Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jawid Nazir Ahmad"'
Autor:
Jawid Nazir Ahmad, Peter Sebo
Publikováno v:
mSphere, Vol 9, Iss 8 (2024)
ABSTRACT Bordetella pertussis infects the upper airways of humans and disarms host defense by the potent immuno-subversive activities of its pertussis (PT) and adenylate cyclase (CyaA) toxins. CyaA action near-instantly ablates the bactericidal activ
Externí odkaz:
https://doaj.org/article/7361cbb3d59b4394a34af6654b6982fb
Autor:
Jawid Nazir Ahmad, Peter Sebo
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging ins
Externí odkaz:
https://doaj.org/article/1ce48e426e6c4b49ab0fe321a867b6ea
Autor:
Jawid Nazir Ahmad, Jana Holubova, Oldrich Benada, Olga Kofronova, Ludek Stehlik, Martina Vasakova, Peter Sebo
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that bin
Externí odkaz:
https://doaj.org/article/0e10c91101794d2cb60859cedefcfb04
Autor:
Peter Sebo, Jawid Nazir Ahmad
Publikováno v:
Current Opinion in Infectious Diseases. 34:187-196
Purpose of review RTX toxin action often defines the outcome of bacterial infections. Here, we discuss the progress in understanding the impacts of RTX toxin activities on host immunity. Recent findings Bordetella pertussis CyaA activity paralyzes se
Autor:
Jana Holubova, Oldrich Benada, Martina Vasakova, Ludek Stehlik, Peter Sebo, Olga Kofronova, Jawid Nazir Ahmad
Publikováno v:
mBio, Vol 10, Iss 5, p e01743-19 (2019)
mBio
mBio, Vol 10, Iss 5 (2019)
mBio
mBio, Vol 10, Iss 5 (2019)
Macrophages are key sentinel cells of the immune system, and, as such, they are targeted by the toxins produced by the pertussis agent Bordetella pertussis. The adenylate cyclase toxin (CyaA) mediates immune evasion of B. pertussis by suspending the
Autor:
Radim Osicka, Pavel Mikulecký, Hana Šípová, Milan Kuchař, Petr Malý, V. Ševců, Jawid Nazir Ahmad, Jiří Homola
Publikováno v:
Sensors and Actuators B: Chemical. 174:306-311
Human interferon gamma (hIFNγ) is an important inflammatory cytokine, which is extensively expressed by immune system in response to various pathogens. In this work we present a biosensor for the direct detection of hIFNγ based on surface plasmon r
Autor:
Jiří Černý, Jiří Polínek, Petr Malý, Jan Malý, Radim Osicka, Lada Biedermannová, Jiří Vondrášek, Milan Kuchař, Hana Šípová, Pavel Mikulecký, Jingjing Li, Jiří Homola, Jawid Nazir Ahmad, Hana Petroková, Ondřej Staněk, Alena Semerádtová, Peter Sebo
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:774-789
Recombinant ligands derived from small protein scaffolds show promise as robust research and diagnostic reagents and next generation protein therapeutics. Here, we derived high-affinity binders of human interferon gamma (hIFNγ) from the three helix
Publikováno v:
Microbial Pathogenesis. 44:71-77
Ability of Mycobacterium smegmatis to assimilate nitrate was evaluated in its active and dormant phase. Nitrate (10 mM), nitrite (0.5 mM) and ammonia (10mM) allowed growth of M. smegmatis concomitant with their complete depletion from the culture in
Autor:
Milan Kuchař, Jiri Homola, V. Ševců, Pavel Mikulecký, Petr Malý, Peter Sebo, Jawid Nazir Ahmad, Hana Šípová
Publikováno v:
Procedia Engineering. :940-943
We present a novel surface plasmon resonance (SPR) biosensor for detection of human interferon gamma (hIFNγ), an important diagnostic marker for several infectious diseases. The biosensor employs engineered proteins derived from albumin binding doma