Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis.

Autor: Mulenga H; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Musvosvi M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Mendelsohn SC; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Penn-Nicholson A; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Kimbung Mbandi S; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Fiore-Gartland A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Tameris M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Mabwe S; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Africa H; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Bilek N; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Kafaar F; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Khader SA; Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri., Carstens B; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Hadley K; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Hikuam C; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Erasmus M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Jaxa L; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Raphela R; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Nombida O; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Kaskar M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Nicol MP; Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Division of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Perth, Australia., Mbhele S; Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Van Heerden J; Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Innes C; The Aurum Institute, Johannesburg, Guateng, South Africa., Brumskine W; The Aurum Institute, Johannesburg, Guateng, South Africa., Hiemstra A; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical TB Research and SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Malherbe ST; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical TB Research and SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Hassan-Moosa R; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Medical Research Council-CAPRISA HIV-Tuberculosis Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; and., Walzl G; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical TB Research and SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Naidoo K; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Medical Research Council-CAPRISA HIV-Tuberculosis Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; and., Churchyard G; The Aurum Institute, Johannesburg, Guateng, South Africa.; School of Public Health, University of Witwatersrand, Johannesburg, South Africa., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and., Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, and.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Dec 15; Vol. 204 (12), pp. 1463-1472.

Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.

Autor: Mendelsohn SC; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Fiore-Gartland A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Penn-Nicholson A; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Mulenga H; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Mbandi SK; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Borate B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hadley K; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Hikuam C; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Musvosvi M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Bilek N; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Erasmus M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Jaxa L; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Raphela R; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Nombida O; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Kaskar M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Sumner T; TB Modelling Group, TB Centre, Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., White RG; TB Modelling Group, TB Centre, Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Innes C; The Aurum Institute, Johannesburg, South Africa., Brumskine W; The Aurum Institute, Johannesburg, South Africa., Hiemstra A; DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa; SAMRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa., Malherbe ST; DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa; SAMRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa., Hassan-Moosa R; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa; MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Tameris M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Walzl G; DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa; SAMRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa., Naidoo K; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa; MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Churchyard G; The Aurum Institute, Johannesburg, South Africa; School of Public Health, University of Witwatersrand, Johannesburg, South Africa., Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address: mark.hatherill@uct.ac.za.

Publikováno v: The Lancet. Global health [Lancet Glob Health] 2021 Jun; Vol. 9 (6), pp. e841-e853. Date of Electronic Publication: 2021 Apr 13.

T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation.

Autor: Musvosvi M; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Duffy D; Laboratory of Dendritic Cell Immunobiology, Dept of Immunology, Institut Pasteur, Paris, France.; INSERM U1223, Paris, France., Filander E; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Africa H; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Mabwe S; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Jaxa L; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Bilek N; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Llibre A; Laboratory of Dendritic Cell Immunobiology, Dept of Immunology, Institut Pasteur, Paris, France.; INSERM U1223, Paris, France., Rouilly V; Laboratory of Dendritic Cell Immunobiology, Dept of Immunology, Institut Pasteur, Paris, France.; INSERM U1223, Paris, France., Hatherill M; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa., Albert M; Laboratory of Dendritic Cell Immunobiology, Dept of Immunology, Institut Pasteur, Paris, France.; INSERM U1223, Paris, France.; Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA., Scriba TJ; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa.; These authors contributed equally., Nemes E; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa.; These authors contributed equally.

Publikováno v: The European respiratory journal [Eur Respir J] 2018 Mar 22; Vol. 51 (3). Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018).

An Exploratory Study of Early Immune Response Markers for Pembrolizumab in Urothelial Tract Cancer.

Autor: Stormoen, Dag Rune^1,2,3,4 (AUTHOR) dag.rune.stormoen@regionh.dk, Omland, Lise Høj¹ (AUTHOR), Mouw, Kent William^2,3,5 (AUTHOR), Szallasi, Zoltan^6,7,8,9 (AUTHOR), Ostrowski, Sisse Rye^4,10 (AUTHOR), Nielsen, Susanne Dam^4,11 (AUTHOR), Pappot, Helle^1,4 (AUTHOR)

Publikováno v: Uro. Mar2024, Vol. 4 Issue 1, p1-11. 11p.

Commercially available CD4 + and CD8 + IFN-γ release assays combined with an HBHA-induced IGRA improve the characterization of the tuberculosis spectrum and monitoring of treatment in children.

Autor: Buonsenso, Danilo^1,2 (AUTHOR) danilo.buonsenso@policlinicogemelli.it, Delogu, Giovanni^3,4 (AUTHOR), del Carmen Pereyra Boza, Maria³ (AUTHOR), De Maio, Flavio³ (AUTHOR), Palucci, Ivana^3,4 (AUTHOR), Martino, Laura¹ (AUTHOR), Pata, Davide¹ (AUTHOR), Sanguinetti, Maurizio^3,4 (AUTHOR), Valentini, Piero^1,2 (AUTHOR), Sali, Michela^3,4 (AUTHOR)

Publikováno v: European Journal of Pediatrics. May2023, Vol. 182 Issue 5, p2155-2167. 13p. 1 Diagram, 1 Chart, 5 Graphs.