Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jay A. Walters"'
Autor:
Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101632- (2022)
Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT
Externí odkaz:
https://doaj.org/article/1c21859e313c4bbbb1ba43957ea7e539
Autor:
Lynley D Pound, Suparna A Sarkar, Alessandro Ustione, Prasanna K Dadi, Melanie K Shadoan, Catherine E Lee, Jay A Walters, Masakazu Shiota, Owen P McGuinness, David A Jacobson, David W Piston, John C Hutton, David R Powell, Richard M O'Brien
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40972 (2012)
The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have exa
Externí odkaz:
https://doaj.org/article/b95eb3a5326d42179669db493b53d656
Autor:
Kimberly T. Fowler, Ong Moua, Janet M. Wenzlau, Liping Yu, Howard W. Davidson, John C. Hutton, Yu Liu, Jay A. Walters, George S. Eisenbarth, Sampathkumar Rangasamy
Publikováno v:
Diabetes
OBJECTIVE—Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabetes in genome-wide association studies. The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cbbb242e68bbb6f67b015a83cb65e7
http://europepmc.org/articles/PMC2551679
http://europepmc.org/articles/PMC2551679
Autor:
Shelley R. Allen, Brian P. Flemming, Cyrus C. Martin, James K. Oeser, Richard M. O'Brien, Yingda Wang, John C. Hutton, Jay A. Walters
Publikováno v:
Diabetes. 57:133-141
OBJECTIVE—Islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP) is selectively expressed in islet β-cells and is a major autoantigen in both mouse and human type 1 diabetes. This study describes the use of a combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818462f92dc7db6ed4e786d7a6c0bf36
https://doi.org/10.2337/db07-0092
https://doi.org/10.2337/db07-0092
Autor:
Jason D. Dinella, Suparna A. Sarkar, Hannah R. Tipney, Lawrence Hunter, Anis Karimpour-Fard, Catherine E. Lee, John C. Hutton, Kirstine Juhl, Jay A. Walters
The molecular mechanism of pancreatic morphogenesis and differentiation is a fundamental enigma during pancreas development. Early pancreatic organogenesis shares a common pool of pancreatic progenitor cells that originate from the foregut endoderm1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c4a54f255ddd508a6b4523601083a2
https://europepmc.org/articles/PMC3387325/
https://europepmc.org/articles/PMC3387325/
Autor:
Adam L. Burrack, Steven K. Hildemann, Tom T. Nguyen, Francisco Victorino, Jay A. Walters, Catherine E. Lee, Dirk Homann, Suparna A. Sarkar, Jens Eberlein
Publikováno v:
Diabetes
More than one-half of the ~50 human chemokines have been associated with or implicated in the pathogenesis of type 1 diabetes, yet their actual expression patterns in the islet environment of type 1 diabetic patients remain, at present, poorly define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5569012b0cf1fd088dba179acad8bca
https://pubmed.ncbi.nlm.nih.gov/22210319
https://pubmed.ncbi.nlm.nih.gov/22210319
Autor:
Masakazu Shiota, Owen P. McGuinness, Suparna A. Sarkar, Lynley D. Pound, Catherine E. Lee, David R. Powell, John C. Hutton, Prasanna K. Dadi, Jay A. Walters, Richard M. O'Brien, David W. Piston, David A. Jacobson, Alessandro Ustione, Melanie K. Shadoan
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40972 (2012)
PLoS ONE
PLoS ONE
Competing Interests: MKS and DRP work for Lexicon Pharmaceuticals and generated the mice described in this study. There are no pending patents, products in development or marketed products associated with these mice or this study. This relationship b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac806cb3835592536755d739205f957
http://europepmc.org/articles/PMC3400647?pdf=render
http://europepmc.org/articles/PMC3400647?pdf=render
Autor:
Jay A. Walters, Sun-Sang J. Sung
Publikováno v:
Journal of Clinical Investigation. 88:1915-1923
The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined. Peripheral monocytes and myelomonocytic cell lines could be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc371436c59ad9e9ec8d565d48ea53c
https://doi.org/10.1172/jci115515
https://doi.org/10.1172/jci115515
Publikováno v:
The Journal of biological chemistry. 274(15)
The ability to induce the oncogenic activation of the human prolactin receptor (PRLR) was examined by deleting 178 amino acids of the extracellular ligand-binding domain. Expression of this deletion mutant in the interleukin-3 (IL-3)-dependent murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d08632033d92e573d15262023b11f1
https://pubmed.ncbi.nlm.nih.gov/10187780
https://pubmed.ncbi.nlm.nih.gov/10187780