Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jay C. Jha"'
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1098 (2024)
Diabetic kidney disease (DKD) is a major microvascular complication of both type 1 and type 2 diabetes. DKD is characterised by injury to both glomerular and tubular compartments, leading to kidney dysfunction over time. It is one of the most common
Externí odkaz:
https://doaj.org/article/0390d89c6cc04d5394192f1915df10dc
Autor:
Karin A. M. Jandeleit-Dahm, Haritha R. Kankanamalage, Aozhi Dai, Jaroslawna Meister, Sara Lopez-Trevino, Mark E. Cooper, Rhian M. Touyz, Christopher R. J. Kennedy, Jay C. Jha
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 396 (2024)
Chronic hyperglycemia induces intrarenal oxidative stress due to the excessive production of reactive oxygen species (ROS), leading to a cascade of events that contribute to the development and progression of diabetic kidney disease (DKD). NOX5, a pr
Externí odkaz:
https://doaj.org/article/25b6f63d725f4dbfba27a16e2f8acc98
Autor:
Elham Hasheminasabgorji, Jay C. Jha
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1602 (2021)
The prevalence of diabetes is growing at an alarming rate with increased disability, morbidity, and often premature mortality because of the various complications of this disorder. Chronic hyperglycemia, dyslipidemia, and other metabolic alterations
Externí odkaz:
https://doaj.org/article/d5bf0b39bcbc43c7979cd8078e26cf61
Publikováno v:
Biology, Vol 10, Iss 1, p 18 (2020)
Oxidative stress and inflammation are considered major drivers in the pathogenesis of diabetic complications, including renal and cardiovascular disease. A symbiotic relationship also appears to exist between oxidative stress and inflammation. Severa
Externí odkaz:
https://doaj.org/article/82972c8036754db68f80a6e909fb1b2d
Autor:
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Publikováno v:
Østergaard, J A, Jha, J C, Sharma, A, Dai, A, Choi, J S Y, De Haan, J B, Cooper, M E & Jandeleit-Dah, K 2022, ' Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease ', Clinical Science, vol. 136, no. 2, pp. 167-180 . https://doi.org/10.1042/CS20210865
Clinical Science (London, England : 1979)
Clinical Science (London, England : 1979)
Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been reported in diabetic complications including diabetic kidney disease (DKD). However, it remains unknown if NLRP3 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb74c1c6696820a6519eb2f38a2726e
https://doi.org/10.1042/cs20210865
https://doi.org/10.1042/cs20210865
Autor:
TOMASZ J. BLOCK, KARLY SOURRIS, WAHEED KHAN, PHILLIP KANTHARIDIS, JAY C. JHA, MARK E. COOPER, JAMES SHAW, KARIN JANDELEIT-DAHM
Publikováno v:
Diabetes. 71
Background: Human NADPH oxidase 5 (NOX5) is expressed and functionally active in peripheral blood mononuclear cells (PBMCs) . In those with diabetes, there is increased NOX5 expression in atherosclerotic plaques with associated coronary artery diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb0e18d069c2797c54c9640cc57cdb72
https://doi.org/10.2337/db22-437-p
https://doi.org/10.2337/db22-437-p
Autor:
Kristy L. Jackson, Kyungjoon Lim, Jay C. Jha, Gavin W. Lambert, Sandra L. Burke, Kate M. Denton, Yusuke Sata, Cindy Gueguen, Geoffrey A. Head, Nina Eikelis, Markus P. Schlaich, Anna M. D. Watson
Publikováno v:
Hypertension. 76:1470-1479
Overactivity of the sympathetic nervous system and high blood pressure are implicated in the development and progression of chronic kidney disease (CKD) and independently predict cardiovascular events in end-stage renal disease. To assess the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3f39c472fa7de23ce67f86d5866442
https://doi.org/10.1161/hypertensionaha.120.15769
https://doi.org/10.1161/hypertensionaha.120.15769
Autor:
Kyungjoon Lim, Nina Eikelis, Geoffrey A. Head, Gavin W. Lambert, Karin Jandeleit-Dahm, Anna M. D. Watson, Kristy L. Jackson, Murray D. Esler, Kate M. Denton, Markus P. Schlaich, Yusuke Sata, Cindy Gueguen, Sandra L. Burke, Jay C. Jha
Publikováno v:
Kidney International. 98:906-917
Chronic kidney disease (CKD) is associated with greater sympathetic nerve activity but it is unclear if this is a kidney-specific response or due to generalized stimulation of sympathetic nervous system activity. To determine this, we used a rabbit m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d76817ea441d9ad403ef519960136ae
https://doi.org/10.1016/j.kint.2020.03.039
https://doi.org/10.1016/j.kint.2020.03.039
Autor:
Karin Jandeleit-Dahm, Rhian M. Touyz, Jay C. Jha, Chris R. J. Kennedy, Devy Deliyanti, Jennifer L. Wilkinson-Berka, Mark E. Cooper, Saeed F. Alrashdi
Publikováno v:
Hypertension. 75:1091-1101
Hypertension is a risk factor for the vascular permeability and neovascularization that threatens vision in diabetic retinopathy. Excess reactive oxygen species derived from the Nox (NADPH oxidase) isoforms, Nox1 and Nox4, contributes to vasculopathy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffa6cb2638a4baa3676cc329ad211cf
https://doi.org/10.1161/hypertensionaha.119.14100
https://doi.org/10.1161/hypertensionaha.119.14100
Autor:
Rhian M. Touyz, Chris R. J. Kennedy, Aozhi Dai, Chet E. Holterman, Mark E. Cooper, Karin Jandeleit-Dahm, Jay C. Jha
Publikováno v:
Diabetologia. 62:1712-1726
Excessive production of reactive oxygen species (ROS) plays a detrimental role in the progression of diabetic kidney disease (DKD). Renal oxidative stress activates proinflammatory cytokines, chemokines and profibrotic factors in DKD. Increased expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2961a235e728012f884946bb9499be63
https://doi.org/10.1007/s00125-019-4924-z
https://doi.org/10.1007/s00125-019-4924-z