Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jay Dewald"'
Autor:
Ana Lopez-Campistrous, Esther Ekpe Adewuyi, Matthew G.K. Benesch, Yi Man Ko, Raymond Lai, Aducio Thiesen, Jay Dewald, Peng Wang, Karen Chu, Sunita Ghosh, David C. Williams, Larissa J. Vos, David N. Brindley, Todd P.W. McMullen
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 86-97 (2016)
Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dediff
Externí odkaz:
https://doaj.org/article/c5c4da49361e49e0a54a8697243b501a
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 597-606 (2016)
Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival. The lysophosphatidate and S1P signals are terminated partly by d
Externí odkaz:
https://doaj.org/article/9718ddfde9af41a08611268f696fb056
Autor:
Xiaoyun Tang, Matthew G.K. Benesch, Jay Dewald, Yuan Y. Zhao, Neeraj Patwardhan, Webster L. Santos, Jonathan M. Curtis, Todd P.W. McMullen, David N. Brindley
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2389-2400 (2014)
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cell
Externí odkaz:
https://doaj.org/article/2d44e8bac66f4097aa70ac4671a8ac9a
Autor:
Peng Wang, Todd P. W. McMullen, Jay Dewald, Raymond Lai, Karen Chu, Matthew G.K. Benesch, Yi Man Ko, David N. Brindley, Esther Ekpe Adewuyi, Sunita Ghosh, Larissa J. Vos, David Williams, Aducio Thiesen, Ana Lopez-Campistrous
Publikováno v:
EBioMedicine
EBioMedicine, Vol 12, Iss C, Pp 86-97 (2016)
EBioMedicine, Vol 12, Iss C, Pp 86-97 (2016)
Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dediff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397bb2550b262e803b92311244b8f86c
https://doi.org/10.1016/j.ebiom.2016.09.007
https://doi.org/10.1016/j.ebiom.2016.09.007
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 597-606 (2016)
Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival. The lysophosphatidate and S1P signals are terminated partly by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf8b07408a474ded6babf4e13da4ff6
http://www.sciencedirect.com/science/article/pii/S0022227520354158
http://www.sciencedirect.com/science/article/pii/S0022227520354158
Autor:
Yi M. Ko, Yuan Y. Zhao, Jay Dewald, Ana Lopez-Campistrous, Matthew G.K. Benesch, Xiaoyun Tang, Jonathan M. Curtis, Raymond Lai, Todd P. W. McMullen, David N. Brindley
Publikováno v:
Endocrine-Related Cancer. 22:593-607
Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA). In cancers, LPA increases tumour growth, metastasis and chemoresistance by activating six G-protein coupled receptors. We examined >200 hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46db1137bb00c91eb22535c1d6b1ac1b
https://doi.org/10.1530/erc-15-0045
https://doi.org/10.1530/erc-15-0045
Autor:
Zhiwen Yu, Khajag Koulajian, Tony K.T. Lam, Adria Giacca, Roger Gutierrez-Juarez, Andrei I. Oprescu, Sonia M. Najjar, Deling Li, Alexander Ivovic, Jamel El-Benna, Jay Dewald, Laura Stavar, Robert Mckay, Toyoyoshi Uchida, Sandra Pereira, C. Andrew Haber, David N. Brindley, I. George Fantus, Thomas A. Bowman, Sanjay Bhanot, Yusaku Mori, Edward Park, Ping Han
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 307:E34-E46
Fat-induced hepatic insulin resistance plays a key role in the pathogenesis of type 2 diabetes in obese individuals. Although PKC and inflammatory pathways have been implicated in fat-induced hepatic insulin resistance, the sequence of events leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0ca7112f4f59bf76776125769a852c
https://doi.org/10.1152/ajpendo.00436.2013
https://doi.org/10.1152/ajpendo.00436.2013
Autor:
Rodrigo M.P. Siloto, David N. Brindley, Randall J. Weselake, Elzbieta Mietkiewska, Jay Dewald, Saleh Shah
Publikováno v:
FEBS Journal. 278:764-775
The identification of the yeast phosphatidate phosphohydrolase (PAH1) gene encoding an enzyme with phosphatidate phosphatase (PAP; 3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) activity led to the discovery of mammalian Lipins and subsequently to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df70d3bf021f02c73188fb59ba841d1d
https://doi.org/10.1111/j.1742-4658.2010.07995.x
https://doi.org/10.1111/j.1742-4658.2010.07995.x
Autor:
David N. Brindley, Jay Dewald, Todd P. W. McMullen, John R. Mackey, Wei-Feng Dong, Matthew G.K. Benesch, Denise G. Hemmings, Xiaoyun Tang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(9)
Compared to normal tissues, many cancer cells overexpress autotaxin (ATX). This secreted enzyme produces extracellular lysophosphatidate, which signals through 6 GPCRs to drive cancer progression. Our previous work showed that ATX inhibition decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290547d476bc2c2454efec11dcdd195c
https://pubmed.ncbi.nlm.nih.gov/26071407
https://pubmed.ncbi.nlm.nih.gov/26071407
Autor:
David N. Brindley, Irina Gorshkova, Carlos Pilquil, Anton Cherney, Jay Dewald, Gabor Tigyi, Denis English, Viswanathan Natarajan
Publikováno v:
Journal of Biological Chemistry. 281:38418-38429
Lysophosphatidate (LPA) stimulates cell migration and division through a family of G-protein-coupled receptors. Lipid phosphate phosphatase-1 (LPP1) regulates the degradation of extracellular LPA as well as the intracellular accumulation of lipid pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab9e7a229b31c6ecdb147d0d4343c55
https://doi.org/10.1074/jbc.m601670200
https://doi.org/10.1074/jbc.m601670200