Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Jay D. Horton"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109517- (2024)
Summary: Both humans and mice with congenital generalized lipodystrophy due to AGPAT2 deficiency develop diabetes mellitus, insulin resistance, and hepatic steatosis, which have been attributed to the near total loss of adipose tissue (AT). Here, we
Externí odkaz:
https://doaj.org/article/3b46cd7f3a354f9a9e35118f7af216af
Autor:
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Jay D. Horton, Abhimanyu Garg
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108653- (2024)
Summary: AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its me
Externí odkaz:
https://doaj.org/article/380c5aacd5c3490d8b8b1f8961965494
Autor:
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Philipp E. Scherer, Jay D. Horton, Abhimanyu Garg
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107806- (2023)
Summary: Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia
Externí odkaz:
https://doaj.org/article/cbfdbaa2bfeb492e96fa08ae536cb1d7
Autor:
Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice followi
Externí odkaz:
https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
Autor:
Min Kim, Changhu Lee, Dae Yun Seo, Hyojung Lee, Jay D. Horton, Jiyoung Park, Philipp E. Scherer
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1766-1776 (2020)
Liver disease: Collagen fragment spurs liver inflammation and fibrosis Localized buildup in the liver of a collagen-derived cleavage fragment plays a critical role in accelerating the development of tissue scarring and liver cancer in mice. Using a t
Externí odkaz:
https://doaj.org/article/e8c15da804804675993b7404515a3f3a
Autor:
Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, Mingjian Lu, Carlos M. Castorena, Shangang Zhao, Joel K. Elmquist, Philipp E. Scherer, Jay D. Horton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/1fc7f4c2eea94465b405660a8d64e00f
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100015- (2021)
Externí odkaz:
https://doaj.org/article/4a6b97e0a43f47f5898dc4461573f0bd
Autor:
Lin Jia, Xiuli Chang, Shuwen Qian, Chen Liu, Caleb C. Lord, Newaz Ahmed, Charlotte E. Lee, Syann Lee, Laurent Gautron, Mack C. Mitchell, Jay D. Horton, Philipp E. Scherer, Joel K. Elmquist
Publikováno v:
Molecular Metabolism, Vol 14, Iss , Pp 121-129 (2018)
Objective: Recent studies have suggested a critical role for toll-like receptor 4 (TLR4) in the development of alcoholic liver disease. As TLR4 is widely expressed throughout the body, it is unclear which TLR4-expressing cell types contribute to alco
Externí odkaz:
https://doaj.org/article/64821fd3953a4a47ac0d8555a040e0be
Autor:
Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 1-17 (2018)
Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. Methods: Here we have exami
Externí odkaz:
https://doaj.org/article/b2b47e6a4e904925aa53b722a829c482
Autor:
Albert G. Linden, Shili Li, Hwa Y. Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E. Hammer, Jay D. Horton, Luke J. Engelking, Guosheng Liang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 475-487 (2018)
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activat
Externí odkaz:
https://doaj.org/article/d01ebb180e1f41a7b9bb032aaf9d21a3