Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jawad S. Khalil"'
Autor:
Jawad S. Khalil, Robert Law, Zaher Raslan, Lih T. Cheah, Matthew S. Hindle, Ahmed A. Aburima, Mark T. Kearney, Khalid M. Naseem
Publikováno v:
Cells, Vol 13, Iss 13, p 1104 (2024)
Platelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase
Externí odkaz:
https://doaj.org/article/5fd59ece11a54f34802ee4458193261a
Publikováno v:
Platelets, Vol 31, Iss 7, Pp 913-924 (2020)
Rapid reorganization of the actin cytoskeleton in response to receptor-mediated signaling cascades allows platelets to transition from a discoid shape to a flat spread shape upon adhesion to damaged vessel walls. Coronins are conserved regulators of
Externí odkaz:
https://doaj.org/article/e5a9606336d34947b313ebb683a17cbe
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 356 (2020)
Remodeling of the actin cytoskeleton is one of the critical events that allows platelets to undergo morphological and functional changes in response to receptor-mediated signaling cascades. Coronins are a family of evolutionarily conserved proteins i
Externí odkaz:
https://doaj.org/article/c4ac36f58b8344f8a1dc56710d3f9e4d
Autor:
Martin Berger, David R. J. Riley, Julia Lutz, Jawad S. Khalil, Ahmed Aburima, Khalid M. Naseem, Francisco Rivero
Publikováno v:
Cells, Vol 8, Iss 2, p 149 (2019)
Typical Rho GTPases, such as Rac1, Cdc42, and RhoA, act as molecular switches regulating various aspects of platelet cytoskeleton reorganization. The loss of these enzymes results in reduced platelet functionality. Atypical Rho GTPases of the RhoBTB
Externí odkaz:
https://doaj.org/article/449064c5ca934e64a3ee839f9cf79267
Autor:
Jawad S Khalil, Paulo A. Saldanha, Connor M Blair, Jiayue Ling, Wei Ji, George S. Baillie, Khalid M Naseem, Leonid L Nikitenko, Francisco Rivero
The activity of myosin light chain phosphatase (MLCP) is fine-tuned by the phosphorylation status of the MLCP target subunit 1 (MYPT1), which is determined by the antagonistic effects of Rho kinase (ROCK) and cAMP/cGMP-dependent protein kinases (PKA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee74fe964fef6185883f51ab0f1c3e8a
https://doi.org/10.1101/2023.04.27.538407
https://doi.org/10.1101/2023.04.27.538407
Autor:
Francisco Rivero, Barbara-Ann Guinn, Pedro Beltran-Alvarez, David R. J. Riley, Neil T. Kemp, Antonia Barry, Jawad S. Khalil, Alistair James Marsden
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral
Publikováno v:
Platelets
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Rapid reorganization of the actin cytoskeleton in response to receptor-mediated signaling cascades allows platelets to transition from a discoid shape to a flat spread shape upon adhesion to damaged vessel walls. Coronins are conserved regulators of
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Platelets undergo profound shape changes upon adhesion to damaged blood vessel walls that are mediated by reorganisation of the actin cytoskeleton in response to receptor-mediated signalling cascades. The highly conserved 56 kDa multidomain cyclase a
Autor:
Julia Lutz, Martin Berger, Francisco Rivero, Jawad S. Khalil, Khalid M. Naseem, David R. J. Riley, Ahmed Aburima
Publikováno v:
Cells
Volume 8
Issue 2
Cells, Vol 8, Iss 2, p 149 (2019)
Volume 8
Issue 2
Cells, Vol 8, Iss 2, p 149 (2019)
Typical Rho GTPases, such as Rac1, Cdc42, and RhoA, act as molecular switches regulating various aspects of platelet cytoskeleton reorganization. The loss of these enzymes results in reduced platelet functionality. Atypical Rho GTPases of the RhoBTB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce2a384ecff898773bc64cbc4243698
https://eprints.whiterose.ac.uk/157322/1/cells-08-00149-v2.pdf
https://eprints.whiterose.ac.uk/157322/1/cells-08-00149-v2.pdf