Z. Sexton, Jay E. Brenman, Qingping He, Lawrence J. Forsberg
Publikováno v:
ASSAY and Drug Development Technologies. 13:558-569
Diabetes currently affects 9.3% of the U.S. population totaling $245 billion annually in U.S. direct and indirect healthcare costs. Current therapies for diabetes are limited in their ability to control blood glucose and/or enhance insulin sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6906fd45a1fb51801f707b4d8382155
https://doi.org/10.1089/adt.2015.665
https://doi.org/10.1089/adt.2015.665
Autor:
Jonathan Z. Sexton, Michael B. Major, Jay E. Brenman, Rob U. Onyenwoke, Feng Yan, Lawrence J. Forsberg, María Cristina Huertas Díaz
Publikováno v:
Biochemical Journal
The exact mechanisms underlying the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV) are unclear. In the present study, we provide evidence that mTOR regulates the opening and closing of the lysosomal channel responsible for MLIV through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4724645cb58de724eb874a74c1887171
http://europepmc.org/articles/PMC4613499
http://europepmc.org/articles/PMC4613499
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0176502 (2017)
PLoS ONE, Vol 12, Iss 4, p e0176502 (2017)
Carbonic anhydrases are a family of enzymes that catalyze the reversible condensation of water and carbon dioxide to carbonic acid, which spontaneously dissociates to bicarbonate. Carbonic anhydrase III (Car3) is nutritionally regulated at both the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d81c45f6db4a947a285cd274a64f6a9
Publikováno v:
Current Chemical Genomics and Translational Medicine
AMPK is a conserved heterotrimeric serine-threonine kinase that regulates anabolic and catabolic pathways in eukaryotes. Its central role in cellular and whole body metabolism makes AMPK a commonly proposed therapeutic target for illnesses characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f60e77c9f334b8700c995a8fcb2611
https://doi.org/10.2174/2213988501307010030
https://doi.org/10.2174/2213988501307010030
Autor:
Sarah E. Sinnett, Jay E. Brenman
Publikováno v:
Experientia Supplementum ISBN: 9783319435879
In the fruit fly, Drosophila melanogaster, mono-allelic expression of AMPK-α, -β, and -γ yields a single heterotrimeric energy sensor that regulates cellular and whole-body energetic homeostasis. The genetic simplicity of Drosophila, with only a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574e2cc2ba8537d7faf86aa67f71a7fd
https://doi.org/10.1007/978-3-319-43589-3_16
https://doi.org/10.1007/978-3-319-43589-3_16
Publikováno v:
Molecular Biology of the Cell
In this study, we utilized genetic and cell biological approaches to evaluate potential functions for the AMPKα C-terminus. We identify a critical new function for the carboxy-terminal amino acids of AMPKα in vivo, which affects AMPKα subcellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b276aaa52fbfe9791941ef5ee05bc2b
https://doi.org/10.1091/mbc.e10-04-0347
https://doi.org/10.1091/mbc.e10-04-0347