Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jawaharlal M. Patel"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124705 (2015)
Tolerance to allograft antigen is the major challenge and final goal of transplant medicine. Our previous study demonstrated that thioredoxin-1 (Trx) priming of donor lung significantly protected allogeneic lung graft. To determine whether Trx primin
Externí odkaz:
https://doaj.org/article/26ae0428ba5644879c0b41480a75556d
Publikováno v:
Protein & Peptide Letters. 23:169-175
Cell penetrating peptides can be used as therapeutic agents via modulation of selective cell functions. Nitric oxide (NO) generated by vascular endothelial NO synthase (eNOS) plays a critical role in the NO/ cyclic guanosine 5'-monophosphate (cGMP)-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9ba9518e1ec1719bdc80ae9fbd160a
https://doi.org/10.2174/0929866523666151211115151
https://doi.org/10.2174/0929866523666151211115151
Publikováno v:
Medical Research Archives. 5
We recently reported that priming donor lungs with thioredoxin-1 (Trx) prolongs allograft survival associated with inhibition of host spleen T cell response to donor antigen and cytokine modulation in a rat model of lung transplantation. The molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991cd00313d5a0826947d43c76a5a6dd
https://doi.org/10.18103/mra.v5i5.1232
https://doi.org/10.18103/mra.v5i5.1232
Autor:
Jawaharlal M. Patel, Yanfei Qi, Michael J. Katovich, Jane Yellowlees Douglas, J Mocco, Deepmala Agarwal, Erin Bruce, Altin Gjymishka, Anandharajan Rathinasabapathy, Chastity Bradford, Yagna P. R. Jarajapu, Patrick Kearns, Aqeela Afzal, Katya Rigatto, Mohan K. Raizada, Dipankar Gupta, Joo Yun Jun, Joseph Francis, Vinayak Shenoy, Kamal K. Mubarak, Rodrigo A. Fraga-Silva, William R. Kennedy, Maria B. Grant, Arturo J. Cardounel, Anderson J. Ferreira
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 187:648-657
Rationale: Studies have demonstrated that angiotensin-converting enzyme 2 (ACE2) plays a protective role against lung diseases, including pulmonary hypertension (PH). Recently, an antitrypanosomal drug, diminazene aceturate (DIZE), was shown to exert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68493d8f59a7cdd923357e3486837f2f
https://doi.org/10.1164/rccm.201205-0880oc
https://doi.org/10.1164/rccm.201205-0880oc
Autor:
Hanbo Hu, Hassan Alnuaimat, Defang Luo, Kamal K. Mubarak, Jeffrey K. Harrison, Jawaharlal M. Patel, Robin D. Carrie, Jianliang Zhang, Nadia L. Palma, Xiaoqiang Shen
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 303:L912-L922
Distal arterioles with limited smooth muscles help maintain the high blood flow and low pressure in the lung circulation. Chronic hypoxia induces lung distal vessel muscularization. However, the molecular events that trigger alveolar hypoxia-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1601327dbfabf600508c1941c30bd832
https://doi.org/10.1152/ajplung.00014.2012
https://doi.org/10.1152/ajplung.00014.2012
Publikováno v:
Peptides. 35:78-85
Pulmonary vascular endothelial nitric oxide (NO) synthase (eNOS)-derived NO is the major stimulant of cyclic guanosine 5′-monophosphate (cGMP) production and NO/cGMP-dependent vasorelaxation in the pulmonary circulation. We recently synthesized mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cecaa879b8c6682b3c4a968db981e64
https://doi.org/10.1016/j.peptides.2012.03.009
https://doi.org/10.1016/j.peptides.2012.03.009
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C1541-C1548
Activated arginase has been implicated in many diseases including cancer, immune cell dysfunction, infections, and vascular disease. Enhanced arginase activity has been reported in lungs of patients with pulmonary artery hypertension. We used hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77ac7f0d617131cc01e03cc25ffeb49
https://doi.org/10.1152/ajpcell.00068.2010
https://doi.org/10.1152/ajpcell.00068.2010
Autor:
Jan Cools, Franki Speleman, Iannis Aifantis, Martin S. Tallman, A R Payer, P. Van Vlierberghe, Hugo F. Fernandez, Concepcion Nicolas, Ross L. Levine, Cyrus V. Hedvat, Ari Melnick, Adolfo A. Ferrando, Jawaharlal M. Patel, Omar Abdel-Wahab, Peter Vandenberghe, Elisabeth Paietta, Milagros Balbín, Camille Lobry
Publikováno v:
Leukemia. 25:130-134
Loss of function mutations and deletions encompassing the plant homeodomain finger 6 (PHF6) gene are present in about 20% of T-cell acute lymphoblastic leukemias (ALLs). Here, we report the identification of recurrent mutations in PHF6 in 10/353 adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc45b6f1eb796dd2a57ae6a6fb3510c
https://doi.org/10.1038/leu.2010.247
https://doi.org/10.1038/leu.2010.247
Publikováno v:
Molecular and Cellular Biochemistry. 343:211-216
Arginase is an enzyme which converts arginine to ornithine and urea. Recently, arginase has been implicated in many physiological and pathological processes including vascular diseases. Inhibition of arginase activity by pharmacological inhibitors is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b320e2bfaa04faac908aa176e9f301
https://doi.org/10.1007/s11010-010-0515-5
https://doi.org/10.1007/s11010-010-0515-5
Autor:
Domenica Caramazza, Ming Mai, Lisa Pieri, Omar Abdel-Wahab, Christy Finke, Rebecca F. McClure, Jawaharlal M. Patel, Animesh Pardanani, D. G. Gilliland, A Tefferi, Outi Kilpivaara, Ross L. Levine, Terra L. Lasho, Paola Guglielmelli, Martha Wadleigh, Alessandro M. Vannucchi
Publikováno v:
Leukemia
In a multi-institutional collaborative project, 1473 patients with myeloproliferative neoplasms (MPN) were screened for isocitrate dehydrogenase 1 (IDH1)/IDH2 mutations: 594 essential thrombocythemia (ET), 421 polycythemia vera (PV), 312 primary myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846a5c145401cbf425cf3c46de301987
https://doi.org/10.1038/leu.2010.113
https://doi.org/10.1038/leu.2010.113