Dual modulation of urinary bladder activity and urine flow by prostanoid EP3 receptors in the conscious rat.

Autor: Jugus, MJ¹, Jaworski, JP², Patra, PB¹, Jin, J³, Morrow, DM², Laping, NJ¹, Edwards, RM¹, Thorneloe, KS¹, Jugus, M J⁴ (AUTHOR), Jaworski, J P (AUTHOR), Patra, P B (AUTHOR), Morrow, D M (AUTHOR), Laping, N J (AUTHOR), Edwards, R M (AUTHOR), Thorneloe, K S (AUTHOR)

Publikováno v: British Journal of Pharmacology. Sep2009, Vol. 158 Issue 1, p372-381. 10p.

Inter-laboratory comparison of eleven quantitative or digital PCR assays for detection of proviral bovine leukemia virus in blood samples.

Autor: Pluta A; Department of Biochemistry, National Veterinary Research Institute, Puławy, 24-100, Poland. aneta.pluta@piwet.pulawy.pl.; Department of Omics Analyses, National Veterinary Research Institute, 24-100, Puławy, Poland. aneta.pluta@piwet.pulawy.pl., Jaworski JP; Instituto de Virología E Innovaciones Tecnológicas (IVIT), Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA) - CONICET, Buenos Aires, Argentina., Droscha C; CentralStar Cooperative, 4200 Forest Rd, Lansing, MI, 48910, USA., VanderWeele S; CentralStar Cooperative, 4200 Forest Rd, Lansing, MI, 48910, USA., Taxis TM; Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, Michigan, 48824, USA., Valas S; Niort Laboratory, Unit Pathology and Welfare of Ruminants, French Agency for Food, Environmental and Occupational Health and Safety (Anses), Ploufragan-Plouzané, Niort, France., Brnić D; Croatian Veterinary Institute, Savska Cesta 143, Zagreb, 10000, Croatia., Jungić A; Croatian Veterinary Institute, Savska Cesta 143, Zagreb, 10000, Croatia., Ruano MJ; Laboratorio Central de Veterinaria (LCV), Ministry of Agriculture, Fisheries and Food, Carretera M-106 (Km 1,4), Madrid, Algete, 28110, Spain., Sánchez A; Laboratorio Central de Veterinaria (LCV), Ministry of Agriculture, Fisheries and Food, Carretera M-106 (Km 1,4), Madrid, Algete, 28110, Spain., Murakami K; Department of Veterinary Sciences, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, 020-8550, Japan., Nakamura K; Department of Veterinary Sciences, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, 020-8550, Japan., Puentes R; Departamento de Patobiología, Facultad de Veterinaria, Unidad de Microbiología, Universidad de La República, Ruta 8, Km 18, Montevideo, 13000, Uruguay., De Brun M; Departamento de Patobiología, Facultad de Veterinaria, Unidad de Microbiología, Universidad de La República, Ruta 8, Km 18, Montevideo, 13000, Uruguay., Ruiz V; Instituto de Virología E Innovaciones Tecnológicas (IVIT), Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), Instituto Nacional de Tecnología Agropecuaria (INTA) - CONICET, Buenos Aires, Argentina., Gómez MEL; Laboratorio de Virología, Departamento SAMP, Centro de Investigación Veterinaria de Tandil-CIVETAN (CONICET/UNCPBA/CICPBA), Buenos Aires, Argentina., Lendez P; Laboratorio de Virología, Departamento SAMP, Centro de Investigación Veterinaria de Tandil-CIVETAN (CONICET/UNCPBA/CICPBA), Buenos Aires, Argentina., Dolcini G; Laboratorio de Virología, Departamento SAMP, Centro de Investigación Veterinaria de Tandil-CIVETAN (CONICET/UNCPBA/CICPBA), Buenos Aires, Argentina., Camargos MF; Laboratório Federal de Defesa Agropecuária de Minas Gerais, Pedro Leopoldo, Brazil., Fonseca A; Laboratório Federal de Defesa Agropecuária de Minas Gerais, Pedro Leopoldo, Brazil., Barua S; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, 36849-5519, USA., Wang C; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, 36849-5519, USA., Giza A; Department of Omics Analyses, National Veterinary Research Institute, 24-100, Puławy, Poland., Kuźmak J; Department of Biochemistry, National Veterinary Research Institute, Puławy, 24-100, Poland.

Publikováno v: BMC veterinary research [BMC Vet Res] 2024 Aug 26; Vol. 20 (1), pp. 381. Date of Electronic Publication: 2024 Aug 26.

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Autor: Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Keenan K; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Cockerill M; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK.; These authors contributed equally: Mark Cockerill, Wendy A. Kellner., Kellner WA; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.; These authors contributed equally: Mark Cockerill, Wendy A. Kellner., Stowell A; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Sherk C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Wong K; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Pathuri S; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Briand J; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Steidel M; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Chapman P; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Groy A; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Wiseman AK; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., McHugh CF; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Campobasso N; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Graves AP; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Fairweather E; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Werner T; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Raoof A; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Butlin RJ; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Rueda L; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Horton JR; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fosbenner DT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Zhang C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Handler JL; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Muliaditan M; Drug Metabolism and Pharmacokinetics Modelling, GlaxoSmithKline, Stevenage, UK., Mebrahtu M; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Jaworski JP; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., McNulty DE; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Burt C; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Eberl HC; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Taylor AN; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Ho T; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Merrihew S; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Foley SW; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Rutkowska A; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Li M; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Romeril SP; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Goldberg K; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Zhang X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kershaw CS; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Bantscheff M; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Jurewicz AJ; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Minthorn E; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Grandi P; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Patel M; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Benowitz AB; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Mohammad HP; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Gilmartin AG; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Prinjha RK; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Carpenter C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Heerding D; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Baylin SB; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Jones PA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., Cheng X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., King BW; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Luengo JI; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Jordan AM; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Waddell I; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Kruger RG; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.

Publikováno v: Nature cancer [Nat Cancer] 2021 Oct; Vol. 2 (10), pp. 1002-1017. Date of Electronic Publication: 2021 Sep 27.

Neutralizing monoclonal antibodies for COVID-19 treatment and prevention.

Autor: Jaworski JP; National Scientific and Technical Research Council, Buenos Aires, Argentina; National Agricultural Technology Institute, Buenos Aires, Argentina. Electronic address: jaworski.juan@inta.gob.ar.

Publikováno v: Biomedical journal [Biomed J] 2021 Mar; Vol. 44 (1), pp. 7-17. Date of Electronic Publication: 2020 Nov 25.

Balance between Retroviral Latency and Transcription: Based on HIV Model.

Autor: Pluta A; Department of Biochemistry, National Veterinary Research Institute, 24-100 Puławy, Poland., Jaworski JP; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Instituto Nacional de Tecnología Agropecuaria (INTA), Instituto de Virología, Nicolás Repetto y De los Reseros (s/n), CP1686 Hurlingham, Buenos Aires, Argentina., Cortés-Rubio CN; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080 Mexico City, Mexico.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2020 Dec 29; Vol. 10 (1). Date of Electronic Publication: 2020 Dec 29.