Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jay DaRe"'
Autor:
Jay DaRe, Qun Dang, Mark D. Erion, Tony Gibson, Frank Taplin, Paul D. van Poelje, Yan Liu, Scott C. Potter, Srinivras Rao Kasibhatla, K. Raja Reddy, Wei Xiao, Gerard R. Scarlato
Publikováno v:
Journal of Medicinal Chemistry. 53:441-451
Efforts to enhance the inhibitory potency of the initial purine series of fructose-1,6-bisphosphatase (FBPase) inhibitors led to the discovery of a series of benzimidazole analogues with human FBPase IC(50)s < 100 nM. Inhibitor 4.4 emerged as a lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b77507b9a9519ff4310d803b2ebc1e
https://doi.org/10.1021/jm901420x
https://doi.org/10.1021/jm901420x
Autor:
and Juergen M. Schanzer, James B. Wiesner, Jay DaRe, Joseph J. Kopcho, Mark D. Erion, Angelo J. Castellino, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 43:2883-2893
Adenosine receptor agonists produce a wide variety of therapeutically useful pharmacologies. However, to date they have failed to undergo successful clinical development due to dose-limiting side effects. Adenosine kinase inhibitors (AKIs) represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3f55e87ad3ee4daefc2927c4c517af
https://doi.org/10.1021/jm000024g
https://doi.org/10.1021/jm000024g
Autor:
Ross Dixon, Mark D. Erion, James R. Appleman, Jay DaRe, James M. Fujitaki, Angelo J. Castellino, James B. Wiesner, Bheemarao G. Ugarkar
Publikováno v:
Nucleosides and Nucleotides. 16:1013-1021
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplished in 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df77e6c627d9d8665910c6793342031
https://doi.org/10.1080/07328319708006124
https://doi.org/10.1080/07328319708006124
Autor:
Jay DaRe, Tao Jiang, Scott C. Potter, Tony Gibson, Qun Dang, Frank Taplin, Yan Liu, Mark D. Erion, Daniel K. Cashion, Haiqing Li, Zhili Sun, Jason D. Jacintho, Paul D. van Poelje, Srinivas Rao Kasibhatla, Yi Fan, Lemus Robert Huerta, Feng Tian, Wenyu Li
Publikováno v:
Journal of medicinal chemistry. 54(1)
Oral delivery of previously disclosed purine and benzimidazole fructose-1,6-bisphosphatase (FBPase) inhibitors via prodrugs failed, which was likely due to their high molecular weight (>600). Therefore, a smaller scaffold was desired, and a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7227453a1b09fd9029c96cde2a01f99
https://pubmed.ncbi.nlm.nih.gov/21126019
https://pubmed.ncbi.nlm.nih.gov/21126019
Autor:
James M. Fujitaki, Angelo J. Castellino, Ross Dixon, Mark D. Erion, James R. Appleman, James B. Wiesner, Bheemarao G. Ugarkar, Jay DaRe
Publikováno v:
ChemInform. 29
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplished in 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14752f2339fe1090b1e00a40d690922
https://doi.org/10.1002/chin.199812195
https://doi.org/10.1002/chin.199812195
Autor:
Jay DaRe, Serge H. Boyer, Timothy J. Colby, Paul D. van Poelje, Mark D. Erion, Kristin Ollis, William Craigo, Zhili Sun, Michael C Matelich, Jorge E. Gomez-Galeno, James M. Fujitaki, K. Raja Reddy, Bheemarao G Ugarkar
Publikováno v:
Journal of medicinal chemistry. 51(3)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48405ee9f4b39744899156645820fd98
https://pubmed.ncbi.nlm.nih.gov/18173234
https://pubmed.ncbi.nlm.nih.gov/18173234
Publikováno v:
Nucleosides and Nucleotides. 9:649-662
Ribavirin and tiazofurin, two nucleosides of known antiviral activity, have been transformed by previously reported methods to yield several deoxy,epoxy, or dideoxy analogues. The deoxygenated derivatives were evaluated for antiviral activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce019e1bed05cf89810ae7c1a03211f
https://doi.org/10.1080/07328319008045196
https://doi.org/10.1080/07328319008045196
Publikováno v:
Neuroscience letters. 220(2)
The adenosine kinase inhibitor, 5'-deoxyiodotubercidin (5dITU), was examined in a rat focal stoke model with temporary (105 min) middle cerebral artery occlusion (MCAO) followed by a 24 h recovery period. Inhibition of this adenosine metabolizing enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102d947c121a3f520e6d7324895c4450
https://pubmed.ncbi.nlm.nih.gov/8981476
https://pubmed.ncbi.nlm.nih.gov/8981476
Autor:
Michael A. Ussery, Bjarne Gabrielsen, Melinda G. Hollingshead, John W. Huggins, Bheema Ugarkar, Michael J. Phelan, Jay DaRe, William M. Shannon, Ernst M. Schubert, Thomas P. Monath, Grazyna Groszek, Jorma J. Kirsi, George R. Pettit, Deborah F. Kefauver
Publikováno v:
Journal of natural products. 55(11)
A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were isolated or synthesized and subsequently evaluated in cell culture against the RNA-containing flaviviruses (Japanese encephalitis, yellow fever, and dengue viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a48da773af39ee5a8dd738abebce55f
https://pubmed.ncbi.nlm.nih.gov/1336040
https://pubmed.ncbi.nlm.nih.gov/1336040
Autor:
Qun Dang, Yan Liu, Daniel K. Cashion, Srinivas Rao Kasibhatla, Tao Jiang, Frank Taplin, Jason D. Jacintho, Haiqing Li, Zhili Sun, Yi Fan, Jay DaRe, Feng Tian, Wenyu Li, Tony Gibson, Robert Lemus, Paul D. van Poelje, Scott C. Potter, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jan2011, Vol. 54 Issue 1, p153-165, 13p