Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Jay A Nelson"'
Autor:
Kristen Zarrella, Pierce Longmire, Sebastian Zeltzer, Donna Collins-McMillen, Meaghan Hancock, Jason Buehler, Justin M Reitsma, Scott S Terhune, Jay A Nelson, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011185 (2023)
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defining the vi
Externí odkaz:
https://doaj.org/article/d85e8154b8e44746b556114c61bcbb75
Autor:
Jason Buehler, Ethan Carpenter, Sebastian Zeltzer, Suzu Igarashi, Michael Rak, Iliyana Mikell, Jay A Nelson, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008037 (2019)
Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirus (CMV), regulates epidermal growth factor receptor (EG
Externí odkaz:
https://doaj.org/article/6909a4bc7d2a4f4195df707e9152948a
Autor:
Iliyana Mikell, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jason Buehler, Felicia Goodrum, Jay A Nelson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1007854 (2019)
Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following mobili
Externí odkaz:
https://doaj.org/article/c5b0156f73024df2935fdfc37b1ec146
Autor:
Alec J Hirsch, Jessica L Smith, Nicole N Haese, Rebecca M Broeckel, Christopher J Parkins, Craig Kreklywich, Victor R DeFilippis, Michael Denton, Patricia P Smith, William B Messer, Lois M A Colgin, Rebecca M Ducore, Peta L Grigsby, Jon D Hennebold, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Clayton A Wiley, Jay A Nelson, Daniel N Streblow
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006317 (2017)
[This corrects the article DOI: 10.1371/journal.ppat.1006219.].
Externí odkaz:
https://doaj.org/article/116ea9460e3f48fe8753fbc0acc79393
Autor:
Alec J Hirsch, Jessica L Smith, Nicole N Haese, Rebecca M Broeckel, Christopher J Parkins, Craig Kreklywich, Victor R DeFilippis, Michael Denton, Patricia P Smith, William B Messer, Lois M A Colgin, Rebecca M Ducore, Peta L Grigsby, Jon D Hennebold, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Clayton A Wiley, Jay A Nelson, Daniel N Streblow
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006219 (2017)
Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcephaly and othe
Externí odkaz:
https://doaj.org/article/55de2daddda341f08d68238e192dcd1f
Autor:
Benjamin J Burwitz, Daniel Malouli, Benjamin N Bimber, Jason S Reed, Abigail B Ventura, Meaghan H Hancock, Luke S Uebelhoer, Amruta Bhusari, Katherine B Hammond, Renee G Espinosa Trethewy, Alex Klug, Alfred W Legasse, Michael K Axthelm, Jay A Nelson, Byung S Park, Daniel N Streblow, Scott G Hansen, Louis J Picker, Klaus Früh, Jonah B Sacha
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006014 (2016)
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of
Externí odkaz:
https://doaj.org/article/7f89ac2e54d24ee7a16db764f546ae92
Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.
Autor:
Igor Landais, Chantel Pelton, Daniel Streblow, Victor DeFilippis, Shannon McWeeney, Jay A Nelson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004881 (2015)
Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs. L
Externí odkaz:
https://doaj.org/article/18dec7fffc8246b48fa924372a338c03
Autor:
Mahadevaiah Umashankar, Alex Petrucelli, Louis Cicchini, Patrizia Caposio, Craig N Kreklywich, Michael Rak, Farah Bughio, Devorah C Goldman, Kimberly L Hamlin, Jay A Nelson, William H Fleming, Daniel N Streblow, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002444 (2011)
Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have previously identified ULb'-encoded pUL138 as necessary, but not suffi
Externí odkaz:
https://doaj.org/article/ad3d589c837c45a4a85163673d1fb1ed
Autor:
Kasinath Viswanathan, M Shane Smith, Daniel Malouli, Mandana Mansouri, Jay A Nelson, Klaus Früh
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002332 (2011)
Interferon-induced BST2/Tetherin prevents budding of vpu-deficient HIV-1 by tethering mature viral particles to the plasma membrane. BST2 also inhibits release of other enveloped viruses including Ebola virus and Kaposi's sarcoma associated herpesvir
Externí odkaz:
https://doaj.org/article/1ede8b7d00e648df9b409b2af55bef5a
Autor:
Finn Grey, Rebecca Tirabassi, Heather Meyers, Guanming Wu, Shannon McWeeney, Lauren Hook, Jay A Nelson
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000967 (2010)
Global gene expression data combined with bioinformatic analysis provides strong evidence that mammalian miRNAs mediate repression of gene expression primarily through binding sites within the 3' untranslated region (UTR). Using RNA induced silencing
Externí odkaz:
https://doaj.org/article/c1ba2ad74b4b4f7d9b8089c45232e559