Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Javiera Bravo Alegria"'
Autor:
Rodrigo Morales, Claudia Duran-Aniotz, Javiera Bravo-Alegria, Lisbell D. Estrada, Mohammad Shahnawaz, Ping-Ping Hu, Carlos Kramm, Diego Morales-Scheihing, Akihiko Urayama, Claudio Soto
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evalua
Externí odkaz:
https://doaj.org/article/0abd87e9c0524d7d9af4eb8a1dead7ab
Autor:
Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo-Alegria, Lei Guo, Lin Xu, Arif Harmanci, Vidya Gopalakrishnan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The RE1 Silencing Transcription Factor (REST) is a major regulator of neurogenesis and brain development. Medulloblastoma (MB) is a pediatric brain cancer characterized by a blockade of neuronal specification. REST gene expression is aberrantly eleva
Externí odkaz:
https://doaj.org/article/adbcf35e4afc4f71ab1fa836a5a1653c
Autor:
Nazaret Gamez, Javiera Bravo-Alegria, Yumeng Huang, Nelson Perez-Urrutia, Deepa Dongarwar, Claudio Soto, Rodrigo Morales
Publikováno v:
Cells, Vol 11, Iss 21, p 3442 (2022)
Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of Aβ seeds accelerates brain amyloidosis in both susceptible experimental animals and
Externí odkaz:
https://doaj.org/article/551a411c6f2c421d91dc34346da579e4
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies. Epigenetic pe
Externí odkaz:
https://doaj.org/article/09e9c2c69c5342869080a8ecec0677fc
Autor:
Hilda Ahnstedt, Meaghan Roy-O’Reilly, Monica S. Spychala, Alexis S. Mobley, Javiera Bravo-Alegria, Anjali Chauhan, Jaroslaw Aronowski, Sean P. Marrelli, Louise D. McCullough
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The prevalence of cardiovascular disease has increased among middle-aged women in the United States, yet has declined in middle-aged men. In experimental stroke, middle-aged females have larger strokes and greater inflammation than age-matched males
Externí odkaz:
https://doaj.org/article/d24e7fb6e256473dbd5288f5deab5aef
Autor:
Ariel Caviedes, Manuel Varas-Godoy, Carlos Lafourcade, Soledad Sandoval, Javiera Bravo-Alegria, Thilo Kaehne, Angela Massmann, Jorge P. Figueroa, Francisco Nualart, Ursula Wyneken
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Nitric oxide exerts important regulatory functions in various brain processes. Its synthesis in neurons has been most commonly ascribed to the neuronal nitric oxide synthase (nNOS) isoform. However, the endothelial isoform (eNOS), which is significan
Externí odkaz:
https://doaj.org/article/541c281478ae4b33b93c727932925059
Autor:
John d'Aigle, Monica S. Spychala, Liang Zhu, Anjali Chauhan, Joseph W Furr, Meaghan Roy-O'Reilly, Louise D. McCullough, Javiera Bravo Alegria, Anthony Patrizz, Frank W Blixt, Hilda Ahnstedt
Publikováno v:
Brain Behav Immun
INTRODUCTION: Stroke is a sexually dimorphic disease. While women account for more stroke deaths, recent data show that after adjusting for age and pre-stroke functional status, mortality is higher in men. Immune responses are key determinants of str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24aef39f6d556c61e062a4a405a10af
https://doi.org/10.1016/j.bbi.2020.02.001
https://doi.org/10.1016/j.bbi.2020.02.001
Autor:
Rodrigo, Morales, Javiera, Bravo-Alegria, Ines, Moreno-Gonzalez, Claudia, Duran-Aniotz, Nazaret, Gamez, George, Edwards Iii, Claudio, Soto
Publikováno v:
Molecular psychiatry. 26(10)
Previous reports showed that brain Aβ amyloidosis can be induced in animal models by exogenous administration of pre-formed aggregates. To date, only intra-peritoneal and intra-venous administrations are described as effective means to peripherally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c28a129bd3adb8d918d4887e5a805d3
https://pubmed.ncbi.nlm.nih.gov/36158163
https://pubmed.ncbi.nlm.nih.gov/36158163
Autor:
Diego Morales-Scheihing, Mohammad Shahnawaz, Lisbell D. Estrada, Javiera Bravo-Alegria, Rodrigo Morales, Claudia Duran-Aniotz, Claudio Soto, Akihiko Urayama, Ping-Ping Hu, Carlos Kramm
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d23579d9b2ecef838eaf49fc85cc673
https://pubmed.ncbi.nlm.nih.gov/33287898
https://pubmed.ncbi.nlm.nih.gov/33287898
Autor:
Andrea Becerra-Calixto, Claudio Soto, Charles E. Mays, Javiera Bravo-Alegria, Cesar Gonzalez, Enrique Armijo
Publikováno v:
Molecular Psychiatry. 23:2363-2374
The typical abnormalities observed in the brain of Alzheimer’s disease (AD) patients include synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein aggregates in the form of amyloid plaques and neurofibrillary tan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cd8a5bb1be7ca05b3a3e800809f144
https://doi.org/10.1038/s41380-018-0229-8
https://doi.org/10.1038/s41380-018-0229-8