Zobrazeno 1 - 10
of 663
pro vyhledávání: '"Jay D. Keasling"'
Autor:
Vayu Maini Rekdal, Casper R. B. van der Luijt, Yan Chen, Ramu Kakumanu, Edward E. K. Baidoo, Christopher J. Petzold, Pablo Cruz-Morales, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Filamentous fungi are critical in the transition to a more sustainable food system. While genetic modification of these organisms has promise for enhancing the nutritional value, sensory appeal, and scalability of fungal foods, genetic tools
Externí odkaz:
https://doaj.org/article/8a9298b61ad143ee91c7a17fb92f654d
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Prediction of enzyme kinetic parameters is essential for designing and optimizing enzymes for various biotechnological and industrial applications, but the limited performance of current prediction tools on diverse tasks hinders their practi
Externí odkaz:
https://doaj.org/article/0a85aa29c73541739385a8859ac44ceb
Autor:
Huaxiang Deng, Han Yu, Yanwu Deng, Yulan Qiu, Feifei Li, Xinran Wang, Jiahui He, Weiyue Liang, Yunquan Lan, Longjiang Qiao, Zhiyu Zhang, Yunfeng Zhang, Jay D. Keasling, Xiaozhou Luo
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract The evolution of pathway enzymes enhances the biosynthesis of high‐value chemicals, crucial for pharmaceutical, and agrochemical applications. However, unpredictable evolutionary landscapes of pathway genes often hinder successful evolutio
Externí odkaz:
https://doaj.org/article/f3fe2bdd4eed45598f464ac030087d70
Autor:
Xiaoyue Chen, Graham A. Hudson, Charlotte Mineo, Bashar Amer, Edward E. K. Baidoo, Samantha A. Crowe, Yuzhong Liu, Jay D. Keasling, Henrik V. Scheller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese medicine, containing large quantities of oleanane-type triterpenoi
Externí odkaz:
https://doaj.org/article/23753f5fb290452c9ffd93a7880a98f0
Autor:
Elias Englund, Matthias Schmidt, Alberto A. Nava, Sarah Klass, Leah Keiser, Qingyun Dan, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new functional domains into PKSs to produc
Externí odkaz:
https://doaj.org/article/cac6e64bfec142468a38c3090a80d780
Autor:
Megan E. Garber, Vered Frank, Alexey E. Kazakov, Matthew R. Incha, Alberto A. Nava, Hanqiao Zhang, Luis E. Valencia, Jay D. Keasling, Lara Rajeev, Aindrila Mukhopadhyay
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThis report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance. Specificity between residues in REC domain containing response regulators with paired
Externí odkaz:
https://doaj.org/article/1b5e31e2aab640b78a76252a4e5a2252
Autor:
Thomas Eng, Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer Gin, Hemant Choudhary, Edward Baidoo, Jian Hua Chen, Axel Ekman, Ramu Kakumanu, Yuzhong Liu Diercks, Alex Codik, Carolyn Larabell, John Gladden, Blake A. Simmons, Jay D. Keasling, Christopher J. Petzold, Aindrila Mukhopadhyay
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113087- (2023)
Summary: Maximizing the production of heterologous biomolecules is a complex problem that can be addressed with a systems-level understanding of cellular metabolism and regulation. Specifically, growth-coupling approaches can increase product titers
Externí odkaz:
https://doaj.org/article/44231f8beb664554bcb8285ca80eab71
Autor:
Luis E. Valencia, Matthew R. Incha, Matthias Schmidt, Allison N. Pearson, Mitchell G. Thompson, Jacob B. Roberts, Marina Mehling, Kevin Yin, Ning Sun, Asun Oka, Patrick M. Shih, Lars M. Blank, John Gladden, Jay D. Keasling
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Pseudomonas putida has been engineered to produce medium chain length oleochemicals, including medium chain length free fatty acids and their ester forms, compounds which may be useful as biodiesel blending agents.
Externí odkaz:
https://doaj.org/article/3f49756fdf144786a1e7fe4a61fae5c4
Autor:
Peter B. Otoupal, Gina M. Geiselman, Asun M. Oka, Carolina A. Barcelos, Hemant Choudhary, Duy Dinh, Wenqing Zhong, HeeJin Hwang, Jay D. Keasling, Aindrila Mukhopadhyay, Eric Sundstrom, Robert W. Haushalter, Ning Sun, Blake A. Simmons, John M. Gladden
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-17 (2022)
Abstract Background Rhodosporidium toruloides is capable of co-utilization of complex carbon sources and robust growth from lignocellulosic hydrolysates. This oleaginous yeast is therefore an attractive host for heterologous production of valuable bi
Externí odkaz:
https://doaj.org/article/9d3a8f9fda414c0ba1547d0679e5e91e
Autor:
Lucas Waldburger, Mitchell G. Thompson, Alexandra J. Weisberg, Namil Lee, Jeff H. Chang, Jay D. Keasling, Patrick M. Shih
Publikováno v:
mSystems, Vol 8, Iss 4 (2023)
ABSTRACT Agrobacteria are a diverse, polyphyletic group of prokaryotes with multipartite genomes capable of transferring DNA into the genomes of host plants, making them an essential tool in plant biotechnology. Despite their utility in plant transfo
Externí odkaz:
https://doaj.org/article/9d88026871ca43c5854a4552a1ea73b5