Zobrazeno 1 - 10
of 518
pro vyhledávání: '"Jay D, Humphrey"'
Autor:
Mackenzie E. Turner, Kevin M. Blum, Tatsuya Watanabe, Erica L. Schwarz, Mahboubeh Nabavinia, Joseph T. Leland, Delaney J. Villarreal, William E. Schwartzman, Ting-Heng Chou, Peter B. Baker, Goki Matsumura, Rajesh Krishnamurthy, Andrew R. Yates, Kan N. Hor, Jay D. Humphrey, Alison L. Marsden, Mitchel R. Stacy, Toshiharu Shinoka, Christopher K. Breuer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures.
Externí odkaz:
https://doaj.org/article/f668f876930840c49404946d6ccd249c
Autor:
Edward P. Manning, Priti Mishall, Abhay B. Ramachandra, Abdulrahman H. M. Hassab, Jerome Lamy, Dana C. Peters, Terrence E. Murphy, Paul Heerdt, Inderjit Singh, Sherry Downie, Gaurav Choudhary, George Tellides, Jay D. Humphrey
Publikováno v:
Physiological Reports, Vol 12, Iss 12, Pp n/a-n/a (2024)
Abstract Adverse effects of large artery stiffening are well established in the systemic circulation; stiffening of the proximal pulmonary artery (PPA) and its sequelae are poorly understood. We combined in vivo (n = 6) with ex vivo data from cadaver
Externí odkaz:
https://doaj.org/article/1f7a7abc8e2f4d62a9080640619c7a21
Autor:
Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 1-13 (2024)
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistica
Externí odkaz:
https://doaj.org/article/99aa19c8944b4368939a87375caa3abd
Autor:
Sae-Il Murtada, Nicole Mikush, Mo Wang, Pengwei Ren, Yuki Kawamura, Abhay B Ramachandra, David S Li, Demetrios T Braddock, George Tellides, Leslie B Gordon, Jay D Humphrey
Publikováno v:
eLife, Vol 12 (2023)
Clinical trials have demonstrated that lonafarnib, a farnesyltransferase inhibitor, extends the lifespan in patients afflicted by Hutchinson-Gilford progeria syndrome, a devastating condition that accelerates many characteristics of aging and results
Externí odkaz:
https://doaj.org/article/f044f7f1664a46e8b1fa8ef58ff4d93a
Autor:
Allison M. Greaney, Abhay B. Ramachandra, Yifan Yuan, Arina Korneva, Jay D. Humphrey, Laura E. Niklason
Publikováno v:
Biomaterials and Biosystems, Vol 9, Iss , Pp 100074- (2023)
Tracheal replacement using tissue engineering technologies offers great potential to improve previously intractable clinical interventions, and interest in this area has increased in recent years. Many engineered airway constructs currently rely on d
Externí odkaz:
https://doaj.org/article/ff6ce22210604e1da76d7a727f8cbca0
Autor:
Kevin M. Blum, Jacob C. Zbinden, Abhay B. Ramachandra, Stephanie E. Lindsey, Jason M. Szafron, James W. Reinhardt, Megan Heitkemper, Cameron A. Best, Gabriel J. M. Mirhaidari, Yu-Chun Chang, Anudari Ulziibayar, John Kelly, Kejal V. Shah, Joseph D. Drews, Jason Zakko, Shinka Miyamoto, Yuichi Matsuzaki, Ryuma Iwaki, Hira Ahmad, Robbie Daulton, Drew Musgrave, Matthew G. Wiet, Eric Heuer, Emily Lawson, Erica Schwarz, Michael R. McDermott, Rajesh Krishnamurthy, Ramkumar Krishnamurthy, Kan Hor, Aimee K. Armstrong, Brian A. Boe, Darren P. Berman, Aaron J. Trask, Jay D. Humphrey, Alison L. Marsden, Toshiharu Shinoka, Christopher K. Breuer
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-21 (2022)
Plain language summary Surgery to correct defects in the heart that are present at birth sometimes requires the use of artificial blood vessels called vascular grafts. Tissue-engineered vascular grafts (TEVGs) are scaffolds seeded with cells that can
Externí odkaz:
https://doaj.org/article/cf83b6fbad07439fa512a6b4905d7efd
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010660 (2022)
Many genetic mutations adversely affect the structure and function of load-bearing soft tissues, with clinical sequelae often responsible for disability or death. Parallel advances in genetics and histomechanical characterization provide significant
Externí odkaz:
https://doaj.org/article/c301df38089f402db9f72b3d8f12c7ff
Autor:
Erica L. Schwarz, John M. Kelly, Kevin M. Blum, Kan N. Hor, Andrew R. Yates, Jacob C. Zbinden, Aekaansh Verma, Stephanie E. Lindsey, Abhay B. Ramachandra, Jason M. Szafron, Jay D. Humphrey, Toshiharu Shin’oka, Alison L. Marsden, Christopher K. Breuer
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
Abstract In the field of congenital heart surgery, tissue-engineered vascular grafts (TEVGs) are a promising alternative to traditionally used synthetic grafts. Our group has pioneered the use of TEVGs as a conduit between the inferior vena cava and
Externí odkaz:
https://doaj.org/article/f6b80589f56f438bab2b69bc93a66f5a
Autor:
Sameh Yousef, Nana Matsumoto, Issam Dabe, Makoto Mori, Alden B. Landry, Shin-Rong Lee, Yuki Kawamura, Chen Yang, Guangxin Li, Roland Assi, Prashanth Vallabhajosyula, Arnar Geirsson, Gilbert Moeckel, Jay D. Humphrey, George Tellides
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specime
Externí odkaz:
https://doaj.org/article/5b389f7fa447400a85fff10e77f7f93f
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract We implement a nonlinear rotation-free shell formulation capable of handling large deformations for applications in vascular biomechanics. The formulation employs a previously reported shell element that calculates both the membrane and bend
Externí odkaz:
https://doaj.org/article/a52ad75408fc471d9a1718ce4e4b5d7d