Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Jay C. D Hinton"'
Autor:
Sam C. Went, David M. Picton, Richard D. Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T. F. Dryden, Darren L. Smith, Nicolas Wenner, Jay C. D. Hinton, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent
Externí odkaz:
https://doaj.org/article/f9d96556945641aca3006a94eb0b5cec
Autor:
Xiu-Jun Yu, Haixia Xie, Yan Li, Mei Liu, Ruhong Hou, Alexander V. Predeus, Blanca M. Perez Sepulveda, Jay C. D. Hinton, David W. Holden, Teresa L. M. Thurston
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The injectisome encoded by Salmonella pathogenicity island 2 (SPI-2) had been thought to translocate 28 effectors. Here, we used a proteomic approach to characterize the secretome of a clinical strain of invasive non-typhoidal Salmonella ent
Externí odkaz:
https://doaj.org/article/9ff9398d46de4a18a5884c97770df61d
Autor:
Sacha Lucchini, Gary Rowley, Martin D Goldberg, Douglas Hurd, Marcus Harrison, Jay C. D Hinton
Publikováno v:
PLoS Pathogens, Vol 3, Iss 3 (2007)
Externí odkaz:
https://doaj.org/article/4fc44f07c2754c3082cb2cabc162cf2f
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011142 (2024)
Succinate is a potent immune signalling molecule that is present in the mammalian gut and within macrophages. Both of these infection niches are colonised by the pathogenic bacterium Salmonella enterica serovar Typhimurium during infection. Succinate
Externí odkaz:
https://doaj.org/article/7d3489286e6f4e229084eb204fe19ab0
Autor:
Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting, Salmonella enterica serovar Typhimurium accounts for two-thirds of infections
Externí odkaz:
https://doaj.org/article/1918efc4b7e8470281477786c25f07d8
Autor:
Mengru Yang, Nicolas Wenner, Gregory F. Dykes, Yan Li, Xiaojun Zhu, Yaqi Sun, Fang Huang, Jay C. D. Hinton, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Bacteria have evolved proteinaceous microcompartments (BMCs) to control the passage of metabolites and facilitate catabolism in a micro-environment. Here, Yang et al. apply fluorescence microscopy to characterize the protein-protein interaction and a
Externí odkaz:
https://doaj.org/article/6d193cbb22f14b70807d6e6b500ec4a7
Autor:
Blanca M. Perez-Sepulveda, Darren Heavens, Caisey V. Pulford, Alexander V. Predeus, Ross Low, Hermione Webster, Gregory F. Dykes, Christian Schudoma, Will Rowe, James Lipscombe, Chris Watkins, Benjamin Kumwenda, Neil Shearer, Karl Costigan, Kate S. Baker, Nicholas A. Feasey, Jay C. D. Hinton, Neil Hall, The 10KSG consortium
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract We have developed an efficient and inexpensive pipeline for streamlining large-scale collection and genome sequencing of bacterial isolates. Evaluation of this method involved a worldwide research collaboration focused on the model organism
Externí odkaz:
https://doaj.org/article/80aa466e1a3f4e9db011fe11270b93a1
Autor:
Leonard Koolman, Reenesh Prakash, Yohane Diness, Chisomo Msefula, Tonney S Nyirenda, Franziska Olgemoeller, Paul Wigley, Blanca Perez-Sepulveda, Jay C D Hinton, Siân V Owen, Nicholas A Feasey, Philip M Ashton, Melita A Gordon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 12, p e0010982 (2022)
BackgroundInvasive Salmonella infections cause significant morbidity and mortality in Sub-Saharan Africa. However, the routes of transmission are uncertain. We conducted a case-control study of index-case and geographically-matched control households
Externí odkaz:
https://doaj.org/article/0c00ab7221454b23a3314b59b9255fc9
Autor:
Sarah Gallichan, Blanca M. Perez-Sepulveda, Nicholas A. Feasey, Jay C. D. Hinton, Juno Thomas, Anthony Marius Smith
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Salmonella enterica serovar Enteritidis is one of the most commonly reported serovars of nontyphoidal Salmonella causing human disease and is responsible for both gastroenteritis and invasive nontyphoidal Salmonella (iNTS) disease worldwide.
Externí odkaz:
https://doaj.org/article/a2bfe887ed5143e5a24964f3f11e94ae
Autor:
Mengru Yang, Deborah M. Simpson, Nicolas Wenner, Philip Brownridge, Victoria M. Harman, Jay C. D. Hinton, Robert J. Beynon, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Enteric pathogens such as Salmonella depend on propanediol-utilising microcompartments (Pdu MCP), which self-assemble from cytosolic proteins. Using mass spectrometry-based absolute quantification, the authors here define the protein stoichiometry an
Externí odkaz:
https://doaj.org/article/b8d56250827a4705bb5c667f33be65dc