Zobrazeno 1 - 10
of 663
pro vyhledávání: '"Jay D, Keasling"'
Autor:
Vayu Maini Rekdal, Casper R. B. van der Luijt, Yan Chen, Ramu Kakumanu, Edward E. K. Baidoo, Christopher J. Petzold, Pablo Cruz-Morales, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Filamentous fungi are critical in the transition to a more sustainable food system. While genetic modification of these organisms has promise for enhancing the nutritional value, sensory appeal, and scalability of fungal foods, genetic tools
Externí odkaz:
https://doaj.org/article/8a9298b61ad143ee91c7a17fb92f654d
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Prediction of enzyme kinetic parameters is essential for designing and optimizing enzymes for various biotechnological and industrial applications, but the limited performance of current prediction tools on diverse tasks hinders their practi
Externí odkaz:
https://doaj.org/article/0a85aa29c73541739385a8859ac44ceb
Autor:
Huaxiang Deng, Han Yu, Yanwu Deng, Yulan Qiu, Feifei Li, Xinran Wang, Jiahui He, Weiyue Liang, Yunquan Lan, Longjiang Qiao, Zhiyu Zhang, Yunfeng Zhang, Jay D. Keasling, Xiaozhou Luo
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract The evolution of pathway enzymes enhances the biosynthesis of high‐value chemicals, crucial for pharmaceutical, and agrochemical applications. However, unpredictable evolutionary landscapes of pathway genes often hinder successful evolutio
Externí odkaz:
https://doaj.org/article/f3fe2bdd4eed45598f464ac030087d70
Autor:
Søren D Petersen, Lucas Levassor, Christine M Pedersen, Jan Madsen, Lea G Hansen, Jie Zhang, Ahmad K Haidar, Rasmus J N Frandsen, Jay D Keasling, Tilmann Weber, Nikolaus Sonnenschein, Michael K Jensen
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011929 (2024)
Synthetic biology dictates the data-driven engineering of biocatalysis, cellular functions, and organism behavior. Integral to synthetic biology is the aspiration to efficiently find, access, interoperate, and reuse high-quality data on genotype-phen
Externí odkaz:
https://doaj.org/article/c2a8272c0f8f4e8583e467f28cf7f764
Autor:
Xiaoyue Chen, Graham A. Hudson, Charlotte Mineo, Bashar Amer, Edward E. K. Baidoo, Samantha A. Crowe, Yuzhong Liu, Jay D. Keasling, Henrik V. Scheller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese medicine, containing large quantities of oleanane-type triterpenoi
Externí odkaz:
https://doaj.org/article/23753f5fb290452c9ffd93a7880a98f0
Autor:
Elias Englund, Matthias Schmidt, Alberto A. Nava, Sarah Klass, Leah Keiser, Qingyun Dan, Leonard Katz, Satoshi Yuzawa, Jay D. Keasling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new functional domains into PKSs to produc
Externí odkaz:
https://doaj.org/article/cac6e64bfec142468a38c3090a80d780
Autor:
Jacob B Roberts, Alberto A Nava, Allison N Pearson, Matthew R Incha, Luis E Valencia, Melody Ma, Abhay Rao, Jay D Keasling
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011171 (2024)
Foldy is a cloud-based application that allows non-computational biologists to easily utilize advanced AI-based structural biology tools, including AlphaFold and DiffDock. With many deployment options, it can be employed by individuals, labs, univers
Externí odkaz:
https://doaj.org/article/2575bc688d0540fea5c4ae20c9273503
Autor:
Megan E. Garber, Vered Frank, Alexey E. Kazakov, Matthew R. Incha, Alberto A. Nava, Hanqiao Zhang, Luis E. Valencia, Jay D. Keasling, Lara Rajeev, Aindrila Mukhopadhyay
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThis report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance. Specificity between residues in REC domain containing response regulators with paired
Externí odkaz:
https://doaj.org/article/1b5e31e2aab640b78a76252a4e5a2252
Autor:
Tyler W H Backman, Christina Schenk, Tijana Radivojevic, David Ando, Jahnavi Singh, Jeffrey J Czajka, Zak Costello, Jay D Keasling, Yinjie Tang, Elena Akhmatskaya, Hector Garcia Martin
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011111 (2023)
Metabolic fluxes, the number of metabolites traversing each biochemical reaction in a cell per unit time, are crucial for assessing and understanding cell function. 13C Metabolic Flux Analysis (13C MFA) is considered to be the gold standard for measu
Externí odkaz:
https://doaj.org/article/23460991878e4f2daf19048745ca008c
Autor:
Thomas Eng, Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer Gin, Hemant Choudhary, Edward Baidoo, Jian Hua Chen, Axel Ekman, Ramu Kakumanu, Yuzhong Liu Diercks, Alex Codik, Carolyn Larabell, John Gladden, Blake A. Simmons, Jay D. Keasling, Christopher J. Petzold, Aindrila Mukhopadhyay
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113087- (2023)
Summary: Maximizing the production of heterologous biomolecules is a complex problem that can be addressed with a systems-level understanding of cellular metabolism and regulation. Specifically, growth-coupling approaches can increase product titers
Externí odkaz:
https://doaj.org/article/44231f8beb664554bcb8285ca80eab71