Výsledky vyhledávání - "Jay D. Tucker"

Evaluation of Tris[2-(Acryloyloxy)Ethyl]Isocyanurate Cross-Linked Polyethylenimine as Antisense Morpholino Oligomer Delivery Vehicle in Cell Culture and Dystrophic mdx Mice

Autor: Jay D. Tucker, Peijuan Lu, Qi Long Lu, Mingxing Wang, Bo Wu, Caryn Cloer

Publikováno v: Human Gene Therapy. 25:419-427

Hyperbranched poly(ester amine)s (PEAs) based on tris[2-(acryloyloxy)ethyl]isocyanurate (TAEI) cross-linked low-molecular-weight polyethylenimine (Mw: 0.8k/1.2k/2.0k) have been evaluated for delivering antisense phosphorodiamidate morpholino oligomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc40d27b4c668024dad0c22351ede7a3
https://doi.org/10.1089/hum.2013.156

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Synthesis and Evaluation of Tween 85-LPEI Copolymers for Gene Transfection In vitro and In vivo

Autor: Bo Wu, Mingxing Wang, Jay D. Tucker, Qilong Lu, Sapana N. Shah, Peijuan Lu, Shante Wade

Publikováno v: Journal of Nanomedicine & Nanotechnology.

A series of cationic amphiphlic copolymers constructed from Tween 85 and low molecular weight (Mw) polyethyleneimene (LPEI) were prepared in ambient conditions and characterized. The Mws of these copolymers ranged from around 5,000 to 25,000 Da and P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e03b6fe4e4341f02b8f89db3b130f97
https://doi.org/10.4172/2157-7439.1000228

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Polyethylenimine-modified pluronics (PCMs) improve morpholino oligomer delivery in cell culture and dystrophic mdx mice

Autor: Caryn Cloer, Qilong Lu, Mingxing Wang, Peijuan Lu, Jay D. Tucker, Bo Wu

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 21(1)

We investigated a series of small-sized polyethylenimine (PEI, 0.8/1.2 k)-conjugated pluronic copolymers (PCMs) for their potential to enhance delivery of an antisense phosphorodiamidate morpholino oligomer (PMO) in vitro and in dystrophic mdx mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512f18c32aac452949ac88cddcd835af
https://pubmed.ncbi.nlm.nih.gov/23164938

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Tris[2-(acryloyloxy)ethyl]isocyanurate cross-linked low-molecular-weight polyethylenimine as gene delivery carriers in cell culture and dystrophic mdx mice

Autor: Jay D. Tucker, Mingxing Wang, Peijuan Lu, Caryn Cloer, Bo Wu, Qilong Lu

Publikováno v: Bioconjugate chemistry. 23(4)

Hyperbranched poly(ester amine)s (PEAs) were successfully synthesized by Michael addition reaction between tris[2-(acryloyloxy)ethyl]isocyanurate (TAEI) and low-molecular-weight polyethylenimine (LPEI, M(w) 0.8k, 1.2k, and 2.0k) and evaluated in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bfb3c56d4c9f6806203a92fff734be
https://pubmed.ncbi.nlm.nih.gov/22443086

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High efficiency and low toxicity of polyethyleneimine modified Pluronics (PEI–Pluronic) as gene delivery carriers in cell culture and dystrophic mdx mice

Autor: Qilong Lu, Bo Wu, Caryn Cloer, Peijuan Lu, Jay D. Tucker, Mingxing Wang

Publikováno v: Journal of Materials Chemistry. 22:6038

A series of low molecular weight polyethyleneimine (LPEI) conjugated Pluronic copolymers (PCMs) were synthesized and evaluated in C2C12 myoblasts and CHO cells in vitro and in dystrophic mdx mice in vivo as gene delivery carriers. Pluronics with diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40cd8bc09476e590ca9e08057cba29e1
https://doi.org/10.1039/c2jm15625c

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