Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jay B, Fell"'
Autor:
James G. Christensen, Peter Olson, Pasi A. Jänne, Kyriakos P. Papadopoulos, Piro Lito, Sai-Hong Ignatius Ou, Melissa L. Johnson, Igor I. Rybkin, Matthew A. Marx, Douglas P. Cassidy, Emanuel F. Patricoin, Elisa Baldelli, Mariaelena Pierobon, Jeremy Barton, Richard C. Chao, Karen Velastagui, Adam Pavlicek, Julio Fernandez-Banet, Sole Gatto, Yaohua Xue, Guy P. Vigers, John P. Fischer, Jay B. Fell, Michael R. Burkard, Joshua A. Ballard, Brian R. Baer, Vickie Bowcut, Niranjan Sudhakar, David M. Briere, Ruth Aranda, Andrew Calinisan, Lauren Hargis, Lars D. Engstrom, Jill Hallin
Supplementary Composite Figure File
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095624453d8ad8530fb345958c4cd8b6
https://doi.org/10.1158/2159-8290.22535530.v1
https://doi.org/10.1158/2159-8290.22535530.v1
Autor:
James G. Christensen, Peter Olson, Pasi A. Jänne, Kyriakos P. Papadopoulos, Piro Lito, Sai-Hong Ignatius Ou, Melissa L. Johnson, Igor I. Rybkin, Matthew A. Marx, Douglas P. Cassidy, Emanuel F. Patricoin, Elisa Baldelli, Mariaelena Pierobon, Jeremy Barton, Richard C. Chao, Karen Velastagui, Adam Pavlicek, Julio Fernandez-Banet, Sole Gatto, Yaohua Xue, Guy P. Vigers, John P. Fischer, Jay B. Fell, Michael R. Burkard, Joshua A. Ballard, Brian R. Baer, Vickie Bowcut, Niranjan Sudhakar, David M. Briere, Ruth Aranda, Andrew Calinisan, Lauren Hargis, Lars D. Engstrom, Jill Hallin
Despite decades of research, efforts to directly target KRAS have been challenging. MRTX849 was identified as a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd866fa6fe03bc0849986ce88d5870c4
https://doi.org/10.1158/2159-8290.c.6547879.v1
https://doi.org/10.1158/2159-8290.c.6547879.v1
Autor:
Xiaolun Wang, Shelley Allen, James F. Blake, Vickie Bowcut, David M. Briere, Andrew Calinisan, Joshua R. Dahlke, Jay B. Fell, John P. Fischer, Robin J. Gunn, Jill Hallin, Jade Laguer, J. David Lawson, James Medwid, Brad Newhouse, Phong Nguyen, Jacob M. O’Leary, Peter Olson, Spencer Pajk, Lisa Rahbaek, Mareli Rodriguez, Christopher R. Smith, Tony P. Tang, Nicole C. Thomas, Darin Vanderpool, Guy P. Vigers, James G. Christensen, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:3123-3133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a806650aaec5c7d35ae8ff6555c3535
https://doi.org/10.1021/acs.jmedchem.1c01688
https://doi.org/10.1021/acs.jmedchem.1c01688
Autor:
Xiaolun, Wang, Shelley, Allen, James F, Blake, Vickie, Bowcut, David M, Briere, Andrew, Calinisan, Joshua R, Dahlke, Jay B, Fell, John P, Fischer, Robin J, Gunn, Jill, Hallin, Jade, Laguer, J David, Lawson, James, Medwid, Brad, Newhouse, Phong, Nguyen, Jacob M, O'Leary, Peter, Olson, Spencer, Pajk, Lisa, Rahbaek, Mareli, Rodriguez, Christopher R, Smith, Tony P, Tang, Nicole C, Thomas, Darin, Vanderpool, Guy P, Vigers, James G, Christensen, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 65(4)
KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28a8a679ffc406047b45ef523fe5e8f2
https://pubmed.ncbi.nlm.nih.gov/36284185
https://pubmed.ncbi.nlm.nih.gov/36284185
Autor:
Jay B, Fell, John P, Fischer, Brian R, Baer, James F, Blake, Karyn, Bouhana, David M, Briere, Karin D, Brown, Laurence E, Burgess, Aaron C, Burns, Michael R, Burkard, Harrah, Chiang, Mark J, Chicarelli, Adam W, Cook, John J, Gaudino, Jill, Hallin, Lauren, Hanson, Dylan P, Hartley, Erik J, Hicken, Gary P, Hingorani, Ronald J, Hinklin, Macedonio J, Mejia, Peter, Olson, Jennifer N, Otten, Susan P, Rhodes, Martha E, Rodriguez, Pavel, Savechenkov, Darin J, Smith, Niranjan, Sudhakar, Francis X, Sullivan, Tony P, Tang, Guy P, Vigers, Lance, Wollenberg, James G, Christensen, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 63(13)
Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new technologies and strategies are aiding in the target's resurgence. As previously reported, the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc99717000ce420f505732f20b4224e4
https://pubmed.ncbi.nlm.nih.gov/32250617
https://pubmed.ncbi.nlm.nih.gov/32250617
Autor:
Jill, Hallin, Lars D, Engstrom, Lauren, Hargis, Andrew, Calinisan, Ruth, Aranda, David M, Briere, Niranjan, Sudhakar, Vickie, Bowcut, Brian R, Baer, Joshua A, Ballard, Michael R, Burkard, Jay B, Fell, John P, Fischer, Guy P, Vigers, Yaohua, Xue, Sole, Gatto, Julio, Fernandez-Banet, Adam, Pavlicek, Karen, Velastagui, Richard C, Chao, Jeremy, Barton, Mariaelena, Pierobon, Elisa, Baldelli, Emanuel F, Patricoin, Douglas P, Cassidy, Matthew A, Marx, Igor I, Rybkin, Melissa L, Johnson, Sai-Hong Ignatius, Ou, Piro, Lito, Kyriakos P, Papadopoulos, Pasi A, Jänne, Peter, Olson, James G, Christensen
Publikováno v:
Cancer discovery. 10(1)
Despite decades of research, efforts to directly target KRAS have been challenging. MRTX849 was identified as a potent, selective, and covalent KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ef3d07a71c1efe4ae1da70ed55065bb
https://pubmed.ncbi.nlm.nih.gov/31919120
https://pubmed.ncbi.nlm.nih.gov/31919120
Autor:
Gary M. Coppola, Jay B. Fell
Publikováno v:
Synthetic Communications. 25:43-47
Mono and diaryl carbodiimides were prepared in high yield under mild conditions by treating a thiourea with methanesulfonyl chloride in the presence of triethylamine and DMAP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a82bf21f7f9a80c03c245be28a81db
https://doi.org/10.1080/00397919508010787
https://doi.org/10.1080/00397919508010787
Autor:
Gary M. Coppola, Jay B. Fell
Publikováno v:
ChemInform. 26
Mono and diaryl carbodiimides were prepared in high yield under mild conditions by treating a thiourea with methanesulfonyl chloride in the presence of triethylamine and DMAP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42730ef055d65dbd41b39cc581283f71
https://doi.org/10.1002/chin.199524096
https://doi.org/10.1002/chin.199524096