Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Jay A, Nelson"'
Autor:
Kristen Zarrella, Pierce Longmire, Sebastian Zeltzer, Donna Collins-McMillen, Meaghan Hancock, Jason Buehler, Justin M Reitsma, Scott S Terhune, Jay A Nelson, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011185 (2023)
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defining the vi
Externí odkaz:
https://doaj.org/article/d85e8154b8e44746b556114c61bcbb75
Autor:
Alison L. Greggor, Bryce Masuda, Jacqueline M. Gaudioso-Levita, Jay T. Nelson, Thomas H. White, Debra M. Shier, Susan M. Farabaugh, Ronald R. Swaisgood
Publikováno v:
Global Ecology and Conservation, Vol 28, Iss , Pp e01658- (2021)
Animal translocations commonly fail due to predation after release, especially if animals are reared in human care, away from natural predation pressure. Anti-predator training can be a useful tool for combating the predator naivety of released anima
Externí odkaz:
https://doaj.org/article/c9286306daf14cad8589826ac3c2b5e5
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Each herpesvirus family establishes latency in a unique cell type. Since herpesviruses genomes are maintained as episomes, the viruses need to devise mechanisms to retain the latent genome during cell division.
Externí odkaz:
https://doaj.org/article/7beab12f4ad247e89b494036072c8109
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Regulation of epidermal growth factor (EGF) receptor (EGFR) signaling is critical for the replication of human cytomegalovirus (HCMV) as well as latency and reactivation in CD34+ hematopoietic progenitor cells. HCMV microRNAs (miRNAs) provid
Externí odkaz:
https://doaj.org/article/6fdb1ca1cc864a0d8b43f9ebdb42720b
Autor:
Alec J. Hirsch, Victoria H. J. Roberts, Peta L. Grigsby, Nicole Haese, Matthias C. Schabel, Xiaojie Wang, Jamie O. Lo, Zheng Liu, Christopher D. Kroenke, Jessica L. Smith, Meredith Kelleher, Rebecca Broeckel, Craig N. Kreklywich, Christopher J. Parkins, Michael Denton, Patricia Smith, Victor DeFilippis, William Messer, Jay A. Nelson, Jon D. Hennebold, Marjorie Grafe, Lois Colgin, Anne Lewis, Rebecca Ducore, Tonya Swanson, Alfred W. Legasse, Michael K. Axthelm, Rhonda MacAllister, Ashlee V. Moses, Terry K. Morgan, Antonio E. Frias, Daniel N. Streblow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection res
Externí odkaz:
https://doaj.org/article/b27991f416df40acb0fbda1482c193c4
Autor:
Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Craig Kreklywich, Patricia Smith, Louis J. Picker, Jay A. Nelson, Patrizia Caposio
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The strict species specificity of Human Cytomegalovirus (HCMV) has impeded our understanding of antiviral adaptive immune responses in the context of a human immune system. We have previously shown that HCMV infection of human hematopoietic
Externí odkaz:
https://doaj.org/article/63f137c8af204eeab7c5949faeb8e663
Autor:
Jason Buehler, Ethan Carpenter, Sebastian Zeltzer, Suzu Igarashi, Michael Rak, Iliyana Mikell, Jay A Nelson, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008037 (2019)
Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirus (CMV), regulates epidermal growth factor receptor (EG
Externí odkaz:
https://doaj.org/article/6909a4bc7d2a4f4195df707e9152948a
Autor:
Iliyana Mikell, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jason Buehler, Felicia Goodrum, Jay A Nelson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1007854 (2019)
Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following mobili
Externí odkaz:
https://doaj.org/article/c5b0156f73024df2935fdfc37b1ec146
Autor:
Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Human cytomegalovirus (HCMV) infection of CD34+ hematopoietic progenitor cells (CD34+ HPCs) provides a critical reservoir of virus in stem cell transplant patients, and viral reactivation remains a significant cause of morbidity and mortalit
Externí odkaz:
https://doaj.org/article/2213cd7c92b0456f946b96b2a577e848
Autor:
Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Andrew D. Yurochko, Felicia D. Goodrum, Jay A. Nelson, Patrizia Caposio
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 525 (2020)
Human cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment. Despite the clear clinical link between myelosuppr
Externí odkaz:
https://doaj.org/article/fd04cf77fd6d44d2a57c0f8ec7654d01